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RACK1 and IRE1 participate in the translational quality control of amyloid precursor protein in Drosophila models of Alzheimer's disease. [PDF]
Li Y+5 more
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Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice. [PDF]
Ono M+12 more
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Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance. [PDF]
Özcan GG+6 more
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Function of amyloid and amyloid protein precursor
Clinical Neurology and Neurosurgery, 1992A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
Joost Haan, Raymund A.C. Roos
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins
Neurodegenerative Diseases, 2006It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte Anliker, Ulrike Müller
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The pharmacology of amyloid precursor protein processing [PDF]
The possibility to understand the causes and treat the symptoms of Alzheimer's disease patients is still a great challenge. The triggering events leading to the selective neurodegeneration observed in Alzheimer's brains are not completely understood.
RACCHI, MARCO, GOVONI, STEFANO
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Processing of Amyloid Precursor Protein and Amyloid Peptide Neurotoxicity
Current Alzheimer Research, 2008Alzheimer's disease is characterized by the presence of two types of lesions in brain: neurofibrillary tangles and senile plaques. Intraneuronal neurofibrillary tangles are made of paired helical filaments containing hyperphosphorylated microtubule associated protein tau.
Pierrot Nathalie, Octave Jean-Noël
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