Results 271 to 280 of about 86,737 (312)

Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid β‐Protein Precursor

Annals of the New York Academy of Sciences, 2002
Abstract: Cerebral amyloid β‐protein angiopathy (CAA) is a key pathological feature of patients with Alzheimer's disease and certain related disorders. Several mutations have been identified within the Aβ region of the Aβ protein precursor (AβPP) gene that appear to enhance the severity of CAA.
William E, Van Nostrand, Jerry P, Melchor, Galina, Romanov, Kelly, Zeigler, Judianne, Davis   +4 more
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Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity

Journal of Neurochemistry, 2003
AbstractThe amyloid β‐protein precursor (APP) is proteolytically cleaved to generate the amyloid β‐protein (Aβ), the principal constituent of senile plaques found in Alzheimer's disease (AD). In addition, Aβ in its oligomeric and fibrillar forms have been hypothesized to induce neuronal toxicity.
Daniel C, Lu, Salvador, Soriano, Dale E, Bredesen, Edward H, Koo   +3 more
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Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

Annual Review of Cell Biology, 1994
BIOCHEMICAL ANALYSES OF ALZHEIMER BRAIN LESIONS LEAD TO THE IDENTIFICATION OF A AND ITS PRECURSOR . . . . . . . . . . . . . . . . . . . 374 The Histopathology of Alzheimer's Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 374 Characterization of A and pp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Amyloid beta-protein precursor-rich platelet microparticles in thrombotic disease.

Thrombosis and haemostasis, 1995
We investigated the association of amyloid beta-protein precursor (APP) and platelet derived microparticles in 20 normal controls and 91 patients with various diseases causing a thrombotic tendency. Compared with the controls, the mean percentage of APP-positive microparticles was significantly greater in the patients with cerebral infarction (39.1 +/-
S, Nomura, Y, Komiyama, T, Miyake, Y, Miyazaki, H, Kido, M, Suzuki, H, Kagawa, M, Yanabu, H, Takahashi, S, Fukuhara   +9 more
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Alzheimer amyloid beta-protein precursor in sperm development.

The American journal of pathology, 1990
We prepared antisera to both the N and C termini of amyloid beta-protein precursor (APP). Both antisera labeled 110 to 140 kd proteins from rat testis by immunoblotting. Northern blot analysis using oligonucleotide probes complementary to respective APPs showed that APPs expressed in rat testis contained Kunitz-type protease inhibitor domains ...
M, Shoji, T, Kawarabayashi, Y, Harigaya, H, Yamaguchi, S, Hirai, T, Kamimura, T, Sugiyama   +6 more
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Thiophilic Interaction Chromatography (TIC) of Amyloid-β Protein Precursor

Journal of Alzheimer's Disease, 2007
Neuritic plaques, one of the diagnostic characteristics of an AD, contain extracellular deposits of amyloid-β (Aβ) derived from amyloid-β protein precursor (AβPP). The objective of this study was to extract AβPP out of HEK293 cells and to purify it. Two procedures were chosen for purification of AβPP: Thiophilic Interaction Chromatography (TIC) and ...
Mustapha, Bourhim, Tara, Johnson, Derek, Oyston, Thamarapu, Srikrishnan   +3 more
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Proteolytic processing of amyloid β protein precursor (APP) by thrombin

Biochemical and Biophysical Research Communications, 1992
Search for proteases responsible for an altered processing of APP which generates intermediates containing beta/A4 peptide is preceding to understand the formation of beta amyloid deposits characteristic of Alzheimer's disease, since many studies reveal that APP is ordinarily processed so as not to generate beta amyloid.
K, Igarashi, H, Murai, J, Asaka
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Cytoplasmic Tail Adaptors of Alzheimer's Amyloid-β Protein Precursor

Molecular Neurobiology, 2004
Alzheimer's disease is characterized pathologically by senile plaques in the brain. The major component of senile plaques is amyloid-beta (Abeta), which is cleaved from Alzheimer's Abeta protein precursor (AbetaPP). Recently, information regarding the cytoplasmic tail of AbetaPP has started to emerge, opening up various insights into the physiological ...
Masaoki, Kawasumi, Shuji, Matsuda, Masaaki, Matsuoka, Ikuo, Nishimoto   +3 more
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Magnesium Modulates Amyloid-β Protein Precursor Trafficking and Processing

Journal of Alzheimer's Disease, 2010
Alzheimer's disease (AD), the most common form of dementia, is characterized by the presence of excessive deposits of aggregated amyloid-β (Aβ), which is derived from the amyloid-β protein precursor (AβPP) following processing by β- and γ-secretase. Metal elements are implicated in the pathophysiology of AD.
Jia, Yu, Miao, Sun, Zheng, Chen, Jiangyang, Lu, Yi, Liu, Liang, Zhou, Xuemin, Xu, Dongsheng, Fan, Dehua, Chui   +8 more
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Detection of amyloid beta protein precursor immunoreactivity in normal and Alzheimer's disease cerebrospinal fluid

Life Sciences, 1990
The amyloid A4 (or beta protein), a 4.2 kD polypeptide, is a major component of amyloid deposits in the brains of patients with Alzheimer's Disease (AD). The self-aggregating amyloid A4 protein of AD is encoded as part of three larger proteins by the amyloid A4 precursor gene. The corresponding proteins have 695, 751 and 770 amino acid residues.
J K, Chong, B E, Miller, H A, Ghanbari
openaire   +2 more sources