Results 21 to 30 of about 1,185,249 (285)

Insight into the structure of amyloid fibrils from the analysis of globular proteins. [PDF]

PLoS Computational Biology, 2006
The conversion from soluble states into cross-beta fibrillar aggregates is a property shared by many different proteins and peptides and was hence conjectured to be a generic feature of polypeptide chains.
Antonio Trovato, Fabrizio Chiti, Amos Maritan, Flavio Seno   +3 more
doaj   +1 more source

The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity

Neural Regeneration Research, 2013
Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to ...
Wang, Xu, Yang, Yi, Jia, Mingyue, Ma, Chi, Wang, Mingyu, Che, Lihe, Yang, Yu, Wu, Jiang   +7 more
openaire   +2 more sources

Analyzing Amyloid Beta Aggregates with a Combinatorial Fluorescent Molecular Sensor

Proceedings, 2017
The self-assembly of amyloid beta (Aβ) peptides into insoluble aggregates is thought to play a [...]
Joydev Hatai, David Margulies, Leila Motiei   +2 more
doaj   +1 more source

Astrocytic Redox Remodeling by Amyloid Beta Peptide [PDF]

Antioxidants & Redox Signaling, 2011
Astrocytes are critical for neuronal redox homeostasis providing them with cysteine needed for glutathione synthesis. In this study, we demonstrate that the astrocytic redox response signature provoked by amyloid beta (Aβ) is distinct from that of a general oxidant (tertiary-butylhydroperoxide [t-BuOOH]).
Garg, Sanjay K., Vitvitsky, Victor M., Albin, Roger L., Banerjee, Ruma   +3 more
openaire   +3 more sources

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

Scientific Reports, 2023
The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby
Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup   +10 more
doaj   +1 more source

Mitochondrial β-amyloid in Alzheimer's disease [PDF]

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Conway, SJ, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway   +20 more
core   +1 more source

d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors

Molecules, 2018
A causative factor for neurotoxicity associated with Alzheimer’s disease is the aggregation of the amyloid-β (Aβ) peptide into soluble oligomers.
Banafsheh Mehrazma, Stanley Opare, Anahit Petoyan, Arvi Rauk   +3 more
doaj   +1 more source

Passive Aβ Immunotherapy: Current Achievements and Future Perspectives

Molecules, 2018
Passive immunotherapy has emerged as a very promising approach for the treatment of Alzheimer’s disease and other neurodegenerative disorders, which are characterized by the misfolding and deposition of amyloid peptides. On the basis of the amyloid
Stephan Schilling, Jens-Ulrich Rahfeld, Inge Lues, Cynthia A. Lemere   +3 more
doaj   +1 more source

Structural Studies of Cystatin B Amyloid Fibre and Oligomer [PDF]

, 2013
Amyloid fibres are characteristic of over 25 degenerative human diseases including Alzheimer’s and Parkinson’s disease. Amyloid fibres are insoluble, highly stable, ordered cross-β sheet structures, which form as a result of conformational change and ...
Davis, Peter J.
core   +6 more sources

How γ-secretase hits a moving target

eLife, 2016
An improved understanding of the ways that amyloid-beta peptides are formed could help efforts to find a treatment for Alzheimer’s disease.
Charles R Sanders
doaj   +1 more source