Results 301 to 310 of about 122,310 (350)

Amyloid beta-protein precursor-rich platelet microparticles in thrombotic disease.

Thrombosis and haemostasis, 1995
We investigated the association of amyloid beta-protein precursor (APP) and platelet derived microparticles in 20 normal controls and 91 patients with various diseases causing a thrombotic tendency. Compared with the controls, the mean percentage of APP-positive microparticles was significantly greater in the patients with cerebral infarction (39.1 +/-
S, Nomura, Y, Komiyama, T, Miyake, Y, Miyazaki, H, Kido, M, Suzuki, H, Kagawa, M, Yanabu, H, Takahashi, S, Fukuhara   +9 more
openaire   +2 more sources

Thiophilic Interaction Chromatography (TIC) of Amyloid-β Protein Precursor

Journal of Alzheimer's Disease, 2007
Neuritic plaques, one of the diagnostic characteristics of an AD, contain extracellular deposits of amyloid-β (Aβ) derived from amyloid-β protein precursor (AβPP). The objective of this study was to extract AβPP out of HEK293 cells and to purify it. Two procedures were chosen for purification of AβPP: Thiophilic Interaction Chromatography (TIC) and ...
Mustapha, Bourhim, Tara, Johnson, Derek, Oyston, Thamarapu, Srikrishnan   +3 more
openaire   +2 more sources

Magnesium Modulates Amyloid-β Protein Precursor Trafficking and Processing

Journal of Alzheimer's Disease, 2010
Alzheimer's disease (AD), the most common form of dementia, is characterized by the presence of excessive deposits of aggregated amyloid-β (Aβ), which is derived from the amyloid-β protein precursor (AβPP) following processing by β- and γ-secretase. Metal elements are implicated in the pathophysiology of AD.
Jia, Yu, Miao, Sun, Zheng, Chen, Jiangyang, Lu, Yi, Liu, Liang, Zhou, Xuemin, Xu, Dongsheng, Fan, Dehua, Chui   +8 more
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Cytoplasmic Tail Adaptors of Alzheimer's Amyloid-β Protein Precursor

Molecular Neurobiology, 2004
Alzheimer's disease is characterized pathologically by senile plaques in the brain. The major component of senile plaques is amyloid-beta (Abeta), which is cleaved from Alzheimer's Abeta protein precursor (AbetaPP). Recently, information regarding the cytoplasmic tail of AbetaPP has started to emerge, opening up various insights into the physiological ...
Masaoki, Kawasumi, Shuji, Matsuda, Masaaki, Matsuoka, Ikuo, Nishimoto   +3 more
openaire   +2 more sources

Amyloid β-protein precursor is associated with extracellular matrix

Brain Research, 1990
The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.
F G, Klier, G, Cole, W, Stallcup, D, Schubert   +3 more
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Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity

Journal of Neurochemistry, 2003
AbstractThe amyloid β‐protein precursor (APP) is proteolytically cleaved to generate the amyloid β‐protein (Aβ), the principal constituent of senile plaques found in Alzheimer's disease (AD). In addition, Aβ in its oligomeric and fibrillar forms have been hypothesized to induce neuronal toxicity.
Daniel C, Lu, Salvador, Soriano, Dale E, Bredesen, Edward H, Koo   +3 more
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[Expression of amyloid beta protein and amyloid precursor protein after focal brain ischemia in human].

Zhonghua yi xue za zhi, 2007
To observe the expression of amyloid beta precursor protein and amyloid beta protein in neurons of hippocampal CA1 region after brain ischemia in human.Neuronal damage was examined by using HE staining, and expression of APP and Abeta(1-40) was determined by immunohistochemistry in the hippocampal CA1 region of the brain specimens of 43 patients who ...
Tian-zhu, Luan, Ji-ping, Qi, De-sheng, Wang, Yan-xin, Chen   +3 more
openaire   +2 more sources

Pathogenic Effects of Cerebral Amyloid Angiopathy Mutations in the Amyloid β‐Protein Precursor

Annals of the New York Academy of Sciences, 2002
Abstract: Cerebral amyloid β‐protein angiopathy (CAA) is a key pathological feature of patients with Alzheimer's disease and certain related disorders. Several mutations have been identified within the Aβ region of the Aβ protein precursor (AβPP) gene that appear to enhance the severity of CAA.
William E, Van Nostrand, Jerry P, Melchor, Galina, Romanov, Kelly, Zeigler, Judianne, Davis   +4 more
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Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Biochemical and Biophysical Research Communications, 1987
The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a
T, Yamada, H, Sasaki, H, Furuya, T, Miyata, I, Goto, Y, Sakaki   +5 more
openaire   +2 more sources

Proteolytic processing of amyloid β protein precursor (APP) by thrombin

Biochemical and Biophysical Research Communications, 1992
Search for proteases responsible for an altered processing of APP which generates intermediates containing beta/A4 peptide is preceding to understand the formation of beta amyloid deposits characteristic of Alzheimer's disease, since many studies reveal that APP is ordinarily processed so as not to generate beta amyloid.
K, Igarashi, H, Murai, J, Asaka
openaire   +2 more sources