Results 281 to 290 of about 86,737 (312)

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

Science, 1990
Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by extensive amyloid deposition in the small leptomeningeal arteries and cortical arterioles, which lead to an early death of those afflicted in their fifth or sixth decade ...
Van Broeckhoven, C., Haan, J., Bakker, E., Hardy, J.A., Vanhul, W., Wehrert, A., Vegter-Van der Vlis, M., Roos, R.A.C.   +7 more
openaire   +3 more sources

Evidence for lysosomal processing of amyloid ?-protein precursor in cultured cells

Neurochemical Research, 1989
Amyloid beta-protein precursor (ABPP) of Alzheimer's disease (AD) represents a family of proteins which includes the parent protein which generates a small (4 kD) fragment that self-assembles to form amyloid fibrils in AD. Thus, the normal and abnormal proteolysis of ABPP may be directly relevant to AD pathogenesis. We have examined the accumulation of
G M, Cole, T V, Huynh, T, Saitoh
openaire   +2 more sources

A novel mutation in the beta-protein coding region of the amyloid beta-protein precursor (APP) gene.

Human genetics, 1992
A novel mutation, a C to T transition at base pair 2124 in exon 17 of the amyloid beta-protein precursor (APP) gene, has been identified by direct sequencing of amplified DNA from two Alzheimer's disease (AD) patients. A simple oligonucleotide-hybridization procedure was developed to allow population studies of this DNA variation.
M, Balbín, M, Abrahamson, L, Gustafson, K, Nilsson, A, Brun, A, Grubb   +5 more
openaire   +1 more source

[Expression of amyloid beta protein and amyloid precursor protein after focal brain ischemia in human].

Zhonghua yi xue za zhi, 2007
To observe the expression of amyloid beta precursor protein and amyloid beta protein in neurons of hippocampal CA1 region after brain ischemia in human.Neuronal damage was examined by using HE staining, and expression of APP and Abeta(1-40) was determined by immunohistochemistry in the hippocampal CA1 region of the brain specimens of 43 patients who ...
Tian-zhu, Luan, Ji-ping, Qi, De-sheng, Wang, Yan-xin, Chen   +3 more
openaire   +1 more source

[Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor].

Zhonghua yi xue za zhi, 2000
To study the effect of GM1 ganglioside interfering the metabolism of amyloid beta-protein precursor (APP) on cells for exploring the relationship between GM1 and development of Alzheimer senile plaques and the other amyloidoses.GM1 influencing the metabolism of APP and the release of its metabolite secretory APP on human APP695 cDNA transfected cells ...
D, Zhang, Y, Ruan, K, Beyreuther
openaire   +1 more source

Widespread expression of amyloid beta-protein precursor gene in rat brain.

The American journal of pathology, 1989
The neuritic plaque is a characteristic finding in Alzheimer's disease. A major component of the plaque core is a 4.2 kd polypeptide, amyloid beta-protein (ABP), which is derived from the C-terminus of a larger precursor protein (ABPP). The authors have studied the transcription of ABPP mRNA in the adult rat brain by Northern analysis and in situ ...
S, Mita, E A, Schon, J, Herbert
openaire   +1 more source

The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein

Biological Psychiatry, 1996
S.G. Younkin, X.H. Song, D. Scheuner, C. Eckman, C-M Prada, J. Jensen, L. Lannfelt, J. Hardy, R. Tanzi, G. Schellenberg, D. Selkoe, N. Suzuki   +11 more
openaire   +1 more source

Structure and Expression of mRNA for the Mouse Homolog of Alzheimer Amyloid Beta Protein Precursor

1990
In the brain of patients with Alzheimer’s disease (AD), fibrillar amyloid is deposited as senile plaque core and cerebrovascular amyloidl(1,2). The beta protein or A4 protein is a major constituent of this amyloid and is now known to be the cleavage product of a larger precursor protein (BPP) which has features characteristic of glycosylated cell ...
Takeshi Yamada, Ryutaro Izumi, Hiroyuki Sasaki, Hirokazu Furuya, Ikuo Goto, Yoshiyuki Sasaki   +5 more
openaire   +1 more source

Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

Ageing Research Reviews, 2023
Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily   +2 more
exaly  

Production of amyloid beta protein precursor as a proteinase inhibitor by human astrocytic tumors.

Anticancer research, 2000
The production of amyloid beta protein precursor (APP), which is a potent inhibitor of matrix metalloproteinases and serine proteinases, in human astrocytic tumors (n = 17) and normal brain tissues (n = 3) was investigated. We found proteinase inhibitory activity at around 120 kD by trypsin reverse zymography in the culture media of explant cultures of
T, Nakagawa, M, Kabuto, T, Kubota, T, Kodera, K, Sato   +4 more
openaire   +1 more source