Results 21 to 30 of about 76,126 (160)
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Scientific Reports, 2023 The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby
Irem Ulku +10 more
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Astrocytic Redox Remodeling by Amyloid Beta Peptide [PDF]
Antioxidants & Redox Signaling, 2011 Astrocytes are critical for neuronal redox homeostasis providing them with cysteine needed for glutathione synthesis. In this study, we demonstrate that the astrocytic redox response signature provoked by amyloid beta (Aβ) is distinct from that of a general oxidant (tertiary-butylhydroperoxide [t-BuOOH]).
Garg, Sanjay K. +3 more
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d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors
Molecules, 2018 A causative factor for neurotoxicity associated with Alzheimer’s disease is the aggregation of the amyloid-β (Aβ) peptide into soluble oligomers.
Banafsheh Mehrazma +3 more
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Passive Aβ Immunotherapy: Current Achievements and Future Perspectives
Molecules, 2018 Passive immunotherapy has emerged as a very promising approach for the treatment of Alzheimer’s disease and other neurodegenerative disorders, which are characterized by the misfolding and deposition of amyloid peptides. On the basis of the amyloid
Stephan Schilling +3 more
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How γ-secretase hits a moving target
eLife, 2016 An improved understanding of the ways that amyloid-beta peptides are formed could help efforts to find a treatment for Alzheimer’s disease.
Charles R Sanders
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G82S RAGE polymorphism is associated with Alzheimer’s disease
Frontiers in Bioscience-Elite, 2020 Receptor for advanced glycation end products (RAGE) has been implicated in the pathophysiology of Alzheimer’s disease (AD) due to its ability to interact with amyloid beta and to elicit an inflammatory response. sRAGE, one of the splice variants of RAGE,
Rani Cathrine Chellappa +1 more
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Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis
Translational Neurodegeneration, 2012 Alzheimer’s disease (AD) is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits of amyloid-beta (A-beta) peptides forming ...
Dong Suzhen +3 more
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Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study
Biomolecules, 2020 The amyloid plaques are a key hallmark of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Amyloidogenesis is a complex long-lasting multiphase process starting with the formation of nuclei of amyloid peptides: a process ...
Irini Doytchinova +4 more
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Frontiers in Aging Neuroscience, 2010 Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear.
Thomas A Bayer
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Autoxidation Enhances Anti-Amyloid Potential of Flavone Derivatives
Antioxidants, 2021 The increasing prevalence of amyloid-related disorders, such as Alzheimer’s or Parkinson’s disease, raises the need for effective anti-amyloid drugs. It has been shown on numerous occasions that flavones, a group of naturally occurring anti-oxidants, can
Andrius Sakalauskas +3 more
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