Results 201 to 210 of about 4,375,511 (236)

In Situ Self‐Assembled Molecular Fortifying Agent for Enhanced Retention and Therapeutic Efficacy of Radiopharmaceuticals

Aggregate, Volume 7, Issue 10, October 2026.
A molecular‐fortifying agent strategy based on in situ self‐assembly is developed to prolong tumor retention of radioligands. After tumor‐targeting, FAP‐α cleavage triggers nanofiber formation, presenting azide anchors for bioorthogonal capture of pre‐accumulated radioligands.
Daojia Liu, Xiaoqin Luo, Xiaojuan Wang, Xing Liu, Fanglei Zhang, Pan Wang, Jibin Song, Junqiang Chen   +7 more
wiley   +1 more source

Pharmacodynamic and stage-dependent therapeutic efficacy of SFRP1 neutralization in a mouse model of Alzheimer's disease. [PDF]

Alzheimers Dement (N Y)
Miaja P, Martinez-Baños M, Martin-Bermejo MJ, Moreno I, Dominguez M, Bovolenta P.   +5 more
europepmc   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Higher Frontal Cortex Angiotensin Type 2 Receptor-Interacting Protein (ATIP) Levels Are Associated With a Lower Amyloid-Beta Burden in Postmortem Brains of Older Adults With Alzheimer's Disease. [PDF]

Aging Cell
Cosarderelioglu C, Kreimer S, Plaza-Rodriguez AI, Iglesias PA, Talbot CC, Siragy HM, Ubaida-Mohien C, Grodstein F, Ferrucci L, Bennett DA, Walston J, Abadir P.   +11 more
europepmc   +1 more source

Non‐invasive biomarkers in biliary atresia: A scoping review of fibrosis assessment, translational readiness and clinical implementation gaps

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Biomarkers are positioned by their highest developmental stage. Most biomarkers remain in exploratory phases, with serum MMP‐7 and elastography showing the greatest translational maturity. This highlights the primary challenge is the transition from biomarker discovery to clinical implementation.
Elizabeth Brits, Stephen Brown, Lezelle Botes, Michael Pienaar   +3 more
wiley   +1 more source

Pathological depositions in human disease: converging mechanisms in atherosclerosis, Alzheimer's disease, and related disorders. [PDF]

Mol Biomed
Ragolia L.
europepmc   +1 more source

Predicting Relevant Microglia‐Associated Cell–Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1

Glia, Volume 74, Issue 10, October 2026.
We used CellChat to infer altered cell–cell communication in Alzheimer's disease Microglia signal to each other via SPP1 in Alzheimer's disease. SPP1‐expressing microglia are present around amyloid‐β plaques. ABSTRACT Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease ...
Janssen M. Kotah, Marina Trombetta Lima, Esmée C. Dragt, Asimenia Voulgaroglou, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen   +7 more
wiley   +1 more source

In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2. [PDF]

Neuromolecular Med
Begum S, De Alvarez JA, Manzoni C, Arber C, Lewis PA.   +4 more
europepmc   +1 more source

PSEN1 Expression Identifies a Developmentally Distinct Favourable‐Prognosis State in SHH α Medulloblastoma

International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.
High PSEN1 expression identifies a favourable‐prognosis state in SHH α medulloblastoma and is associated with a reproducible transcriptional programme related to cellular homeostasis and development. Its broad expression during cerebellar development and across paediatric brain tumours suggests that its prognostic significance reflects the specific ...
Julia Vanini, Amanda Thomaz, Marina Müller Lupatini, André T. Brunetto, Caroline Brunetto de Farias, Mariane Jaeger, Rafael Roesler   +6 more
wiley   +1 more source

Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players. [PDF]

J Neurol Neurosurg Psychiatry
Graham N, Zimmerman K, Hain J, Rooney E, Lee Y, Del Giovane M, Parker T, Wilson M, Patel M, Veleva E, Swann O, Heslegrave AJ, Li LM, Zetterberg H, Friedland D, Sylvester R, Sharp D.   +16 more
europepmc   +1 more source