Results 81 to 90 of about 168,658 (234)

APP SUMOylation prevents BACE1 cleavage of APP and increases BACE1 degradation to promote the nonamyloidogenic pathway

Molecular Medicine
Amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer’s disease (AD). APP undergoes different posttranslational modifications, but the role of SUMOylation modification of APP in the pathogenesis of AD is not known.
Yen-Chen Liu, Wei-Lun Hsu, Yun-Li Ma, Chung-Yao Yin, Kuang-Min Cheng, Eminy H. Y. Lee   +5 more
doaj   +1 more source

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

Neurobiology of Disease, 2011
There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and ...
Thimmappa S. Anekonda, Joseph F. Quinn, Christopher Harris, Kate Frahler, Teri L. Wadsworth, Randall L. Woltjer   +5 more
doaj   +1 more source

Golgi Fragmentation in Alzheimer’s Disease

Frontiers in Neuroscience, 2015
The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology.
Gunjan eJoshi, Michael eBekier, Yanzhuang eWang, Yanzhuang eWang   +3 more
doaj   +1 more source

New Insights in the Amyloid-Beta Interaction with Mitochondria

Journal of Aging Research, 2012
Biochemical and morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer’s disease (AD). Particularly, mitochondrial dysfunction is a hallmark of amyloid-beta-induced neuronal toxicity in Alzheimer’s disease ...
Carlos Spuch, Saida Ortolano, Carmen Navarro   +2 more
doaj   +1 more source

Beta-amyloid oligomers: recent developments

Biomolecular Concepts, 2011
Recent studies point to a critical role of soluble β-amyloid oligomers in the pathogenesis of one of the most common neurodegenerative diseases, Alzheimer's disease (AD).
Borutaite Vilmante, Morkuniene Ramune, Valincius Gintaras   +2 more
doaj   +1 more source

Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer’s disease

Frontiers in Physiology, 2012
Since the discovery of prion diseases, the concept that a transmissible pathogen could be a protein has emerged. As such, this transmissible protein agent can transfer its pathological mis-folded shape to the same but normally folded protein thus leading
Valerie eVingtdeux, Nicolas eSergeant, Luc eBuee   +2 more
doaj   +1 more source

Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations [PDF]

, 2006
Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress.
Czech, Christian, Eckert, Anne, Leutner, Silke, Müller, Walter E., Schindowski, Katharina, Touchet, Nathalie   +5 more
core  

Amyloid Beta (A4) Precursor Protein: A Potential Biomarker for Recurrent Nasopharyngeal Carcinoma

Cancer Management and Research, 2019
Xiao-Yu Li,1,* Hui-Ling Meng,2,* Kai-Guo Li,1 Xiao-Hui Yang,1 Xiao-Dong Zhu,1,3 Ling Li,1 Zhong-Guo Liang,1 Xin-Bin Pan,1 Fan-Yan Zeng,1 Song Qu1,3 1Department of Radiation Oncology, Affiliated Cancer Hospital of Guangxi Medical University, Cancer ...
Li XY, Meng HL, Li KG, Yang XH, Zhu XD, Li L, Liang ZG, Pan XB, Zeng FY, Qu S   +9 more
doaj  

An update on the toxicity of Aβ in Alzheimer’s disease

Neuropsychiatric Disease and Treatment, 2008
Jürgen Götz1, Lars M Ittner1, Nicole Schonrock1, Roberto Cappai21Alzheimer’s and Parkinson’s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia; 2Department of Pathology, The ...
Jürgen Götz, Lars M Ittner, Nicole Schonrock, Roberto Cappai   +3 more
doaj  

Differential effects of interleukin-1β and S100B on amyloid precursor protein in rat retinal neurons

Clinical Ophthalmology, 2009
Peter JB Anderson1, Helena R Watts1, Sheila Jen1, Stephen M Gentleman2, Juliet A Moncaster1, et al1Department of Cellular and Molecular Neuroscience and 2Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial ...
Peter JB Anderson, Helena R Watts, Sheila Jen, Stephen M Gentleman, Juliet A Moncaster, et al   +5 more
doaj