Results 41 to 50 of about 249,317 (377)

Accumulation of amyloid beta in human glioblastomas [PDF]

Clinical and Experimental Immunology, 2020
Summary Many cancer types are intrinsically associated with specific types of amyloidosis, in which amyloid is accumulated locally inside tumors or systemically. Usually, this condition relates to the hyperproduction of specific amylogenic proteins.
A Zayas-Santiago, A Díaz-García, R Nuñez-Rodríguez, M Inyushin   +3 more
openaire   +2 more sources

Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide [PDF]

, 2011
Understanding the influence of macromolecular crowding and nanoparticles on the formation of in-register $\beta$-sheets, the primary structural component of amyloid fibrils, is a first step towards describing \emph{in vivo} protein aggregation and ...
Allen M. P., Asakura S., Auer S., Batra J., Behe M., Bernard R. Brooks, Brooks B. R., Chan J. C. C., Cheung M. S., Chiti F., Colvin V. L., Colvin V. L., Cotter M. A., Cunha S., D. Thirumalai, del Álamao M., Dhar A., Dima R. I., Edward P. O’Brien, Elcock A. H., Fleer G. J., Flory P. J., Hall D., Hofrichter J., Jaroniec C. P., Jaroniec C. P., John. E. Straub, Lazaridis T., Lindner R. A., Linse S., Magno A., McGuffee S. R., Nelson R., Nelson R., Nguyen P. H., Petty S. A., Pierotti R. A., Rohrig U. F., Ross P. D., Sacchettini J. C., Schreiber G., Shaw M. R., Stagg L., Straub J. E., Tarus B., Tellam R. L., Tycko R., Walter H., Wu C., Zhou H. X., Zimmerman S. B.   +50 more
core   +1 more source

Amyloid Beta and MicroRNAs in Alzheimer’s Disease [PDF]

Frontiers in Neuroscience, 2019
Alzheimer's disease (AD) is a progressive mental illness characterized by memory loss and multiple cognitive impairments. In the last several decades, significant progress has been made in understanding basic biology, molecular mechanisms, and development of biomarkers and therapeutic drugs.
Nnana Amakiri, Aaron Kubosumi, James Tran, P. Hemachandra Reddy, P. Hemachandra Reddy, P. Hemachandra Reddy, P. Hemachandra Reddy, P. Hemachandra Reddy, P. Hemachandra Reddy, P. Hemachandra Reddy, P. Hemachandra Reddy   +10 more
openaire   +4 more sources

Immunogenic properties of amyloid beta oligomers [PDF]

Journal of Biomedical Science, 2013
The central molecule in the pathogenesis of Alzheimer's disease (AD) is believed to be a small-sized polypeptide - beta amyloid (Aβ) which has an ability to assemble spontaneously into oligomers. Various studies concerning therapeutic and prophylactic approaches for AD are based on the immunotherapy using antibodies against Aβ.
Indre Dalgediene, Aurelija Zvirbliene, Vilmante Borutaite, Gintaras Valincius, Rita Lasickiene, Ramune Morkuniene, Rima Budvytyte   +6 more
openaire   +3 more sources

Identification of Causal Relationship between Amyloid-beta Accumulation and Alzheimer's Disease Progression via Counterfactual Inference [PDF]

arXiv, 2023
Alzheimer's disease (AD) is a neurodegenerative disorder that is beginning with amyloidosis, followed by neuronal loss and deterioration in structure, function, and cognition. The accumulation of amyloid-beta in the brain, measured through 18F-florbetapir (AV45) positron emission tomography (PET) imaging, has been widely used for early diagnosis of AD.
arxiv  

Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric aggregates [PDF]

, 2008
The presence of oligomeric aggregates, which is often observed during the process of amyloid formation, has recently attracted much attention since it has been associated with neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.
AR Fersht, B Ma, B Urbanc, C Dirix, C Haass, Christopher M. Dobson, CM Dobson, DJ Selkoe, F Chiti, Filip Meersman, HD Nguyen, JD Harper, JR Banavar, LM Luheshi, M Cheon, M Cheon, M Fandrich, M Stefani, M Zhu, Michele Vendruscolo, MP Lambert, MS Turner, N Buchete, OS Makin, P Derreumaux, PH Nguyen, R Kayed, R Pellarin, R Pellarin, RA Kammerer, RD Hills, Ruth Nussinov, S Auer, S Auer, S Auer, SA Petty, Stefan Auer, T Jahn, TP Knowles, TPJ Knowles, TR Serio, TR Serio, TX Hoang, TX Hoang, W Hwang   +44 more
core   +5 more sources

Polarized secretion of beta-amyloid precursor proteinand amyloid beta-peptide in MDCK cells. [PDF]

Proceedings of the National Academy of Sciences, 1994
The beta-amyloid precursor protein (beta APP) is a widely expressed integral membrane protein that is proteolytically processed to yield several secreted derivatives, including soluble APP (APPs), the 4-kDa amyloid beta-peptide (A beta), and a related 3-kDa peptide (p3). To understand beta APP trafficking and processing, we analyzed the sorting of beta
Dennis J. Selkoe, Christian Haass, David B. Teplow, Edward H. Koo   +3 more
openaire   +3 more sources

Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity

Molecular Brain, 2020
Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles in the development of AD. Thus, considerable
Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth, Shiv Kumar Sharma   +5 more
doaj   +1 more source

Analyzing the Spatiotemporal Interaction and Propagation of ATN Biomarkers in Alzheimer's Disease using Longitudinal Neuroimaging Data [PDF]

arXiv, 2021
Three major biomarkers: beta-amyloid (A), pathologic tau (T), and neurodegeneration (N), are recognized as valid proxies for neuropathologic changes of Alzheimer's disease. While there are extensive studies on cerebrospinal fluids biomarkers (amyloid, tau), the spatial propagation pattern across brain is missing and their interactive mechanisms with ...
arxiv  

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?

Neural Regeneration Research, 2022
Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj   +1 more source