Results 301 to 310 of about 94,035 (378)

The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer's disease animal model. [PDF]

Open Vet J
Titisari N, Ahmad H, Samsulrizal N, Fauzi A, Abdul Razak IS.   +4 more
europepmc   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

A de novo, mosaic and complex chromosome 21 rearrangement causes APP triplication and familial autosomal dominant early onset Alzheimer disease. [PDF]

Sci Rep
Ehn E, Eisfeldt J, Laffita-Mesa JM, Thonberg H, Schoumans J, Portaankorva AM, Viitanen M, Lindstrand A, Nennesmo I, Graff C.   +9 more
europepmc   +1 more source

Developmental deletion of amyloid precursor protein precludes transcriptional and proteomic responses to brain injury. [PDF]

Alzheimers Dement
Lacovich V, Čarna M, Novotný SJ, Wang S, Texlová K, Kovačovicova KL, Dragišić N, Havas D, Head BP, Geda YE, Limbäck-Stokin C, Stokin GB.   +11 more
europepmc   +1 more source

Assessing Co‐Localization of ITM2B With Alzheimer's Disease and Limbic‐Predominant Age‐Related TDP‐43 Encephalopathy Neuropathologic Changes

Neuropathology, EarlyView.
ABSTRACT Mutations in the Integral membrane protein 2B (ITM2B) gene are linked to the development of familial British and Danish dementias, two relatively early‐onset dementia disorders known also to be associated with Tau neurofibrillary tangles (NFTs).
Ryan K. Shahidehpour, Peter T. Nelson, Sukanya Srinivasan, Zhong Yu, Adam D. Bachstetter   +4 more
wiley   +1 more source

Rare case of wtTTR amyloidosis and MGUS in a patient with lung adenocarcinoma. [PDF]

BMJ Case Rep
Safdar A, Anwer F.
europepmc   +1 more source

Aggregating amyloid resources: A comprehensive review of databases on amyloid-like aggregation. [PDF]

Comput Struct Biotechnol J
Iglesias V, Chilimoniuk J, Pintado-Grima C, Bárcenas O, Ventura S, Burdukiewicz M.   +5 more
europepmc   +1 more source

Studying the Role of Myenteric Amyloidosis in Gastrointestinal Dysmotility and Enteric Neural Dysfunction Using APP/PS1 Mice—Is It an Adequate Animal Model?

Neurogastroenterology &Motility, EarlyView.
Amyloidosis in the central and enteric nervous system contributes to cognitive deficits and gastrointestinal dysmotility—the constipation in Alzheimer's disease (AD). APP/PS1 mice, a transgenic mouse model of amyloidosis, recapitulated the amyloidosis in the central nervous system; they were unsustainable in recapitulating the amyloidosis in the ...
Roxanne Fernandes, Marlene Masino, Emma Flood, Theresa A. Lansdell, Nikitha Srikrishna, Ryan Mui, Anne M. Dorrance, James J. Galligan, Hui Xu   +8 more
wiley   +1 more source

Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity. [PDF]

Mol Brain
Shaker MR, Salloum-Asfar S, Taha RZ, Javed I, Wolvetang EJ.   +4 more
europepmc   +1 more source