Results 11 to 20 of about 121,925 (285)

Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor.

Journal of Biological Chemistry, 1990
Protease nexin-2 (PN-2) is a protease inhibitor that is synthesized and secreted by a variety of extravascular cells including human fibroblasts. It forms sodium dodecyl sulfate-stable complexes with trypsin, the epidermal growth factor binding protein ...
W. V. Van Nostrand, S. Wagner, J. Farrow, D. Cunningham   +3 more
semanticscholar   +1 more source

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

Journal of Neuroinflammation, 2012
Background A growing body of evidence indicates that inflammation is one of the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown the occurrence of an early, pro-inflammatory reaction in the hippocampus of ...
Ferretti Maria, Allard Simon, Partridge Vanessa, Ducatenzeiler Adriana, Cuello A Claudio   +4 more
doaj   +1 more source

Neuregulin-1 Exerts Protective Effects Against Neurotoxicities Induced by C-Terminal Fragments of APP via ErbB4 Receptor

Journal of Pharmacological Sciences, 2012
Neuregulin-1 (NRG1) plays important roles in the development and plasticity of the brain, and it is also reported to have potent neuroprotective properties.
Junghwa Ryu, Ha-Nul Yu, Harim Cho, Hye-Sun Kim, Tai-Kyoung Baik, Soo-Joo Lee, Ran-Sook Woo   +6 more
doaj   +1 more source

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant   +8 more
doaj   +1 more source

The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation.

Journal of Biological Chemistry, 1997
The promoter of the amyloid beta-protein precursor (APP) gene directs high levels of cell type-specific transcription with 94 base pairs 5' to the main transcriptional start site.
A. Vostrov, W. Quitschke
semanticscholar   +1 more source

A guide to selecting high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research
The amyloid-beta precursor protein is a transmembrane protein expressed in many tissues and highly concentrated in the brain. The protein is of significant interest due to its involvement in the generation of amyloidogenic β-amyloid peptides, prone to ...
Carl Laflamme, Kathleen Southern, Donovan Worrall, Riham Ayoubi, Maryam Fotouhi   +4 more
doaj   +1 more source

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction.

PLoS ONE, 2009
BackgroundThe linkages between neuroinflammation and Alzheimer's disease (AD) pathogenesis are well established. What is not, however, is how specific immune pathways and proteins affect the disease.
Tomomi Kiyota, Masaru Yamamoto, Huangui Xiong, Mary P Lambert, William L Klein, Howard E Gendelman, Richard M Ransohoff, Tsuneya Ikezu   +7 more
doaj   +1 more source

HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

Nature Communications, 2017
HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function ...
Qingqing Chai, Vladimir Jovasevic, Viacheslav Malikov, Yosef Sabo, Scott Morham, Derek Walsh, Mojgan H. Naghavi   +6 more
doaj   +1 more source

The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease

Frontiers in Neurology, 2017
Alzheimer’s disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system.
Juanjuan Zhao, Dongxu Yue, Ya Zhou, Li Jia, Hairong Wang, Mengmeng Guo, Hualin Xu, Chao Chen, Jidong Zhang, Lin Xu   +9 more
doaj   +1 more source

Remodeling Alzheimer-amyloidosis models by seeding

Molecular Neurodegeneration, 2021
Alzheimer’s disease (AD) is among the most prevalent neurodegenerative diseases, with brain pathology defined by extracellular amyloid beta deposits and intracellular tau aggregates.
Brittany S. Ulm, David R. Borchelt, Brenda D. Moore   +2 more
doaj   +1 more source