Results 231 to 240 of about 94,035 (378)

Overexpression of amyloid precursor protein A4 (beta-amyloid) immunoreactivity in genetically transformed cells: implications for a cellular model of Alzheimer amyloidosis. [PDF]

, 1989
Charles A. Marotta, W G Chou, Ronald E. Majocha, Russell Watkins, Carole LaBonne, Sayeeda B. Zain   +5 more
openalex   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

Traffic, Volume 24, Issue 1, Page 20-33, January 2023., 2023
Fission events at endo‐lyso interface could be favored in the presence of AP2S1, which is reminiscent of membrane fission during endocytosis. In contrast, lack of AP2S1 may inhibit this process, and alternatively facilitate endo‐lyso fusion and content exchange, leading to lysosomal degradation of APP.
Qi‐Xin Wen, Biao Luo, Xiao‐Yong Xie, Gui‐Feng Zhou, Jian Chen, Li Song, Yue Liu, Shi‐Qi Xie, Long Chen, Kun‐Yi Li, Xiao‐Jiao Xiang, Guo‐Jun Chen   +11 more
wiley   +1 more source

Early involvement of D-serine in β-amyloid-dependent pathophysiology. [PDF]

Cell Mol Life Sci
Billard JM, Ploux E, Largilliere S, Corvaisier S, Gorisse-Hussonnois L, Radzishevsky I, Wolosker H, Freret T.   +7 more
europepmc   +1 more source

The Amyloid Precursor Protein: More than Just Amyloid- Beta

, 2019
Stefan D. Jevtic, John Provias
openalex   +2 more sources

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. [PDF]

, 1993
Isabelle Daigle, C. Li
openalex   +1 more source

Beta-amyloid precursor protein cleavage by a membrane-bound protease. [PDF]

, 1992
Sangram S. Sisodia
openalex   +1 more source

Efficient and accurate binding free energy calculation of Aβ9–40 protofilament propagation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
Abstract Self‐assembled aggregation of peptides and proteins into regular amyloid fibrils is associated with several neurodegenerative diseases. In case of Alzheimer's disease proteolytic cleavage products of the amyloid precursor protein form pathological amyloid‐beta fibrils in a nucleation and propagation phase.
Christina V. Frost, Nadine Schwierz, Martin Zacharias   +2 more
wiley   +1 more source

Trelagliptin Ameliorates Memory Decline in Diabetic Rats through the AMPK/AKT/GSK-3β Pathway in the Cerebral Cortex. [PDF]

ACS Omega
Yao Y, Shu T, Guo X, Huang J, Chen Q, Liu X, Ouyang C, Yang X, Lei M.   +8 more
europepmc   +1 more source

Alzheimer’s Disease is Driven by Beta-Amyloid Generated in the Amyloid Precursor Protein-Independent Pathway and Retained Intraneuronally: Research and Therapeutic Strategies in a New AD Paradigm

, 2019
Vladimir Volloch, Sophia Rits‐Volloch
openalex   +1 more source