Results 141 to 150 of about 82,488 (290)

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein

Heliyon, 2018
Amyloid β, a key molecule in the pathogenesis of Alzheimer's disease (AD), is produced from amyloid precursor protein (APP) by the cleavage of secretases. APP is SUMOylated near the cleavage site of β-secretase.
Takuma Maruyama, Yoichiro Abe, Takako Niikura   +2 more
doaj  

A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene.

, 1994
JoAnn Trejo, Tania Massamiri, T Deng, Nazneen N. Dewji, Richard M. Bayney, Joan Heller Brown   +5 more
openalex   +1 more source

Phorbol Esters Affect Multiple Steps in β-Amyloid Precursor Protein Trafficking and Amyloid β-Protein Production [PDF]

, 1997
Edward H. Koo, Paul Greengard
openalex   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

A synapse perspective on the function of the amyloid precursor protein. [PDF]

Sci Prog
Kruse P, Eichler A, Klukas L, Lenz M.
europepmc   +1 more source

Processing of Alzheimer Aβ-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer Disease

, 1994
Sam Gandy, Paul Greengard
openalex   +1 more source

Oxidative Stress Increases Production of β-Amyloid Precursor Protein and β-Amyloid (Aβ) in Mammalian Lenses, and Aβ Has Toxic Effects on Lens Epithelial Cells [PDF]

, 1996
Peter H. Frederikse, Donita Garland, J. Samuel Zigler, Joram Piatigorsky   +3 more
openalex   +1 more source

Systemic Transthyretin Amyloidosis Incidentally Diagnosed With Prostate Biopsy: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction The diagnosis of systemic transthyretin amyloidosis based on prostate biopsy is very rare, and we report this case with a literature review. Case Presentation A 73‐year‐old male patient was referred to our department due to an increased serum prostate‐specific antigen level at 10.4 ng/mL while receiving benign prostatic ...
Michihide Nakamura, Shinnosuke Kuroda, Takashi Kawahara, Erika Muraoka, Genya Iwamoto, Kota Shimokihara, Takeaki Noguchi, Masanobu Yamazaki, Akihito Hashizume, Daiji Takamoto, Rie Horii, Satoshi Fujii, Miki Tanoshima, Junichi Teranishi, Hiroji Uemura   +14 more
wiley   +1 more source

Expression and function of β-site amyloid precursor protein-cleaving enzyme 2 in vascular endothelium. [PDF]

Am J Physiol Heart Circ Physiol
d'Uscio LV, Kovalenko T, He T, Christensen TA, Salisbury JL, Katusic ZS.   +5 more
europepmc   +1 more source