Results 61 to 70 of about 94,035 (378)
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Association of a BACE1 Gene Polymorphism with Parkinson’s Disease in a Norwegian Population
Parkinson's Disease, 2015 Background. Parkinson’s disease (PD) and Alzheimer’s disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the
Johannes Lange +7 more
doaj +1 more source
Substantial Doubt Remains about the Efficacy of Anti-Amyloid Antibodies [PDF]
arXiv, 2023 Alzheimer's disease (AD) is a prevalent, progressive, and ultimately fatal neurodegenerative disorder that is defined pathologically by the accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. There remains an unmet need for therapies that can halt or slow the course of AD. To address this need, the FDA has provided a mechanism,
arxiv
Distribution of amyloid β protein precursor in the Alzheimer’s disease brain [PDF]
Psychiatry and Clinical Neurosciences, 2000 AbstractIn order to clarify the distribution and pathological changes of the amyloid β protein precursor (βAPP), 10 Alzheimer’s disease (AD) brains and seven normal control brains were examined by immunocytochemistry and in situ hybridization histochemistry. All βAPP isoforms were distributed evenly in neuronal cell bodies and their axons and dendrites.
Mikio Shoji +6 more
openaire +3 more sources
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities [PDF]
, 2011 Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.
Brody, David L +3 more
core +2 more sources
Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine
Advanced Functional Materials, EarlyView.Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang +5 more
wiley +1 more source
Translational Neurodegeneration, 2012 Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs mainly the memory and cognitive function in elderly. Extracellular beta amyloid deposition and intracellular tau hyperphosphorylation are the two pathological events that are thought ...
Hong-Qi Yang, Zhi-Kun Sun, Sheng-Di Chen
doaj +1 more source
Neural Regeneration Research, 2023 Extracellular amyloid beta (Aβ) plaques are main pathological feature of Alzheimer’s disease. However, the specific type of neurons that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown.
Li-Fen Liu +7 more
doaj +1 more source
Advanced Materials, EarlyView.Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li +3 more
wiley +1 more source
Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method
The Scientific World Journal, 2014 Beta-amyloid precursor protein cleavage enzyme 1 (BACE1) and beta-amyloid precursor protein cleavage enzyme 2 (BACE2), members of aspartyl protease family, are close homologues and have high similarity in their protein crystal structures.
Hoda Mirsafian +3 more
doaj +1 more source