Results 171 to 180 of about 343,599 (390)

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

Movement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

New capacities of the diagnosis and monitoring of the course of AL-amyloidosis

Терапевтический архив, 2010
Aim: to define the clinical value of various concentrations of immunoglobulin light chains (ILCs) in patients with AL amyloidosis. Subjects and methods.
V V Rameyev, L V Kozlovskaya, I N Kogarko, B S Kogarko   +3 more
doaj  

Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease

, 2016
Álvaro Barrera-Ocampo, Sönke Arlt, Jakob Matschke, Ursula Hartmann, Berta Puig, Isidró Ferrer, Petra Zürbig, Markus Glatzel, Diego Sepúlveda‐Falla, Holger Jahn   +9 more
openalex   +2 more sources

Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention [PDF]

, 2016
Cansu Agca, Diana Klakotskaia, Todd R. Schachtman, Anthony W.S. Chan, James J. Lah, Yuksel Agca   +5 more
openalex   +1 more source

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. [PDF]

, 1996
Hui Xu, David Sweeney, Paul Greengard, Sam Gandy   +3 more
openalex   +1 more source

Amyloid precursor protein 𝛽CTF accumulates in synapses in sporadic and genetic forms of Alzheimer's disease [PDF]

, 2023
Paula Ferrer‐Raventós, David Puertollano‐Martín, Marta Querol‐Vilaseca, Érika Sánchez‐Aced, Natalia Valle‐Tamayo, Alba Cervantes‐González, Raúl Núñez‐Llaves, Jordi Pegueroles, Oriol Dols‐Icardo, M. Florencia Iulita, Ibán Aldecoa, Laura Molina‐Porcel, Raquel Sánchez‐Valle, Juan Fortea, Olivia Belbin, Sònia Sirisi, Alberto Lleó   +16 more
openalex   +1 more source

Amyloid precursor protein and endosomal‐lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease

The FASEB Journal, 2017
R. Nixon
semanticscholar   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source