Results 301 to 310 of about 118,464 (350)
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Neprilysin and Amyloid Beta Peptide Degradation
Current Alzheimer Research, 2008Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides. Structural studies show that neprilysin preferentially cleaves peptides on the amino side of hydrophobic amino acids.
Louis B, Hersh, David W, Rodgers
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Amyloid beta peptides and glutamatergic synaptic dysregulation
Experimental Neurology, 2008Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of glutamatergic synaptic ...
Kodeeswaran, Parameshwaran +2 more
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Interfacial Effects on the Conformation of Amyloid-Beta Peptide
Protein & Peptide Letters, 2009We examined the effects of air-water and water-sevoflurane interfaces on conformational properties of amyloid-beta peptide (ABP). Fractions were extracted from sub-interfacial (air-water) and supra-interfacial (water-sevoflurane) layers and compared with aqueous bulk layers using fluorescence properties of ABP provided by a single tyrosine.
Norbert W, Seidler, Joshua D, Eklund
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Amyloid beta peptide immunotherapy in Alzheimer disease
Revue Neurologique, 2014Recent advances in the understanding of Alzheimer's disease pathogenesis have led to the development of numerous compounds that might modify the disease process. Amyloid β peptide represents an important molecular target for intervention in Alzheimer's disease.
J, Delrieu +3 more
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Amyloid Beta Peptide Folding in Reverse Micelles
Journal of the American Chemical Society, 2017Previously published experimental studies have suggested that when the 40-residue amyloid beta peptide is encapsulated in a reverse micelle, it folds into a structure that may nucleate amyloid fibril formation (Yeung, P. S.-W.; Axelsen, P. H. J. Am. Chem. Soc. 2012, 134, 6061 ).
Gözde Eskici, Paul H Axelsen
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Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis
Current Alzheimer Research, 2006Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4 ...
Mark A, Lovell, William R, Markesbery
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In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides
2012The amyloid beta Ab(1-40) and Ab(1-42) peptides are the main components of the fibrillar plaques characteristically found in the brains affected by Alzheimer's disease. Fibril formation has been thoroughly studied in vitro using synthetic amyloid peptides and has been described to be a nucleation dependent polymerization process.
Núria, Benseny-Cases +2 more
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Electrochemistry of Alzheimer Disease Amyloid Beta Peptides
Current Medicinal Chemistry, 2018Alzheimer’s disease (AD) is a widespread form of dementia that is estimated to affect 44.4 million people worldwide. AD pathology is closely related to the accumulation of amyloid beta (Aβ) peptides in fibrils and plagues, the small oligomeric intermediate species formed during the Aβ peptides aggregation presenting the highest neurotoxicity ...
Ana-Maria, Chiorcea-Paquim +2 more
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Natural human antibodies to amyloid beta peptide
Autoimmunity Reviews, 2008Properties of human, natural anti-Abeta antibodies and commercially available intravenous immunoglobulin (IVIg) have been examined in light of the beneficial effects of passive immunotherapy with IVIg for patients with mild to moderate Alzheimer's disease (AD).
Paul, Szabo +2 more
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Diversity of amyloid beta peptide actions
Reviews in the NeurosciencesAbstract Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer’s disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight.
Sona Mardanyan +2 more
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