Results 21 to 30 of about 20,912 (233)

Alzheimer's Disease; Mechanism, Mutations, and Applications of Nano-Medicine

Frontiers in Bioscience-Landmark, 2023
Background: In the past 10 years, significant progress has been made in understanding the pathogenic chain of events that causes Alzheimer’s disease (AD).
Muhammad Maisam, Muhammad Tahir Khan, Madeeha Shahzad Lodhi, Kejie Mou, Zili Liu, Dongqing Wei   +5 more
doaj   +1 more source

Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell

Marine Drugs, 2021
The proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase releases amyloid-β peptide (Aβ), which deposits in amyloid plaques and contributes to the initial causative events of Alzheimer’s disease (AD).
Jeong-Hyun Yoon, Nayoung Lee, Kumju Youn, Mi Ra Jo, Hyeung-Rak Kim, Dong-Seok Lee, Chi-Tang Ho, Mira Jun   +7 more
doaj   +1 more source

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway.

PLoS ONE, 2018
Honokiol (poly-phenolic lignan from Magnolia grandiflora) is a Sirtuin-3 (SIRT3) activator which exhibit antioxidant activity and augment mitochondrial functions in several experimental models.
Sindhu Ramesh, Manoj Govindarajulu, Tyler Lynd, Gwyneth Briggs, Danielle Adamek, Ellery Jones, Jake Heiner, Mohammed Majrashi, Timothy Moore, Rajesh Amin, Vishnu Suppiramaniam, Muralikrishnan Dhanasekaran   +11 more
doaj   +1 more source

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

Neurobiology of Disease, 2005
In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits.
Valérie Vingtdeux, Malika Hamdane, Marie Gompel, Séverine Bégard, Hervé Drobecq, Antoine Ghestem, Marie-Eve Grosjean, Vesna Kostanjevecki, Pierre Grognet, Eugeen Vanmechelen, Luc Buée, André Delacourte, Nicolas Sergeant   +12 more
doaj   +1 more source

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant   +8 more
doaj   +1 more source

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury [PDF]

Nature Medicine, 2009
Amyloid-beta (Abeta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of Abeta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss ...
David J, Loane, Ana, Pocivavsek, Charbel E-H, Moussa, Rachel, Thompson, Yasuji, Matsuoka, Alan I, Faden, G William, Rebeck, Mark P, Burns   +7 more
openaire   +2 more sources

The γ-secretase complex: from structure to function

Frontiers in Cellular Neuroscience, 2014
One of the most critical pathological features of Alzheimer’s disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein through sequential cleavage by β-
Xian eZhang, Yanfang eLi, Huaxi eXu, Huaxi eXu, Yun-Wu eZhang   +4 more
doaj   +1 more source

Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits

Frontiers in Aging Neuroscience, 2015
gamma-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein, catalyzing the formation of amyloid beta peptides that form amyloid plaques, which contribute to Alzheimer’s disease pathogenesis.
Natalya eGertsik, Danica eChiu, Yueming eLI   +2 more
doaj   +1 more source

Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease

Medical Sciences, 2018
The present review analyzes the results of recent clinical trials of β secretase inhibition in sporadic Alzheimer’s disease (SAD), considers the striking dichotomy between successes in tests of β-site Amyloid Precursor Protein-Cleaving ...
Vladimir Volloch, Sophia Rits
doaj   +1 more source

Apolipoprotein E modulates γ‐secretase cleavage of the amyloid precursor protein [PDF]

Journal of Neurochemistry, 2004
AbstractPolymorphisms in the apolipoprotein E (APOE) gene affect the risk of Alzheimer disease and the amount of amyloid β‐protein (Aβ) deposited in the brain. The apoE protein reduces Aβ levels in conditioned media from cells in culture, possibly through Aβ clearance mechanisms.
Michael C, Irizarry, Amy, Deng, Alberto, Lleo, Oksana, Berezovska, Christine A F, Von Arnim, Matthew, Martin-Rehrmann, Arlene, Manelli, Mary Jo, LaDu, Bradley T, Hyman, G William, Rebeck   +9 more
openaire   +2 more sources