Results 41 to 50 of about 76,126 (160)
Biochemistry Research International, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (A𝛽-)peptides in the brain causing progressive neuronal death.
Mallory Gough +2 more
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Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
Nature Communications, 2019 Amyloid beta (Aβ42) peptides form heterogeneous mixtures of aggregates, which are closely linked to Alzheimer’s disease.
Suman De +16 more
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Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Molecular Neurodegeneration, 2023 Background The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to technical challenges ...
Arun Upadhyay +6 more
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FEBS Open Bio, 2022 Accumulation of amyloid in breast cancer is a well‐known phenomenon, but only immunoglobulin light‐chain amyloidosis (AL) or transthyretin (TTR) amyloid had been detected in human breast tumor samples previously.
Astrid Zayas‐Santiago +5 more
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The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease
Frontiers in Neuroscience, 2019 Beta amyloid, Aβ 1–42, originally named as Amyloid A4 protein, is one of the most investigated peptides in neuroscience and has attracted substantial interest since its discovery as the main insoluble fibril-type protein in cerebrovascular amyloid ...
Heinz Hillen
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Probing oligomerization of amyloid beta peptide in silico
Molecular BioSystems, 2016 Abstract Aggregation of amyloid β (Aβ) peptide is implicated in fatal Alzheimer's disease, for which no cure is available. Understanding the mechanisms responsible for this aggregation is required in order for therapies to be developed.
L Dorosh, M Stepanova
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Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives [PDF]
Scientific Reports, 2017 AbstractThe self-assembly of two derivatives of KLVFF, a fragment Aβ(16–20) of the amyloid beta (Aβ) peptide, is investigated and recovery of viability of neuroblastoma cells exposed to Aβ (1–42) is observed at sub-stoichiometric peptide concentrations.
Castelletto, V. +13 more
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Thermodynamic selection of steric zipper patterns in the amyloid cross-beta spine. [PDF]
PLoS Computational Biology, 2009 At the core of amyloid fibrils is the cross-beta spine, a long tape of beta-sheets formed by the constituent proteins. Recent high-resolution x-ray studies show that the unit of this filamentous structure is a beta-sheet bilayer with side chains within ...
Jiyong Park +2 more
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PLoS ONE, 2014 Knowledge of the detailed mechanism by which proteins such as human αB- crystallin and human lysozyme inhibit amyloid beta (Aβ) peptide aggregation is crucial for designing treatment for Alzheimer's disease.
Payel Das +3 more
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Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Redox Biology, 2018 Oxidative stress is known to play an important role in the pathogenesis of a number of diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related neurodegenerative disease and the most common cause of dementia in the elderly.
Cheignon, Clémence +5 more
openaire +4 more sources