Results 41 to 50 of about 1,464,719 (336)
Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage [PDF]
, 2004 BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates.
Freeman, Melissa J +6 more
core +3 more sources
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Acta Neuropathologica, 2018 The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology.
Maitrayee Sardar Sinha +7 more
semanticscholar +1 more source
BMC Neuroscience, 2006 Background Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis.
Iwamoto Sean +4 more
doaj +1 more source
β-Amyloid Monomers Are Neuroprotective [PDF]
The Journal of Neuroscience, 2009 The 42-aa-long β-amyloid protein—Aβ 1-42 —is thought to play a central role in the pathogenesis of Alzheimer's disease (AD) (Walsh and Selkoe, 2007). Data from AD brain (Shankar et al., 2008), transgenic APP (amyloid precursor protein)-overexpressing mice (Lesné et al., 2006), and neuronal ...
ML Giuffrida +13 more
openaire +6 more sources
The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals
Annals of Neurology, 2018 Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in vivo neuroimaging.
R. Sperling +21 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2020 Background The aim of this longitudinal study was to assess with positron emission tomography (PET) the relationship between levels of inflammation and the loads of aggregated β-amyloid and tau at baseline and again after 2 years in prodromal Alzheimer's
Rola Ismail +10 more
semanticscholar +1 more source
The Contribution of S100B Suppression by Arundic Acid to the Inhibition of the Glio-Toxicity Induced by Beta-Amyloid in an Astrocytes Culture [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: It has been shown that glial activation has important role in the pathophysiology of Alzheimer’s disease. S100B is an astrocyte specific factor with deleterious effects on the neuronal and non-neuronal cells in the central nervous
Mahshid Hosseini +2 more
doaj
Neural Regeneration Research, 2022 Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj +1 more source
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Molecular Brain, 2020 Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles in the development of AD. Thus, considerable
Deepali Singh +5 more
doaj +1 more source