Results 21 to 30 of about 109,107 (305)
The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity
Neural Regeneration Research, 2013 Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to ...
Wang, Xu +7 more
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Characterizing Heparin Tetrasaccharides Binding to Amyloid-Beta Peptide [PDF]
Frontiers in Molecular Biosciences, 2022 The aggregation of β-amyloid peptide (Aβ) is one potential cause for Alzheimer’s disease (AD). Heparin can either promote or inhibit Aβ aggregation. The sulfation pattern and chain size determine its binding affinity and its role. Using 2D-NMR analysis and molecular modelling, the binding motif of heparin oligoaccharides to Aβ was determined to be HexA-
Xiang Zhou +5 more
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Analyzing Amyloid Beta Aggregates with a Combinatorial Fluorescent Molecular Sensor
Proceedings, 2017 The self-assembly of amyloid beta (Aβ) peptides into insoluble aggregates is thought to play a [...]
Joydev Hatai +2 more
doaj +1 more source
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Scientific Reports, 2023 The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby
Irem Ulku +10 more
doaj +1 more source
Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-beta(38/40/42) in Frontotemporal Dementias and Primary Progressive Aphasias [PDF]
, 2010 Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25 ...
Hermann Esselmann +17 more
core +1 more source
d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors
Molecules, 2018 A causative factor for neurotoxicity associated with Alzheimer’s disease is the aggregation of the amyloid-β (Aβ) peptide into soluble oligomers.
Banafsheh Mehrazma +3 more
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Amyloid-.BETA. peptide metabolism and Alzheimer's disease
Folia Pharmacologica Japonica, 2003 The deposition of amyloid-beta peptide (Abeta) causes the long-term pathological cascade of Alzheimer's disease (AD). Neprilysin is a rate-limiting peptidase, which participates in Abeta degradation in brain. As demonstrated by reverse genetics, the disruption of neprilysin gene causes an elevation in endogenous Abeta levels in the mouse brain in a ...
IWATA, Nobuhisa, SAIDO, Takaomi C.
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Effects of Amyloid Beta Peptide on Neurovascular Cells
Central Asian Journal of Global Health, 2013 Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the neurons, and progressive deterioration of cognition and memory of affected individuals.
Sholpan Askarova +3 more
openaire +4 more sources
Passive Aβ Immunotherapy: Current Achievements and Future Perspectives
Molecules, 2018 Passive immunotherapy has emerged as a very promising approach for the treatment of Alzheimer’s disease and other neurodegenerative disorders, which are characterized by the misfolding and deposition of amyloid peptides. On the basis of the amyloid
Stephan Schilling +3 more
doaj +1 more source
How γ-secretase hits a moving target
eLife, 2016 An improved understanding of the ways that amyloid-beta peptides are formed could help efforts to find a treatment for Alzheimer’s disease.
Charles R Sanders
doaj +1 more source