Results 291 to 300 of about 376,147 (348)

Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers

Biochemical and Biophysical Research Communications, 2011
Aggregation of a peptide, beta-amyloid (Aβ), is a hallmark molecular process found in Alzheimer's disease (AD). During Aβ aggregation, oligomeric and fibrillar Aβ are formed, and these molecular self-assembly steps are implicated in generation of toxic effects in AD.
Joon Ho, Ahn, Yang, Hu, Michael, Hernandez, Jin Ryoun, Kim   +3 more
openaire   +2 more sources

Clearance of Beta-Amyloid in the Brain

Current Medicinal Chemistry, 2014
Intravascular substances invade extracellular spaces in the brain via endothelial cells in the sites without bloodbrain barrier (BBB) and move not only in the cerebrospinal fluid (CSF) but also in the interstitial fluid (ISF) of brain parenchyma adjacent to non-BBB sites.
Masaki, Ueno, Yoichi, Chiba, Koichi, Matsumoto, Toshitaka, Nakagawa, Hiroshi, Miyanaka   +4 more
openaire   +2 more sources

Amyloid Beta: The Alternate Hypothesis

Current Alzheimer Research, 2006
Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and scientists are eager to decipher the underlying disease mechanism and, thereafter, target this therapeutically. Most investigators studying the underlying cause of AD have focused on amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the ...
Hyoung-gon, Lee, Xiongwei, Zhu, Akihiko, Nunomura, George, Perry, Mark A, Smith   +4 more
openaire   +2 more sources

Amyloid Beta

2019
Alzheimer's disease (AD), exhibiting accumulation of amyloid beta (Aβ) peptide as a foremost protagonist, is one of the top five causes of deaths. It is a neurodegenerative disorder (ND) that causes a progressive decline in memory and cognitive abilities. It is characterized by deposition of Aβ plaques and neurofibrillary tangles (NFTs) in the neurons,
Abhinav Anand, Neha Sharma, Monica Gulati, Navneet Khurana   +3 more
openaire   +1 more source

Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor

Journal of Alzheimer's Disease, 2002
Amyloid β (Aβ) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Aβ peptides can inhibit the effect of insulin on the metabolic processing of the amyloid β protein precursor (AβPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and memory, recent ...
Xie, Ling, R N, Martins, M, Racchi, S, Craft, E, Helmerhorst   +4 more
openaire   +2 more sources