Results 281 to 290 of about 1,464,719 (336)

Amyloid Beta

Research Anthology on Diagnosing and Treating Neurocognitive Disorders, 2021
Alzheimer's disease (AD), exhibiting accumulation of amyloid beta (Aβ) peptide as a foremost protagonist, is one of the top five causes of deaths. It is a neurodegenerative disorder (ND) that causes a progressive decline in memory and cognitive abilities.
A. Anand, N. Sharma, M. Gulati, N. Khurana   +3 more
semanticscholar   +1 more source

Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers

Biochemical and Biophysical Research Communications, 2011
Aggregation of a peptide, beta-amyloid (Aβ), is a hallmark molecular process found in Alzheimer's disease (AD). During Aβ aggregation, oligomeric and fibrillar Aβ are formed, and these molecular self-assembly steps are implicated in generation of toxic effects in AD.
Joon Ho, Ahn, Yang, Hu, Michael, Hernandez, Jin Ryoun, Kim   +3 more
openaire   +2 more sources

Amyloid Beta

2019
Alzheimer's disease (AD), exhibiting accumulation of amyloid beta (Aβ) peptide as a foremost protagonist, is one of the top five causes of deaths. It is a neurodegenerative disorder (ND) that causes a progressive decline in memory and cognitive abilities. It is characterized by deposition of Aβ plaques and neurofibrillary tangles (NFTs) in the neurons,
Abhinav Anand, Neha Sharma, Monica Gulati, Navneet Khurana   +3 more
openaire   +1 more source

Amyloid beta.

The international journal of biochemistry & cell biology, 1999
Amyloid beta (A beta) is a 39-43 residue amyloidogenic peptide that is deposited into the extracellular amyloid plaques which characterize an Alzheimer's disease (AD) brain. A beta is derived from the amyloid precursor protein (APP) and undergoes a toxic conformational change (gain of toxic function).
R, Cappai, A R, White
openaire   +1 more source

Amyloid Beta: The Alternate Hypothesis

Current Alzheimer Research, 2006
Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and scientists are eager to decipher the underlying disease mechanism and, thereafter, target this therapeutically. Most investigators studying the underlying cause of AD have focused on amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the ...
Hyoung-gon, Lee, Xiongwei, Zhu, Akihiko, Nunomura, George, Perry, Mark A, Smith   +4 more
openaire   +2 more sources

Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neurotoxicity.

Brain : a journal of neurology, 2003
The accumulation of beta-amyloid (A beta) in neuritic plaques is thought to be causative for the progression of Alzheimer's disease (AD). Recently, both active immunization and passive administration of A beta antibodies dramatically attenuated amyloid plaque deposition, neuritic dystrophy, astrogliosis and behaviour deficits in transgenic animals.
Yansheng, Du, Xing, Wei, Richard, Dodel, Norbert, Sommer, Harald, Hampel, Feng, Gao, Zhizhong, Ma, Liming, Zhao, Wolfgang H, Oertel, Martin, Farlow   +9 more
openaire   +1 more source

Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor

Journal of Alzheimer's Disease, 2002
Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing of the amyloid β protein precursor (AβPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent ...
Xie, Ling, R N, Martins, M, Racchi, S, Craft, E, Helmerhorst   +4 more
openaire   +2 more sources