Results 201 to 210 of about 168,658 (234)

The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein

Biological Psychiatry, 1996
S.G. Younkin, X.H. Song, D. Scheuner, C. Eckman, C-M Prada, J. Jensen, L. Lannfelt, J. Hardy, R. Tanzi, G. Schellenberg, D. Selkoe, N. Suzuki   +11 more
openaire   +1 more source

X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.

Biochemistry, 1990
T. Hynes, M. Randal, L. Kennedy, C. Eigenbrot, A. Kossiakoff   +4 more
semanticscholar   +1 more source

Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

Ageing Research Reviews, 2023
Hayder M Al-Kuraishy, Gaber El-Saber Batiha, Salim Albukhaty   +2 more
exaly  

Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease.

Annals of the New York Academy of Sciences, 1993
The approximately 4 kD (39-43 amino acid) polypeptide (amyloid beta protein, A beta) deposited as amyloid in Alzheimer's disease (AD) is derived from a set of 695-770 residue precursor proteins collectively referred to as the amyloid beta-protein precursor (beta APP).
T E, Golde, X D, Cai, M, Shoji, S G, Younkin   +3 more
openaire   +1 more source

Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death.

Molecular and Chemical Neuropathology, 1996
B. Sopher, K. Fukuchi, Terrence J Kavanagh, C. E. Furlong, George M. Martin   +4 more
semanticscholar   +1 more source

CLN3 protein regulates lysosomal pH and alters intracellular processing of Alzheimer's amyloid-beta protein precursor and cathepsin D in human cells.

Molecular Genetics and Metabolism, 2000
A. Golabek, E. Kida, M. Walus, W. Kaczmarski, M. Michalewski, K. Wisniewski   +5 more
semanticscholar   +1 more source

The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix.

Brain Research, 1993
D. Schubert, C. Behl
semanticscholar   +1 more source

Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor.

Biochemical and Biophysical Research Communications - BBRC, 1989
T. Yamada, H. Sasaki, K. Dohura, I. Goto, Y. Sakaki   +4 more
semanticscholar   +1 more source

Effect of growth factors and cytokines on expression of amyloid beta protein precursor mRNAs in cultured neural cells.

Brain Research. Molecular Brain Research, 1993
Y. Ohyagi, T. Tabira
semanticscholar   +1 more source

THE AMYLOID BETA PROTEIN PRECURSOR GENE CONTAINS A COMPLEX TRANSCRIPTIONAL UNIT

Alzheimer Disease & Associated Disorders, 1988
J. W. TEENER, D. GOLDGABER, J. R. GILBERT, A. D. ROSES, D. C. GAJDUSEK   +4 more
openaire   +1 more source