Results 251 to 260 of about 86,737 (312)

Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
David Schubert, Tsunao Saitoh, Tilman Oltersdorf   +2 more
exaly   +3 more sources

Genomic organization of the human-amyloid beta-protein precursor gene

Gene, 1990
Amyloid beta-protein (BP) deposited in Alzheimer brains is a cleavage product of a larger precursor (BPP). The BPP gene encodes three types of mRNA generated by alternative splicing, two of which contain the sequence encoding Kunitz-type serine-protease inhibitor (serpin).
S, Yoshikai, H, Sasaki, K, Doh-ura, H, Furuya, Y, Sakaki   +4 more
openaire   +2 more sources

Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor

Journal of Alzheimer's Disease, 2002
Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing of the amyloid β protein precursor (AβPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent ...
Xie, Ling, R N, Martins, M, Racchi, S, Craft, E, Helmerhorst   +4 more
openaire   +2 more sources

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

Essays in Biochemistry, 2002
The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases.
Janelle, Nunan, David H, Small
openaire   +2 more sources