Results 301 to 310 of about 120,218 (348)

Amyloid beta peptide directly inhibits PKC activation

Molecular and Cellular Neuroscience, 2004
A putative protein kinase C (PKC) pseudosubstrate domain in beta amyloid (Abeta) suggests a potential interaction between Abeta and PKC. In this study, we investigated whether and how Abeta interacts with PKC. Abeta peptides inhibited PKC phosphorylation in a dose-dependent manner in cell-free in vitro condition, suggesting a direct interaction between
Lee, W, Boo, JH, Jung, MW, Park, SD, Kim, YH, Kim, SU, Mook-Jung, I   +6 more
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Amyloid beta peptide immunotherapy in Alzheimer disease

Revue Neurologique, 2014
Recent advances in the understanding of Alzheimer's disease pathogenesis have led to the development of numerous compounds that might modify the disease process. Amyloid β peptide represents an important molecular target for intervention in Alzheimer's disease.
J, Delrieu, P J, Ousset, T, Voisin, B, Vellas   +3 more
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Amyloid Beta Peptide Folding in Reverse Micelles

Journal of the American Chemical Society, 2017
Previously published experimental studies have suggested that when the 40-residue amyloid beta peptide is encapsulated in a reverse micelle, it folds into a structure that may nucleate amyloid fibril formation (Yeung, P. S.-W.; Axelsen, P. H. J. Am. Chem. Soc. 2012, 134, 6061 ).
Gözde Eskici, Paul H Axelsen
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Electrochemistry of Alzheimer Disease Amyloid Beta Peptides

Current Medicinal Chemistry, 2018
Alzheimer’s disease (AD) is a widespread form of dementia that is estimated to affect 44.4 million people worldwide. AD pathology is closely related to the accumulation of amyloid beta (Aβ) peptides in fibrils and plagues, the small oligomeric intermediate species formed during the Aβ peptides aggregation presenting the highest neurotoxicity ...
Ana-Maria, Chiorcea-Paquim, Teodor Adrian, Enache, Ana Maria, Oliveira-Brett   +2 more
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Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis

Current Alzheimer Research, 2006
Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4 ...
Mark A, Lovell, William R, Markesbery
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Alzheimer's Disease and the Amyloid-β Peptide [PDF]

Journal of Alzheimer's Disease, 2010
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been puzzled by the weak to nonexistent correlation between the amount of neuritic plaque pathology in the human brain and the degree of clinical dementia.
Murphy M. Paul, LeVine, III Harry
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Natural human antibodies to amyloid beta peptide

Autoimmunity Reviews, 2008
Properties of human, natural anti-Abeta antibodies and commercially available intravenous immunoglobulin (IVIg) have been examined in light of the beneficial effects of passive immunotherapy with IVIg for patients with mild to moderate Alzheimer's disease (AD).
Paul, Szabo, Norman, Relkin, Marc E, Weksler   +2 more
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Diversity of amyloid beta peptide actions

Reviews in the Neurosciences
Abstract Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer’s disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight.
Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan   +2 more
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Protection against amyloid beta peptide toxicity by zinc

Brain Research, 1999
Zinc (Zn) is an essential element in normal development and biology, although it is toxic at high concentrations. Recent studies show that Zn at high concentrations accelerates aggregation of amyloid beta peptide (Abeta), the major component of senile plaques in Alzheimer's disease (AD).
M A, Lovell, C, Xie, W R, Markesbery
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Effect of ferric citrate on amyloid‐beta peptides behavior

Biopolymers, 2018
AbstractAmyloid beta (Aβ) aggregation and oxidative stress are two of the central events in Alzheimer's Disease (AD). Both these phenomena can be caused by the interaction of Aβ with metal ions. In the last years the interaction between ZnII, CuII, and Aβ was much studied, but between iron and Aβ it is still little known.
Galante D, Cavallo E, Perico A, D'Arrigo C   +3 more
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