Results 221 to 230 of about 82,488 (290)

The inter-organelle cross-talk finely orchestrated in the amyloidogenic processing of amyloid precursor protein in dendritic arborization neurons of <i>Drosophila</i>. [PDF]

Theranostics
Cheng G, Chang J, Ke S, Dai Z, Gong D, Gong H, Zhou W.   +6 more
europepmc   +1 more source

Aerobic Exercise Attenuates Autophagy‐Lysosomal Flux Deficits via β2‐AR‐Mediated ESCRT‐III Subunit CHMP4B in Mice With Human MAPT P301L

Aging Cell, EarlyView.
MAPT accumulation inhibited CHMP4B expression and thus disrupted ESCRT‐III‐mediated autophagosome‐lysosome fusion, which induced a vicious cycle between MAPT aggregation and autophagic deficits. Aerobic exercise could effectively block the vicious cycle and reverse autophagic deficits by promoting the β2‐AR‐RXRα‐CHMP4B‐ESCRT‐III pathway, reducing ...
Shu‐Guang Bi, Haitao Yu, Tian‐Long Gao, Jia‐Jun Wu, Yu‐Ming Mao, Juan Gong, Fang‐Zhou Wang, Liu Yang, Jia Chen, Zi‐Chong Lan, Meng‐Ting Shen, Yun‐Juan Nie, Gao‐Shang Chai   +12 more
wiley   +1 more source

Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease. [PDF]

Aging Dis
Chen J, Chen JS, Li S, Zhang F, Deng J, Zeng LH, Tan J.   +6 more
europepmc   +1 more source

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

Aging Cell, EarlyView.
Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease‐Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single‐nucleus RNA‐seq from human brain tissues identified cholesterol‐related senescence gene co‐expression modules linked to microglial senescence.
Boyang Li, Shaowei Wang, Bilal Kerman, Cristelle Hugo, E. Keats Shwab, Chang Shu, Ornit Chiba‐Falek, Zoe Arvanitakis, Hussein N. Yassine   +8 more
wiley   +1 more source

Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations. [PDF]

Biochem J
Wang J, Fourriere L, Gleeson PA.
europepmc   +1 more source

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, EarlyView.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source

Huperzine A Regulates the Physiological Homeostasis of Amyloid Precursor Protein Proteolysis and Tau Protein Conformation-A Computational and Experimental Investigation. [PDF]

Biology (Basel)
Wongjaikam S, Nopparat C, Boontem P, Panmanee J, Thasana N, Shukla M, Govitrapong P.   +6 more
europepmc   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source