Results 91 to 100 of about 168,658 (234)

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

Proceedings of the National Academy of Sciences of the United States of America, 1989
D. Goldgaber, Herbert W. HARRISt, Timothy HLAt, Thomas MACIAGt, R. Donnelly, J. Jacobsen, M. Vitek, D. C. GAJDUSEKt   +7 more
semanticscholar   +1 more source

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

Proceedings of the National Academy of Sciences of the United States of America, 1992
Wilma Wasco, K. Bupp, M. Magendantz, J. Gusella, Rudolph E. Tanzi, Frank Solomon   +5 more
semanticscholar   +1 more source

Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation

Neural Regeneration Research, 2017
Sage Arbor
doaj   +1 more source

An Investigation of the Efficacy of Curcumin for Treatment of Alzheimer\u27s Disease [PDF]

, 2016
Curcumin is the primary curcuminoid found in the rhizome of the turmeric plant (Curcuma longa), responsible for the spice’s distinctive yellow color. Research conducted within the past two decades suggests that the compound may be an effective treatment ...
Patel, Parantap
core   +1 more source

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

EMBO Journal, 1987
M. Goedert
semanticscholar   +1 more source

Péptido beta amiloide, proteína Tau y enfermedad de Alzheimer

Revista Cubana de Investigaciones Biomédicas, 2002
Se realizó una actualización sobre la enfermedad de Alzheimer, que constituye la causa más frecuente de demencia. Se establecieron aspectos relacionados con los cromosomas 21 y 17.
Silvia Gra Menéndez, Noel Padrón Pérez, Juan de Jesús Llibre Rodríguez   +2 more
doaj  

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level

Frontiers in Pharmacology
Endogenous cardiotonic steroids (CTS), which are specific ligands of Na,K-ATPase, have been detected not only in blood plasma but also in cerebrospinal fluid and in the brain tissue.
Irina Yu. Petrushanko, Denis R. Lisitskii, Maria A. Strelkova, Anna P. Tolstova, Artemy P. Fedulov, Filipp A. Filonov, Vladimir A. Mitkevich, Alexander A. Makarov   +7 more
doaj   +1 more source

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.

Proceedings of the National Academy of Sciences of the United States of America, 1992
W. E. Nostrand, S. Wagner, W. Shankle, J. Farrow, Malcolm B. Dick, J. M. Rozemuller, M. A. Kuiper, E. C. Wolters, J. Zimmerman, C. Cotman   +9 more
semanticscholar   +1 more source

Activation of mTOR: a culprit of Alzheimer’s disease?

Neuropsychiatric Disease and Treatment, 2015
Zhiyou Cai,1 Guanghui Chen,1 Wenbo He,1 Ming Xiao,2 Liang-Jun Yan31Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, People’s Republic of China; 2Department of Anatomy, Nanjing ...
Cai Z, Chen G, He W, Xiao M, Yan LJ
doaj