Results 291 to 300 of about 122,310 (350)

Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor

Journal of Alzheimer's Disease, 2002
Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing of the amyloid β protein precursor (AβPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent ...
Xie, Ling, R N, Martins, M, Racchi, S, Craft, E, Helmerhorst   +4 more
openaire   +2 more sources

Genomic organization of the human-amyloid beta-protein precursor gene

Gene, 1990
Amyloid beta-protein (BP) deposited in Alzheimer brains is a cleavage product of a larger precursor (BPP). The BPP gene encodes three types of mRNA generated by alternative splicing, two of which contain the sequence encoding Kunitz-type serine-protease inhibitor (serpin).
S, Yoshikai, H, Sasaki, K, Doh-ura, H, Furuya, Y, Sakaki   +4 more
openaire   +2 more sources

Stimulated platelets release amyloid β-protein precursor

Biochemical and Biophysical Research Communications, 1990
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of ...
G M, Cole, D, Galasko, I P, Shapiro, T, Saitoh   +3 more
openaire   +2 more sources

Isoform Specific Amyloid-β Protein Precursor Metabolism

Journal of Alzheimer's Disease, 2007
Alzheimer's amyloid-β protein precursor (AβPP) can occur in different isoforms, among them AβPP751, which is the most abundant isoform in non-neuronal tissues, and AβPP695, often referred to as the neuronal isoform. However, few isoform-specific roles have been addressed.
Ana Gabriela, Henriques, Sandra Isabel, Vieira, Sandra, Rebelo, Sara C T S, Domingues, Edgar F, da Cruz e Silva, Odete A B, da Cruz e Silva   +5 more
openaire   +2 more sources

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Science, 1993
The 4-kilodalton amyloid βprotein (Aβ), which forms fibrillar deposits in Alzheimer's disease (AD), is derived from a large protein referred to as the amyloid β protein precursor (βAPP). Human neuroblastoma (M17) cells transfected with constructs expressing wild-type βAPP or a mutant, βAPP ΔNL , recently linked to ...
X D, Cai, T E, Golde, S G, Younkin
openaire   +2 more sources

Amyloid β protein toxicity mediated by the formation of amyloid‐β protein precursor complexes

Annals of Neurology, 2003
AbstractThe amyloid‐β protein precursor, a type 1 transmembrane protein, gives rise to the amyloid β‐protein, a neurotoxic peptide postulated to be involved in the pathogenesis of Alzheimer's disease. Here, we show that soluble amyloid β protein accelerates amyloid precursor protein complex formation, a process that contributes to neuronal cell death ...
Daniel C, Lu, Gideon M, Shaked, Eliezer, Masliah, Dale E, Bredesen, Edward H, Koo   +4 more
openaire   +2 more sources

Localization of Alzheimer Amyloid Beta Protein Precursor and Its Relation to Senile Plaque Amyloid

Gerontology, 1994
The authors examined the ultrastructural localization of amyloid beta protein precursor (APP) in normal human brains immunohistochemically using 3 kinds of APP antisera. The patterns of immunoreaction differed between the antisera used. Antiserum 770, against APP1-770, predominantly labeled the cytoplasm of neurons, whereas antiserum Z31, against the ...
H, Yamaguchi, T, Yamazaki, T, Kawarabayashi, X, Sun, Y, Sakai, S, Hirai   +5 more
openaire   +2 more sources

Expression of amyloid beta-protein precursor mRNAs in familial Alzheimerʼs disease

NeuroReport, 1991
The amyloid beta-protein precursor (APP) gene and its products are implicated in the pathogenesis of Alzheimer's disease. The differential expression of APP transcripts may contribute to this process. In the present study, the distribution of mRNAs encoding APP variants has been determined in the brain of three cases of familial Alzheimer's disease ...
P J, Harrison, A J, Barton, R C, Pearson
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Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

Essays in Biochemistry, 2002
The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases.
Janelle, Nunan, David H, Small
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Expression of Alzheimer Amyloid Beta-Protein Precursor Gene in Neuronal Cells

Gerontology, 1991
Five forms of Alzheimer amyloid beta-protein precursors (APP or BPP) have been found. Among them, APP695 is predominantly found in neuronal cells and may be involved in some neuronal functions. In the present work, we investigated the relationship between the APP expression and the formation of neurites, a typical neuronal morphology, by measuring the ...
T, Yamada, E, Araki, R, Izumi, I, Goto, H, Sasaki, Y, Sakaki   +5 more
openaire   +2 more sources