Results 71 to 80 of about 4,375,511 (236)
Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the receptor for advanced glycation end products [PDF]
, 2008 Amyloid beta (Aβ) has been postulated to be the principle initiator of the pathogenesis of Alzheimer’s disease (AD). Therefore, understanding the underlying mechanisms of Aβ induced neurotoxicity in the early stages of AD would be essential for finding ...
Ren, Yimin
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Use of Peptides for the Management of Alzheimer’s Disease: Diagnosis and Inhibition
Frontiers in Aging Neuroscience, 2018 Alzheimer’s disease (AD) is a form of dementia and the most common progressive neurodegenerative disease (ND). The targeting of amyloid-beta (Aβ) aggregation is one of the most widely used strategies to manage AD, and efforts are being made globally to ...
Mohammad H. Baig +3 more
doaj +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley +1 more source
Nature Communications, 2019 The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides ...
Yifan Wu +11 more
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Advanced NanoBiomed Research, EarlyView.This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim +4 more
wiley +1 more source
The role of amyloid precursor proteins : studies using neurons generated from wild-type and mutant embryonic stem cells [PDF]
, 2006 Alzheimer′s Disease (AD) is the most common neurodegenerative disorder in elderly people. It is becoming an ever larger problem due to prolonged life-expectancies in developed countries.
Schrenk, Katrin
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APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]
, 1993 Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Sandbrink, R. +5 more
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Pharmaceuticals, 2011 The review summarizes research into the highly relevant topics of cholinesterase and amyloid aggregation inhibitors connected to tacrine congeners, both of which are associated with neurogenerative diseases.
Maria Kozurkova +4 more
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Frontiers in Aging Neuroscience, 2012 The Morris swim navigation task (‘water maze’) has been a primary research tools to assess hippocampal delpendent spatial learning and memory is rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious
Heikki eTanila
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