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RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein
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Physiology and pharmacology of amyloid precursor protein.
Pharmacology & Therapeutics, 2022Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in the brains of individuals with Alzheimer's disease (AD)-related pathologies. Aβ has been extensively investigated since the amyloid hypothesis in AD was proposed.
Yoonsuk Cho +4 more
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Not just amyloid: physiological functions of the amyloid precursor protein family [PDF]
Nature Reviews Neuroscience, 2017 Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood.
U. Müller, T. Deller, M. Korte
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Function of amyloid and amyloid protein precursor
Clinical Neurology and Neurosurgery, 1992A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
Joost Haan, Raymund A.C. Roos
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins
Neurodegenerative Diseases, 2006It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte Anliker, Ulrike Müller
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The pharmacology of amyloid precursor protein processing [PDF]
Experimental Gerontology, 2003 The possibility to understand the causes and treat the symptoms of Alzheimer's disease patients is still a great challenge. The triggering events leading to the selective neurodegeneration observed in Alzheimer's brains are not completely understood.
RACCHI, MARCO, GOVONI, STEFANO
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Recognition of the Amyloid Precursor Protein by Human gamma-secretase
, 2019Cleavage of amyloid precursor protein (APP) by the intramembrane protease γ-secretase is linked to Alzheimer's disease (AD). We report an atomic structure of human γ-secretase in complex with a transmembrane (TM) APP fragment at 2.6-angstrom resolution ...
R. Zhou +5 more
semanticscholar +1 more source