Results 211 to 220 of about 249,317 (377)
Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis [PDF]
, 1995 Andréa C. LeBlanc
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Animal Models and Experimental Medicine, EarlyView.KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei +4 more
wiley +1 more source
Atrial amyloidosis: mechanisms and clinical manifestations
European Journal of Heart Failure, Volume 24, Issue 11, Page 2019-2028, November 2022., 2022 Atrial amyloidosis: pathophysiology and clinical manifestations. Atrial amyloidosis can manifest as part of a systemic disorder (as in amyloid light‐chain [AL] or transthyretin [ATTR] amyloidosis), or be isolated (in the form due to atrial natriuretic type [ANP] accumulation); this last form is often associated with permanent or persistent atrial ...
Giuseppe Vergaro +11 more
wiley +1 more source
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, EarlyView.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources
Neuroimaging Predictors of Cognitive Resilience against Alzheimer's Disease Pathology
Annals of Neurology, EarlyView.Objective Some individuals demonstrate greater cognitive resilience—the ability to maintain cognitive performance despite adverse brain‐related changes—through as yet unknown mechanisms. We examined whether cortical thickness in several brain regions confers resilience against cognitive decline in amyloid‐positive adults by moderating the effects of ...
McKenna E. Williams +7 more
wiley +1 more source
The relationship between postoperative delirium and plasma amyloid beta oligomer. [PDF]
Sci RepYang Y, Jung KJ, Kwak YT.
europepmc +1 more source
Cellular and molecular basis of beta-amyloid precursor protein metabolism [PDF]
, 1998 Huaxi Xu
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Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study
Annals of Neurology, EarlyView.Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos +8 more
wiley +1 more source
Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer's Disease. [PDF]
Int J Mol SciPokrzyk J +4 more
europepmc +1 more source