Results 161 to 170 of about 85,510 (321)

SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core

ChemBioChem, EarlyView.
The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic, Djenana Vejzovic, Altea Topciu, Kirill Kuhlmann, Raj Kumar, Maria Andrea Mroginski, Alejandra de Miguel, Pia Hofmann, Klaus Zangger, Markus Weingarth, Robert A. Cordfunke, Jan W. Drijfhout, Peter Nibbering, Michal Belicka, Karl Lohner, Nermina Malanovic   +15 more
wiley   +1 more source

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain [PDF]

, 2001
Harry F. Dovey, Varghese John, J. P. Anderson, L. Z. Chen, P. D. S. int Andrieu, Lanlan Fang, Stephen B. Freedman, B. Folmer, Erich Goldbach, Elzbieta J. Holsztynska, Kang Hu, Kelly Johnson‐Wood, S. L. Kennedy, Dora Kholodenko, Jeroen Knops, Lee H. Latimer, M. Lee, Zhengchang Liao, Ivan Lieberburg, Ruth Motter, Linda Mutter, J. Nietz, Kevin P. Quinn, K. L. Sacchi, Peter Seubert, George M. Shopp, Eugene D. Thorsett, Jay S. Tung, Jing Wu, Shao-Hua Yang, Chen Yin, Dale B. Schenk, Patrick C. May, L. Altstiel, Mark H. Bender, Leonard N. Boggs, T. C. Britton, James C. Clemens, Dan L. Czilli, Donna K. Dieckman-McGinty, J. J. Droste, Kimberly S. Fuson, Bruce D. Gitter, Paul A. Hyslop, Edward M. Johnstone, W‐Y. Li, Sharon Little, Thomas E. Mabry, F. DeWolfe Miller, B. Ni, Jeffrey S. Nissen, Warren J. Porter, B D Potts, Jon K. Reel, Diane Stephenson, Yuan Su, Lisa A. Shipley, Celia A. Whitesitt, Tao Yin, James E. Audia   +59 more
openalex   +1 more source

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

ChemBioChem, Accepted Article.
Nucleophosmin 1(NPM1) is an abundant human protein endowed with many functions whose dysregulation leads to various cancers and mutations are relevant in Acute Myeloid Leukemia (AML). In the wild type form, pentameric NPM1 resides mainly in the nucleolus even if it shuttles toward the cytosol exerting its chaperon function, conversely in AML‐mutated ...
Daniele Florio, Sara La Manna, Giada Raffaella Fiore, Valentina Roviello, Giuliano Castellano, Sossio Fabio Graziano, Anna Maria Malfitano, Daniela Marasco   +7 more
wiley   +1 more source

A Polyproline type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein‐protein Interaction Implicated in Breast Cancer

ChemBioChem, Accepted Article.
Given the essential role of protein‐protein interactions (PPIs) in cellular signalling pathways their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strategy, with various scaffolds reproducing recognition surfaces of α‐helical and β‐strand/sheet proteins.
James Luccarelli, Philip C. Simister, Andrew D. Hamilton, Stephan M. Feller, Sam Thompson   +4 more
wiley   +1 more source

Amyloid Beta Peptides and Th1 Cytokines Modulate Human Brain Vascular Smooth Muscle Tonic Contractile Capacity In Vitro: Relevance to Alzheimer's Disease? [PDF]

Pathophysiology, 2021
Yun JW, Washington C, McCormick J, Stevenson E, Alexander JS.   +4 more
europepmc   +1 more source

Three-Dimensional Amyloid-Beta PET Synthesis from Structural MRI with Conditional Generative Adversarial Networks [PDF]

arXiv
Motivation: Alzheimer's Disease hallmarks include amyloid-beta deposits and brain atrophy, detectable via PET and MRI scans, respectively. PET is expensive, invasive and exposes patients to ionizing radiation. MRI is cheaper, non-invasive, and free from ionizing radiation but limited to measuring brain atrophy.
arxiv  

Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application

Chronic Diseases and Translational Medicine, EarlyView.
Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash, Karthikeyan Elumalai   +1 more
wiley   +1 more source

Amyloid-Beta Peptides and Activated Astroglia Impairs Proliferation of Nerve Growth Factor Releasing Cells In Vitro: Implication for Encapsulated Cell Biodelivery-Mediated AD Therapy. [PDF]

Cells, 2021
Mitra S, Turchetto S, Van Os W, Wahlberg LU, Linderoth B, Behbahani H, Eriksdotter M.   +6 more
europepmc   +1 more source

New Aspects of Analyzing Amyloid Fibrils [PDF]

arXiv
This is a summary of mathematical tools we used in research of analyzing the structure of proteins with amyloid form \cite{xi2024Top}. We defined several geometry indicators on the discrete curve namely the hop distance, the discrete curvature and the discrete torsion.
arxiv  

Fisetin as a Blueprint for Senotherapeutic Agents – Elucidating Geroprotective and Senolytic Properties with Molecular Modeling

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The exceptional senotherapeutic activity of fisetin, combining both geroprotective and senolytic effects, was validated using computational chemistry tools, establishing it as a cornerstone template for the development of novel agents. Abstract Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a ...
Maciej Spiegel
wiley   +1 more source