Results 91 to 100 of about 86,737 (312)

APP SUMOylation prevents BACE1 cleavage of APP and increases BACE1 degradation to promote the nonamyloidogenic pathway

Molecular Medicine
Amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer’s disease (AD). APP undergoes different posttranslational modifications, but the role of SUMOylation modification of APP in the pathogenesis of AD is not known.
Yen-Chen Liu, Wei-Lun Hsu, Yun-Li Ma, Chung-Yao Yin, Kuang-Min Cheng, Eminy H. Y. Lee   +5 more
doaj   +1 more source

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

Neurobiology of Disease, 2011
There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and ...
Thimmappa S. Anekonda, Joseph F. Quinn, Christopher Harris, Kate Frahler, Teri L. Wadsworth, Randall L. Woltjer   +5 more
doaj   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Golgi Fragmentation in Alzheimer’s Disease

Frontiers in Neuroscience, 2015
The Golgi apparatus is an essential cellular organelle for post-translational modifications, sorting, and trafficking of membrane and secretory proteins. Proper functionality of the Golgi requires the formation of its unique cisternal-stacking morphology.
Gunjan eJoshi, Michael eBekier, Yanzhuang eWang, Yanzhuang eWang   +3 more
doaj   +1 more source

In Silico Structure‐Guided Design of Peptide Candidates Targeting γ‐Secretase Subunit Assembly

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The γ‐secretase complex is a membrane‐embedded protease essential for intramembrane cleavage of substrates such as Notch receptors and the amyloid precursor protein (APP), processes central to cancer progression and Alzheimer's disease (AD) pathology.
Selcen Arı Yuka, Kübra Telli, Alper Yılmaz   +2 more
wiley   +1 more source

Plasma Aβ42 correlates positively with increased body fat in healthy individuals

, 2005
Obesity and overweight, well known risk factors for cardiovascular disease and type 2 diabetes, are now associated with Alzheimer's disease (AD). It remains to be determined if obesity and overweight contribute to the risk of developing AD through ...
Balakrishnana, K., Beilbye, J., Newton, Robert, Nolan, David, Martins, Ralph N., Newton, R., Mehta, P.D., Pankaj D. Mehta, David Nolan, Kelvin Balakrishnan, Galvão, Daniel A., Ralph N. Martins, Beilby, J., Gandy, Samuel E., Samuel E. Gandy, John Beilby, Giuseppe Verdile, Balakrishnan, Kelvin, Martins, R., Gandy, S., Verdile, G., Verdile, Giuseppe, Gandy, S.E., Galvao, D., Galvão, D.A., Nolan, D., Mehta, Pankaj D., Balakrishnan, K., Daniel A. Galvão, Beilby, John, Martins, R.N., Robert Newton, Mehta, P.   +32 more
core   +1 more source

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. [PDF]

, 2005
peer reviewedAlzheimer disease is associated with extracellular deposits of amyloid beta-peptides in the brain. Amyloid beta-peptides are generated by proteolytic processing of the beta-amyloid precursor protein by beta- and gamma-secretases.
Sandhoff, Konrad, Walter, Jochen, HENEKA, Michael, Prager, Kai, Tamboli, Irfan Y, Barth, Esther   +5 more
core   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease

, 2008
The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in
Griffin, W. Sue T., Braak, Heiko, Thal, Dietmar Rudolf   +2 more
core   +1 more source

New Insights in the Amyloid-Beta Interaction with Mitochondria

Journal of Aging Research, 2012
Biochemical and morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer’s disease (AD). Particularly, mitochondrial dysfunction is a hallmark of amyloid-beta-induced neuronal toxicity in Alzheimer’s disease ...
Carlos Spuch, Saida Ortolano, Carmen Navarro   +2 more
doaj   +1 more source