Results 301 to 310 of about 85,510 (321)

Efficient and accurate binding free energy calculation of Aβ9–40 protofilament propagation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
Abstract Self‐assembled aggregation of peptides and proteins into regular amyloid fibrils is associated with several neurodegenerative diseases. In case of Alzheimer's disease proteolytic cleavage products of the amyloid precursor protein form pathological amyloid‐beta fibrils in a nucleation and propagation phase.
Christina V. Frost, Nadine Schwierz, Martin Zacharias   +2 more
wiley   +1 more source

Investigating Local Sequence‐Structural Attributes of Amyloidogenic Light Chain Variable Domains

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Light chain amyloidosis is a medical condition characterized by the aggregation of misfolded antibody light chains into insoluble amyloid fibrils in the target organs, causing organ dysfunction, organ failure, and death. Despite extensive research to understand the factors contributing to amyloidogenesis, accurately predicting whether a given ...
Puneet Rawat, R. Prabakaran, Divya Sharma, Vasanth Mandala, Victor Greiff, Sandeep Kumar, M. Michael Gromiha   +6 more
wiley   +1 more source

Inflammasome-Mediated Neuroinflammation: A Key Driver in Alzheimer's Disease Pathogenesis. [PDF]

Biomolecules
McGroarty J, Salinas S, Evans H, Jimenez B, Tran V, Kadavakollu S, Vashist A, Atluri V.   +7 more
europepmc   +1 more source

Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis. [PDF]

Mol Neurodegener
Hardy J, Lewis P.
europepmc   +1 more source

Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition.

, 2008
Qingyou Li, Marcia N. Gordon, Marcus A. Etienne, Robert P. Hammer, Dave Morgan   +4 more
openalex  

The relationship between postoperative delirium and plasma amyloid beta oligomer. [PDF]

Sci Rep
Yang Y, Jung KJ, Kwak YT.
europepmc   +1 more source

Amyloid-ß Acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2 [PDF]

Alifragis, P, Austen, BM, Beesley, PW, Empson, RM, Russell, CL, Semerdjieva, S   +5 more
core  

The Effect of Polyethylene Terephthalate Nanoplastics on Amyloid-β Peptide Fibrillation. [PDF]

Molecules
Bashirova N, Schölzel F, Hornig D, Scheidt HA, Krueger M, Salvan G, Huster D, Matysik J, Alia A.   +8 more
europepmc   +1 more source

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

PROTEOMICS, EarlyView.
Paul Perco, Matthias Ley, Kinga Kęska‐Izworska, Dorota Wojenska, Enrico Bono, Samuel M. Walter, Lucas Fillinger, Klaus Kratochwill   +7 more
wiley   +1 more source

Exploring the Neuroprotective Properties of Celery (<i>Apium graveolens</i> Linn) Extract Against Amyloid-Beta Toxicity and Enzymes Associated with Alzheimer's Disease. [PDF]

Molecules
Mohamud Dirie L, Yurdakul T, Isik S, Tarbiat S.   +3 more
europepmc   +1 more source