Results 61 to 70 of about 14,023 (271)

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH [PDF]

, 2002
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Christina Sidera, Chibuu Liu, Brian Austen   +2 more
core   +1 more source

The link between sarcopenic obesity and Alzheimer's disease: a brain‐derived neurotrophic factor point of view

The Journal of Physiology, EarlyView.
Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland, Paul J. LeBlanc, Paula Duarte‐Guterman, Val A. Fajardo, Rebecca E. K. MacPherson   +4 more
wiley   +1 more source

β-Amyloid: The Key Peptide in the Pathogenesis of Alzheimer’s Disease

Frontiers in Pharmacology, 2015
The amyloid β peptide (Aβ) is a critical initiator that triggers the progression of Alzheimer’s Disease (AD) via accumulation and aggregation, of which the process may be caused by Aβ overproduction or perturbation clearance. Aβ is generated from amyloid
Xiaojuan eSun, Wei-Dong eChen, Yan-Dong eWang   +2 more
doaj   +1 more source

Looking at Alzheimer’s Disease Pathogenesis from the Nuclear Side

Biomolecules, 2021
Alzheimer’s disease (AD) is a neurodegenerative disorder representing the most common form of dementia. It is biologically characterized by the deposition of extracellular amyloid-β (Aβ) senile plaques and intracellular neurofibrillary tangles ...
Laura D’Andrea, Ramona Stringhi, Monica Di Luca, Elena Marcello   +3 more
doaj   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Intraneuronal Aβ immunoreactivity is not a predictor of brain amyloidosis-β or neurofibrillary degeneration [PDF]

, 2007
Amyloid β (Aβ) immunoreactivity in neurons was examined in brains of 32 control subjects, 31 people with Down syndrome, and 36 patients with sporadic Alzheimer’s disease to determine if intraneuronal Aβ immunoreactivity is an early manifestation of ...
Jerzy Wegiel, Izabela Kuchna, Krzysztof Nowicki, Janusz Frackowiak, Bozena Mazur-Kolecka, Humi Imaki, Jarek Wegiel, Pankaj D. Mehta, Wayne P. Silverman, Barry Reisberg, Mony deLeon, Thomas Wisniewski, Tuula Pirttilla, Harry Frey, Terho Lehtimäki, Tarmo Kivimäki, Frank E. Visser, Wouter Kamphorst, Anna Potempska, David Bolton, Julia R. Currie, David L. Miller, D Allsop, BA Bahr, KR Bales, C Bancher, M Bobinski, H Braak, H Braak, J Busciglio, DH Chui, DG Cook, MR D’Andrea, J Frackowiak, J Frackowiak, J Frackowiak, C Glabe, M Goedert, GK Gouras, E Gowing, JP Greenfield, I Grundke-Iqbal, DC Guiroy, KA Gyure, C Haass, C Haass, T Hartmann, BT Hyman, H Ito, K Iqbal, KS Kim, KS Kim, T Kitamoto, I Kuchna, CA Lemere, CL Masters, CA McLean, DL Miller, A Mochizuki, C Mori, GM Murphy, IL Payan, G Perry, CJ Pike, A Potempska, B Reisberg, B Reisberg, WI Rosenblum, TC Saido, C Schwab, O Schweers, N Sergeant, R Shapira, JG Sheng, DK Sokol, RA Stern, M Tabaton, RH Takahashi, RH Takahashi, R Wang, J Wegiel, J Wegiel, C Wild-Bode, CA Wilson, O Wirths, KE Wisniewski, H Xu, H Yamaguchi   +87 more
core   +2 more sources

Specific Lipid Peroxidation Products in Erythrocytes and Their Relationship to the Pathogenesis of Alzheimer's Disease

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Alzheimer's disease (AD) is a highly complex and multifactorial disorder in which oxidative stress acts as a key amplifying mechanism in the disease progression. Lipofuscin‐like pigments (LFP), end products of lipid peroxidation, reflect oxidative damage and are capable of crossing the blood–brain barrier into the circulation.
Lenka Martináková, Zuzana Chmátalová, Kateřina Veverová, Vanesa Jurášová, Alžběta Katonová, Martina Laczó, Jan Laczó, Martin Vyhnálek, Jakub Hort, Alice Skoumalová   +9 more
wiley   +1 more source

The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

Neurobiology of Disease, 2016
The processing of amyloid precursor protein (APP) into β-amyloid peptide (Aβ) is a key step in the pathogenesis of Alzheimer’s disease (AD), and trafficking dysregulations of APP and its secretases contribute significantly to altered APP processing. Here
Miao Sun, Suwaiba Z. Asghar, Huaye Zhang
doaj   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, Volume 13, Issue 8, 9 February 2026.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Nonspecificity of Binding of γ-Secretase Modulators to the Amyloid Precursor Protein [PDF]

Biochemistry, 2009
Evidence that certain gamma-secretase modulators (GSMs) target the 99-residue C-terminal domain (C99) of the amyloid precursor protein, a substrate of gamma-secretase, but not the protease complex itself has been presented [Kukar, T. L., et al. (2008) Nature 453, 925-929].
Andrew J, Beel, Paul, Barrett, Paul D, Schnier, Stephen A, Hitchcock, Dhanashri, Bagal, Charles R, Sanders, John B, Jordan   +6 more
openaire   +2 more sources