Results 221 to 230 of about 120,218 (348)

Site-Specific Structural Changes in Unmodified and Pyroglutamylated Amyloid Beta Peptide by Isotope-Edited Ftir [PDF]

open access: bronze, 2015
Greg Goldblatt   +5 more
openalex   +1 more source

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

open access: yesMovement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

Glimepiride protects neurons against amyloid-beta-induced synapse damage [PDF]

open access: yes, 2016
Bate, C   +5 more
core   +1 more source

P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease

open access: green, 2017
Francisco Sáez-Orellana   +10 more
openalex   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova   +3 more
wiley   +1 more source

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