Results 261 to 270 of about 86,737 (312)

Amyloid β protein toxicity mediated by the formation of amyloid‐β protein precursor complexes

Annals of Neurology, 2003
AbstractThe amyloid‐β protein precursor, a type 1 transmembrane protein, gives rise to the amyloid β‐protein, a neurotoxic peptide postulated to be involved in the pathogenesis of Alzheimer's disease. Here, we show that soluble amyloid β protein accelerates amyloid precursor protein complex formation, a process that contributes to neuronal cell death ...
Daniel C, Lu, Gideon M, Shaked, Eliezer, Masliah, Dale E, Bredesen, Edward H, Koo   +4 more
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Localization of Alzheimer Amyloid Beta Protein Precursor and Its Relation to Senile Plaque Amyloid

Gerontology, 2009
The authors examined the ultrastructural localization of amyloid β protein precursor (APP) in normal human brains immu-nohistochemically using 3 kinds of APP antisera. The patterns of immunoreaction differed between the antisera used. Antise-rum 770, against APP_1–70, predominantly labeled the cytoplasm of neurons, whereas ...
H, Yamaguchi, T, Yamazaki, T, Kawarabayashi, X, Sun, Y, Sakai, S, Hirai   +5 more
openaire   +2 more sources

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Science, 1993
The 4-kilodalton amyloid βprotein (Aβ), which forms fibrillar deposits in Alzheimer's disease (AD), is derived from a large protein referred to as the amyloid β protein precursor (βAPP). Human neuroblastoma (M17) cells transfected with constructs expressing wild-type βAPP or a mutant, βAPP ΔNL , recently linked to ...
X D, Cai, T E, Golde, S G, Younkin
openaire   +2 more sources

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Biochemical and Biophysical Research Communications, 1987
The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a
T, Yamada, H, Sasaki, H, Furuya, T, Miyata, I, Goto, Y, Sakaki   +5 more
openaire   +2 more sources

Expression of Alzheimer Amyloid Beta-Protein Precursor Gene in Neuronal Cells

Gerontology, 2009
Five forms of Alzheimer amyloid β-protein precursors (APP or BPP) have been found. Among them, APP695 is predominantly found in neuronal cells and may be involved in some neuronal functions. In the present work, we investigated the relationship between the APP expression and the formation of neurites, a typical neuronal morphology, by measuring the ...
T, Yamada, E, Araki, R, Izumi, I, Goto, H, Sasaki, Y, Sakaki   +5 more
openaire   +2 more sources

Amyloid-beta precursor protein processing in neurodegeneration

Current Opinion in Neurobiology, 2004
The amyloid-beta precursor protein is proteolytically cleaved by secretases, resulting in a series of fragments, including the amyloid-beta peptide of Alzheimer's disease. The amyloid precursor protein, when membrane anchored, could operate as a receptor.
Bart De Strooper
exaly   +2 more sources

Expression of amyloid beta-protein precursor mRNAs in familial Alzheimerʼs disease

NeuroReport, 1991
The amyloid beta-protein precursor (APP) gene and its products are implicated in the pathogenesis of Alzheimer's disease. The differential expression of APP transcripts may contribute to this process. In the present study, the distribution of mRNAs encoding APP variants has been determined in the brain of three cases of familial Alzheimer's disease ...
P J, Harrison, A J, Barton, R C, Pearson
openaire   +2 more sources

Stimulated platelets release amyloid β-protein precursor

Biochemical and Biophysical Research Communications, 1990
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of ...
G M, Cole, D, Galasko, I P, Shapiro, T, Saitoh   +3 more
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Amyloid β-protein precursor is associated with extracellular matrix

Brain Research, 1990
The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.
F G, Klier, G, Cole, W, Stallcup, D, Schubert   +3 more
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Isoform Specific Amyloid-β Protein Precursor Metabolism

Journal of Alzheimer's Disease, 2007
Alzheimer's amyloid-β protein precursor (AβPP) can occur in different isoforms, among them AβPP751, which is the most abundant isoform in non-neuronal tissues, and AβPP695, often referred to as the neuronal isoform. However, few isoform-specific roles have been addressed.
Ana Gabriela, Henriques, Sandra Isabel, Vieira, Sandra, Rebelo, Sara C T S, Domingues, Edgar F, da Cruz e Silva, Odete A B, da Cruz e Silva   +5 more
openaire   +2 more sources