Results 21 to 30 of about 86,737 (312)

Neuregulin-1 Exerts Protective Effects Against Neurotoxicities Induced by C-Terminal Fragments of APP via ErbB4 Receptor

Journal of Pharmacological Sciences, 2012
Neuregulin-1 (NRG1) plays important roles in the development and plasticity of the brain, and it is also reported to have potent neuroprotective properties.
Junghwa Ryu, Ha-Nul Yu, Harim Cho, Hye-Sun Kim, Tai-Kyoung Baik, Soo-Joo Lee, Ran-Sook Woo   +6 more
doaj   +1 more source

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant   +8 more
doaj   +1 more source

The role of amyloid precursor proteins : studies using neurons generated from wild-type and mutant embryonic stem cells [PDF]

, 2006
Alzheimer′s Disease (AD) is the most common neurodegenerative disorder in elderly people. It is becoming an ever larger problem due to prolonged life-expectancies in developed countries.
Schrenk, Katrin
core   +1 more source

A guide to selecting high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research
The amyloid-beta precursor protein is a transmembrane protein expressed in many tissues and highly concentrated in the brain. The protein is of significant interest due to its involvement in the generation of amyloidogenic β-amyloid peptides, prone to ...
Carl Laflamme, Kathleen Southern, Donovan Worrall, Riham Ayoubi, Maryam Fotouhi   +4 more
doaj   +1 more source

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction.

PLoS ONE, 2009
BackgroundThe linkages between neuroinflammation and Alzheimer's disease (AD) pathogenesis are well established. What is not, however, is how specific immune pathways and proteins affect the disease.
Tomomi Kiyota, Masaru Yamamoto, Huangui Xiong, Mary P Lambert, William L Klein, Howard E Gendelman, Richard M Ransohoff, Tsuneya Ikezu   +7 more
doaj   +1 more source

HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

Nature Communications, 2017
HIV infection results in elevated beta-amyloid (Aβ) levels in the brain, but the underlying mechanisms are unclear. Here, the authors show that amyloid precursor protein inhibits virion production and that HIV Gag, counteracting this antiviral function ...
Qingqing Chai, Vladimir Jovasevic, Viacheslav Malikov, Yosef Sabo, Scott Morham, Derek Walsh, Mojgan H. Naghavi   +6 more
doaj   +1 more source

The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer’s Disease

Frontiers in Neurology, 2017
Alzheimer’s disease (AD), with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system.
Juanjuan Zhao, Dongxu Yue, Ya Zhou, Li Jia, Hairong Wang, Mengmeng Guo, Hualin Xu, Chao Chen, Jidong Zhang, Lin Xu   +9 more
doaj   +1 more source

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH.

, 2002
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen, Liu, C, Austen, B, Chibuu Liu, Sidera, C, Christina Sidera   +5 more
core   +1 more source

APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]

, 1993
Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Sandbrink, R., Masters, C. L., Beyreuther, K., König, G., Mönning, U., Dichgans, Martin   +5 more
core   +1 more source

Tau protein, A beta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies [PDF]

, 2005
The intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis.
Cepek, L., Neumann, M., Ciesielczyk, Barbara, Cepek, Lukas, Neumann, Manuela, Trenkwalder, C., Kretzschmar, Hans A., Otto, M., Mollenhauer, B., Schulz-Schaeffer, W. J., Poser, Sigrid, Otto, Markus, Ciesielczyk, B., Steinacker, Petra, Steinacker, P., Wiltfang, J., Schulz-Schaeffer, Walter J., Poser, S., Bibl, Mirko, Mollenhauer, Brit, Trenkwalder, Claudia, Bibl, M., Wiltfang, Jens, Kretzschmar, H. A.   +23 more
core   +1 more source