Results 41 to 50 of about 1,185,249 (285)

Electrochemical, Photoelectrochemical and Electrochemiluminescent Biosensors for the Detection of Betaamyloid Peptides and Their Aggregates

International Journal of Electrochemical Science, 2019
Beta-amyloid (Aβ) peptides are the specific biomarkers of Alzheimer's disease (AD). Many clinical studies have suggested that abnormal levels of Aβ peptides in blood, cerebrospinal fluid and brain tissue are closely related to the progression of AD ...
Ming La, Changdong Chen, Xichao Xia, Jihong Zhang, Binbin Zhou   +4 more
doaj   +1 more source

Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the receptor for advanced glycation end products [PDF]

, 2008
Amyloid beta (Aβ) has been postulated to be the principle initiator of the pathogenesis of Alzheimer’s disease (AD). Therefore, understanding the underlying mechanisms of Aβ induced neurotoxicity in the early stages of AD would be essential for finding ...
Ren, Yimin
core   +2 more sources

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice

Life, 2023
Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often considered to
Angelika Sabine Bader, Marius-Uwe Gnädig, Merle Fricke, Luca Büschgens, Lena Josefine Berger, Hans-Wolfgang Klafki, Thomas Meyer, Olaf Jahn, Sascha Weggen, Oliver Wirths   +9 more
doaj   +1 more source

Oligomers mediate the spatial transmission of Aβ peptide aggregation

Communications Chemistry
Alzheimer’s disease (AD) is marked by the abnormal aggregation of amyloid-beta peptides within the central nervous system. The formation of amyloid fibrils from amyloid-beta peptides is a hallmark of AD Here, we demonstrate that the aggregation of ...
Quentin Peter, Chris Taylor, Urszula Lapinska, Jiapeng Wei, Thomas C. T. Michaels, Paolo Arosio, Sara Linse, Tuomas P. J. Knowles   +7 more
doaj   +1 more source

Mulberry Fruit Cultivar ‘Chiang Mai’ Prevents Beta-Amyloid Toxicity in PC12 Neuronal Cells and in a Drosophila Model of Alzheimer’s Disease

Molecules, 2020
Alzheimer’s disease (AD) is the most common form of dementia, characterized by chronic neuron loss and cognitive problems. Aggregated amyloid beta (Aβ) peptides, a product of cleaved amyloid precursor protein (APP) by beta-secretase 1 (BACE-1), have been
Uthaiwan Suttisansanee, Somsri Charoenkiatkul, Butsara Jongruaysup, Somying Tabtimsri, Dalad Siriwan, Piya Temviriyanukul   +5 more
doaj   +1 more source

Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly

Frontiers in Molecular Neuroscience, 2023
Recent studies promote new interest in the intersectionality between autism spectrum disorder (ASD) and Alzheimer’s Disease. We have reported high levels of Amyloid-β Precursor Protein (APP) and secreted APP-alpha (sAPPa) and low levels of amyloid-beta ...
Deborah K. Sokol, Debomoy K. Lahiri, Debomoy K. Lahiri   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Investigation of low amyloid level toxicity effects on the function of hippocampal neurons

Open Life Sciences, 2015
Alzheimer disease (AD) is responsible for the majority of elderly dementia cases. There are multiple mouse models of AD, however, none of them completely recapitulate human pathology.
Popugaeva Elena, Pchitskaya Ekaterina, Zhang Hua, Vlasova Olga, Bezprozvanny Ilya   +4 more
doaj   +1 more source

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]

, 2008
Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley, Steven N. Johnson, Lin Xu, William Banks, Kelvin A. Yamada, Susan Farr   +5 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source