Results 241 to 250 of about 45,801 (303)
eFood, Volume 7, Issue 2, April 2026.This review article provides a comprehensive analysis of coffee pre‐brewing techniques, focusing on the methodology and key parameters involved in each coffee brewing process. It also summarizes how different brewing methods affect the coffee metabolome, antioxidant levels, aroma, and physicochemical features.
Enas A. El‐Hawary +5 more
wiley +1 more source
MedComm, Volume 7, Issue 4, April 2026.Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao +6 more
wiley +1 more source
Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 4, April 2026.The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song +4 more
wiley +1 more source
Analyzing Nicotine Action Against Amyloid Toxicity by NMR‐Pharmacometabolomics: An Exploratory Study
NMR in Biomedicine, Volume 39, Issue 4, April 2026.Combined metabolomic analysis of the intracellular and extracellular portions of SH‐SY5Y cells revealed that, in the presence of Aβ 1–42, nicotine primarily influences pathways related to neurotransmission, energy metabolism, as well as the biosynthesis and degradation of membrane phospholipids.
Enza Napolitano +5 more
wiley +1 more source
NMR in Biomedicine, Volume 39, Issue 4, April 2026.This study investigates the effect of cerebral and vascular (beta‐amyloid) Aβ on regional myeloarchitecture and lipid composition in a murine model of Alzheimer's disease (AD). The study highlights the feasibility of quantitative MRI and chemical exchange saturation transfer (CEST) imaging to identify multiple biophysical mechanisms involved in ...
Syed Salman Shahid +7 more
wiley +1 more source
ApoJ regulates endothelial lipase activity and stability
Protein Science, Volume 35, Issue 4, April 2026.Abstract Endothelial lipase (EL) is a key regulator of high‐density lipoprotein (HDL) metabolism. Many aspects of EL function remain incompletely understood due to challenges in purifying active EL. This study identifies apolipoprotein J (ApoJ) as a novel chaperone for EL, crucial for its solubility and activity.
Uriel L. Jean‐Baptiste +5 more
wiley +1 more source
In Vitro Characterization of Unmodified and Pyroglutamylated Alzheimer's Amyloid beta peptide
, 2014 Jason O. Matos
openalex +1 more source
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source