Results 291 to 300 of about 94,035 (378)

Macrophages and autophagy: partners in crime

The FEBS Journal, EarlyView.
Autophagy is a key regulator of macrophage function, influencing critical processes like polarization, cytokine secretion, and phagocytosis. Its impact on macrophage behavior varies across different tissues and disease contexts, where it can either promote protective responses or contribute to detrimental outcomes, depending on the physiological or ...
Alessandra Vitaliti, Alessio Reggio, Alessandro Palma   +2 more
wiley   +1 more source

The Peripheral Amyloid-β Nexus: Connecting Alzheimer's Disease with Atherosclerosis through Shared Pathophysiological Mechanisms. [PDF]

Neuromolecular Med
Khowdiary MM, Al-Kuraishy HM, Al-Gareeb AI, Albuhadily AK, Elhenawy AA, Rashwan EK, Alexiou A, Papadakis M, Fetoh MEA, Batiha GE.   +9 more
europepmc   +1 more source

A Bilingual Nanobiosensor for Cross‐Category Integrated Decoding of the Beta‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1–Aβ Oligomer Signaling Pathway

Tao Cheng, Peifen Lu, Yixi Dong, Jiabao Yu, Gang Wang, Jianwei Jiao, Peng Miao, Jin Jiao   +7 more
openalex   +1 more source

Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.

, 1995
Bernard Brugg, Yolande Lemaigre Dubreuil, G. Huber, E Wollman, Nicole Delhaye‐Bouchaud, Jean Mariani   +5 more
openalex   +1 more source

Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis

The FEBS Journal, EarlyView.
Enhancing endocannabinoid signaling by targeting FAAH effectively mitigates cognitive deficits, reduces amyloid pathology, and modulates neuroinflammatory responses in a preclinical model of Alzheimer's disease. This effect is potentially mediated by attenuating the Aβ‐induced overexpression of the Bace1 gene through CB1‐dependent hypermethylation of ...
Sergio Oddi, Lucia Scipioni, Antonio Totaro, Giacomo Giacovazzo, Francesca Ciaramellano, Daniel Tortolani, Alessandro Leuti, Rita Businaro, Federica Armeli, Andras Bilkei‐Gorzo, Roberto Coccurello, Andreas Zimmer, Mauro Maccarrone   +12 more
wiley   +1 more source

Targeting Amyloid Pathology in Early Alzheimer's: The Promise of Donanemab-Azbt. [PDF]

Pharmacy (Basel)
Khartabil N, Awaness A.
europepmc   +1 more source

Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate.

, 2000
Hisashi Koike, Zen Kouchi, Tadatoshi Kinouchi, Tatsuya Maeda, Hiroyuki Sorimachi, Takaomi C. Saido, Kei Maruyama, Akira Okuyama, Koichi Suzuki, Shoichi Ishiura   +9 more
openalex   +2 more sources

Hydromethylthionine sustains truncated tau‐dependent inflammation‐lowering effects in mouse brain

The FEBS Journal, EarlyView.
Hydromethylthionine (HMT) is an inhibitor of tau protein aggregation, but one that appears to be affected in subjects already receiving symptomatic treatments for dementia, such as memantine. We found that HMT decreased both tau aggregation and neuroinflammation in transgenic mice in a manner that was unaffected by memantine.
Renato X. Santos, Sophie H. Lee, Richard Lofthouse, Valeria Melis, Lianne Robinson, Michael Leith, Eline Dreesen, Paul Armstrong, Thomas Vorley, Elizabeth A. Goatman, Claire Hull, Gernot Riedel, Claude M. Wischik, Charles R. Harrington   +13 more
wiley   +1 more source

Natural aminosterols inhibit NMDA receptors with low nanomolar potency

The FEBS Journal, EarlyView.
Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani, Elisabetta Coppi, Silvia Errico, Federica Cherchi, Martina Gennari, Denise Barbut, Michele Vendruscolo, Michael Zasloff, Anna Maria Pugliese, Fabrizio Chiti   +9 more
wiley   +1 more source