The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity
Neural Regeneration Research, 2013 Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to ...
Wang, Xu +7 more
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Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide [PDF]
, 2016 Many chronic degenerative diseases result from aggregation of misfolded polypeptides to form amyloids. Many amyloidogenic polypeptides are surfactants and their assembly can be catalysed by hydrophobic-hydrophilic interfaces (an air-water interface in ...
Hawkins, N +4 more
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Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent [PDF]
, 2007 The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has been studied in methanol. The peptide FFKLVFF is based on A beta(16-20) extended at the N terminus by two phenylalanine residues.
Castelletto, Valeria +2 more
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Analyzing Amyloid Beta Aggregates with a Combinatorial Fluorescent Molecular Sensor
Proceedings, 2017 The self-assembly of amyloid beta (Aβ) peptides into insoluble aggregates is thought to play a [...]
Joydev Hatai +2 more
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Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Scientific Reports, 2023 The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby
Irem Ulku +10 more
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Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. [PDF]
, 2017 Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration.
Adler-Abramovich, Lihi +10 more
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Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
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Amyloid-.BETA. peptide metabolism and Alzheimer's disease
Folia Pharmacologica Japonica, 2003 The deposition of amyloid-beta peptide (Abeta) causes the long-term pathological cascade of Alzheimer's disease (AD). Neprilysin is a rate-limiting peptidase, which participates in Abeta degradation in brain. As demonstrated by reverse genetics, the disruption of neprilysin gene causes an elevation in endogenous Abeta levels in the mouse brain in a ...
Nobuhisa, Iwata, Takaomi C, Saido
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d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors
Molecules, 2018 A causative factor for neurotoxicity associated with Alzheimer’s disease is the aggregation of the amyloid-β (Aβ) peptide into soluble oligomers.
Banafsheh Mehrazma +3 more
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The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
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