Results 231 to 240 of about 86,737 (312)

Double-edged role of N6-methyladenosine reader YTH structural domain family protein 2 in neurological disorders: Molecular mechanisms and translational prospects. [PDF]

World J Exp Med
Liu YM, Liu M, Yuan H, Li B.
europepmc   +1 more source

Genomic organization of the human amyloid beta-protein precursor gene

, 1991
openaire   +1 more source

Prediction of cognitive outcome and progression to dementia using ω6‐PUFA/ω3‐PUFA ratio

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The polyunsaturated fatty acids (PUFAs) omega‐6 (ω6) and omega‐3 (ω3) are linked to cognitive performance and Alzheimer's‐type dementia (DAT), but ω3‐PUFA supplementation offers limited benefits. We propose that the ω6‐PUFA/ω3‐PUFA ratio better explains cognitive decline and DAT risk.
Víctor Andrade, Luca Kleineidam, Holger Wagner‐Thelen, Tommaso Ballarini, Rafael Campos‐Martin, Pamela Martino‐Adami, Kumar Parijat Tripathi, Sophie Guyonnet, Bruno Vellas, Martin Scherer, Wolfgang Maier, Michael Pentzek, Matthias Schmid, Steffi Riedel‐Heller, Siegfried Weyerer, Horst Bickel, Birgitt Wiese, Sarah Egert, Michael Wagner, Alfredo Ramírez   +19 more
wiley   +1 more source

Pharmacology of nivegacetor (RG6289), a potent and selective gamma secretase modulator in clinical development for the treatment of Alzheimer's disease. [PDF]

Front Pharmacol
Lindemann L, Lambotte J, Rothe J, Messer J, Diener C, Pichereau S, Cantrill C, Mueggler T, Honer M, Beck J, Steinbrecher T, Tortelli R, Gerlach I, Ratni H, Rodriguez Sarmiento RM, Baumann K.   +15 more
europepmc   +1 more source

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source

The role of astrocytes as beta-amyloid degrading glial cells implications for alzheimer's disease [PDF]

Pihlaja, Rea
core  

Authorship and citation trends in dementia research: A path to equitable career development for scientists

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Women are increasingly entering the dementia research workforce, but they frequently fail to attain senior leadership positions in academia. Discrepancies in academic research outputs were investigated to guide equity‐focused policy recommendations.
Jayalakshmi Viswanathan, Diana Karamacoska, Lokendra S. Thakur, Mouna Sawan, Angela Gomez‐Arboledas, Ines Moreno‐Gonzalez, C. Elizabeth Shaaban, Sadaf A. Milani, Giedre Milinkeviciute, Samantha M. Loi, Anika Wuestefeld, Sindhuja T. Govindarajan, Audrey Low, Giovanna Carello‐Collar, Hom L. Shreshta, Sunnie Kenowsky, Claudia K. Suemoto, Michelle M. Mielke, Shana D. Stites   +18 more
wiley   +1 more source

Physiological Implications of Pancreatic Amyloid Polypeptide Aggregation and Its Inhibition by Melatonin. [PDF]

Int J Mol Sci
Yoo YM, Joo SS.
europepmc   +1 more source

Choroid plexus remodeling linked to impaired CSF‐mediated clearance and Alzheimer's disease progression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Impaired cerebrospinal fluid (CSF) ‐mediated clearance has been implicated in Alzheimer's disease (AD), but how choroid plexus (ChP) remodeling relates to these processes in vivo remains incompletely understood. METHODS In a large ADNI cohort, we integrated structural magnetic resonance imaging (MRI), amyloid/tau positron emission
Haolin Yin, Yuepeng Deng, ZiHao Lu, Yu Jiang, Chao Zuo, Jianyu Li, Linlin Guo, Binwu Ying, Giuseppe Battaglia, Xiaohe Tian, Qiyong Gong, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +11 more
wiley   +1 more source