Results 241 to 250 of about 120,218 (348)

Probing Early α‐Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion‐Mobility Mass Spectrometry and Fluorescence Spectroscopy

PROTEOMICS, EarlyView.
ABSTRACT Misfolding and aggregation of α‐Synuclein (α‐Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α‐Syn segments, the NACore (68GAVVTGVTAVA78, WT‐PD1) and the preNAC region (47GVVHGVATVA56, WT‐PD2), using high‐resolution trapped ion ...
Agathe Depraz Depland, Stephanie Mikromanolis, Iuliia Stroganova, Anouk M. Rijs   +3 more
wiley   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Amyloid β-peptide induces dysfunctions in hippocampal area: an ICV injected rat model for Alzheimer's disease

, 2010
Botond Penke
openalex   +1 more source

P2–409: Neuroprotection by the synthetic enantiomers of the neurosteroids PREGS and DHEAS against beta‐amyloid 25–35 peptide–induced toxicity [PDF]

, 2013
Tangui Maurice, Yvette Akwa, Fadia El Bitar, Johann Meunier, Vanessa Villard, Marion Alméras, K. Krishnan, Douglas F. Covey   +7 more
openalex   +1 more source

The Molecular Basis of Growth Control in Guanine Crystals

Small, EarlyView.
Precise control over guanine crystal morphology is achieved through biologically inspired, facet‐selective interactions. Simple synthetic polymers tune growth from prisms to needles and plate‐like biogenic forms by modulating multivalency, polarity, and functional‐group identity.
Dolev Brenman‐Begin, Jonathan R. Church, Siddharth Sahoo, Zohar Eyal, Idan Biran, Nir Kampf, Yuval Barzilay, Anna Kossoy, Lothar Houben, Liel Sapir, Barak Hirshberg, Dvir Gur   +11 more
wiley   +1 more source

New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α‐Synuclein, Gold and Upconverting Nanoparticles

Small, EarlyView.
Gold and upconverting nanoparticles coated with alpha‐synuclein were exploited to produce a quasi‐monolayer hybrid film. The film was then characterized, and its behaviour as a primary optical nano‐thermometer was studied. The film was also used in a proof‐of‐concept study of image‐based optical nanothermometry exploiting a home‐built up‐conversion ...
Emil Milan, Roberto Tira, Chiara Cressoni, Federico Antonio Giacomazzi, Patrizia Canton, Michael Assfalg, Adolfo Speghini   +6 more
wiley   +1 more source

Beyond Pathology: α‐Synuclein Homeostasis and Three Principles to Guide Research

Movement Disorders Clinical Practice, EarlyView.
Alberto J. Espay, Andrew J. Lees
wiley   +1 more source

Charge Directed Selective Co‐Assembly of Ionic Complementary Peptide Binary Mixtures

Small, EarlyView.
Multi‐component peptide systems enable the development of multi‐functional and tunable materials, yet, controlling the co‐assembly of such complex systems remains challenging. This study demonstrates that rational design of peptide charge distribution, together with controlling parameters (pH, stoichiometry, and concentration), can guide selective co ...
Abdulwahhab Khedr, Mohamed A. N. Soliman, Alfred Corrigan, Tarsem Sahota, Rachel Armitage, Natalie Allcock, Jeyapriya T. Jegadeesan, Mahetab H. Amer, Reem Alazragi, Zeeshan Ahmad, Jacek K. Wychowaniec, Mohamed A. Elsawy   +11 more
wiley   +1 more source

Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane. [PDF]

Neurobiol Dis, 2018
Zhang L, Trushin S, Christensen TA, Tripathi U, Hong C, Geroux RE, Howell KG, Poduslo JF, Trushina E.   +8 more
europepmc   +1 more source

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

VIEW, EarlyView.
Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley   +1 more source