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Neuro-degenerative diseases, 2007
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of ...
Verena H, Finder, Rudi, Glockshuber
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Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), a peptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of ...
Verena H, Finder, Rudi, Glockshuber
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Beta-amyloid immunisation in Alzheimer’s disease
Neurological Sciences, 2005Beta-amyloid immunisation in Alzheimer's ...
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Functional neurology, 1993
beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
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beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death.
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2023
Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
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Alzheimer's is one of the central topics in medical research and is gaining importance. The main cause of the disease is beta-amyloid, a protein that also occurs physiologically in the brain. However, a disturbed degradation leads to the formation of aggregates, which subsequently interfere with the transmission of stimuli and thus trigger the disease.
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Interleukin-1 beta dissociates beta-amyloid precursor protein and beta-amyloid peptide secretion.
FEBS letters, 1994A heightened production of interleukin 1 beta (IL-1 beta) has been reported in microglial-associated amyloid deposits in Alzheimer's disease (AD) brains. These plaques are composed predominantly of beta/A4 peptide derived from beta-amyloid precursor protein (beta APP).
J P, Vasilakos +6 more
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Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids
Chemical Reviews, 2021Dieter Willbold +2 more
exaly
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Nature Reviews Drug Discovery, 2022Eric Karran, Bart De Strooper
exaly