Infantile exposure to lead and late-age cognitive decline: Relevance to AD [PDF]
, 2014 Background: Early-life lead (Pb) exposure induces overexpression of the amyloid beta precursor protein and its amyloid beta product in older rats and primates. We exposed rodents to Pb during different life span periods and examined cognitive function in
Alashwal +30 more
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Amyloid oligomer conformation in a group of natively folded proteins. [PDF]
PLoS ONE, 2008 Recent in vitro and in vivo studies suggest that destabilized proteins with defective folding induce aggregation and toxicity in protein-misfolding diseases.
Yuji Yoshiike +5 more
doaj +1 more source
Coupling enhanced sampling of the apo-receptor with template-based ligand conformers selection: Performance in pose prediction in the D3R-GC4 [PDF]
Journal of Computer-Aided Molecular Design 34, 149-162 (2020), 2020 We report the performance of our newly introduced Ensemble Docking with Enhanced sampling of pocket Shape (EDES) protocol coupled to a template-based algorithm to generate near-native ligand conformations in the 2019 iteration of the Grand Challenge organized by the D3R consortium.
arxiv +1 more source
Effects of the amyloid precursor protein Glu693→Gln ‘Dutch’ mutation on the production and stability of amyloid β-protein [PDF]
Biochemical Journal, 1999 Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D), is a cerebral amyloidosis characterized by prominent vascular deposits and fatal haemorrhages. The disorder is caused by a point mutation in codon 693 of the gene encoding the amyloid precursor protein (APP), resulting in a Glu → Gln amino acid substitution at position 22 of the ...
Watson, DJ, Selkoe, DJ, Teplow, DB
openaire +5 more sources
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. [PDF]
PLoS ONE, 2009 BACKGROUND: Transgenic mice expressing mutated amyloid precursor protein (APP) and presenilin (PS)-1 or -2 have been successfully used to model cerebral beta-amyloidosis, one of the characteristic hallmarks of Alzheimer's disease (AD) pathology. However,
Antje Willuweit +13 more
doaj +1 more source
Journal of Neuroinflammation, 2012 Background A growing body of evidence indicates that inflammation is one of the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown the occurrence of an early, pro-inflammatory reaction in the hippocampus of ...
Ferretti Maria +4 more
doaj +1 more source
Alzheimer's disease and HIV associated dementia related genes: I. location and function. [PDF]
, 2008 Alzheimer's disease (AD), the most common cause of dementia, has few clinical similarities to HIV-1-associated dementia (HAD). However, genes were identified related among these dementias.
Chiappelli, Francesco +5 more
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The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2. [PDF]
Proceedings of the National Academy of Sciences, 1991 The amyloid beta protein and the amyloid beta-protein precursor (APP) are major constituents of senile plaques and cerebrovascular deposits in patients with Alzheimer disease and Down syndrome. Most human tissues contain mRNA that encodes forms of APP that contain the Kunitz protease inhibitor (KPI+) domain.
Carl W. Cotman +6 more
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The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
core +1 more source