Results 261 to 270 of about 82,488 (290)

Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice. [PDF]

open access: yesHeliyon
Ono M   +12 more
europepmc   +1 more source

Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance. [PDF]

open access: yesiScience
Özcan GG   +6 more
europepmc   +1 more source
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Function of amyloid and amyloid protein precursor

Clinical Neurology and Neurosurgery, 1992
A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
Joost Haan, Raymund A.C. Roos
openaire   +3 more sources

The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins

Neurodegenerative Diseases, 2006
It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte Anliker, Ulrike Müller
openaire   +3 more sources

The pharmacology of amyloid precursor protein processing [PDF]

open access: possibleExperimental Gerontology, 2003
The possibility to understand the causes and treat the symptoms of Alzheimer's disease patients is still a great challenge. The triggering events leading to the selective neurodegeneration observed in Alzheimer's brains are not completely understood.
RACCHI, MARCO, GOVONI, STEFANO
openaire   +2 more sources

Processing of Amyloid Precursor Protein and Amyloid Peptide Neurotoxicity

Current Alzheimer Research, 2008
Alzheimer's disease is characterized by the presence of two types of lesions in brain: neurofibrillary tangles and senile plaques. Intraneuronal neurofibrillary tangles are made of paired helical filaments containing hyperphosphorylated microtubule associated protein tau.
Pierrot Nathalie, Octave Jean-Noël
openaire   +3 more sources

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