Results 81 to 90 of about 14,023 (271)
BRICHOS interactions with amyloid proteins and implications for Alzheimer disease [PDF]
, 2016 To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect failure of the cell to manage ...
Dolfe, Lisa
core +1 more source
The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2018 The retromer complex and associated sorting nexins (SNXs) comprise a critical trafficking machinery which mediates endosomal protein sorting. Retromer and/or SNX dysfunction has been linked to several neurodegenerative diseases including Alzheimer’s ...
Hongfeng Zhang +8 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath +9 more
wiley +1 more source
Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine [PDF]
, 2013 BACKGROUND: Currently available therapies for Alzheimer's disease (AD) do not treat the underlying cause of AD. Anecdotal observations in nursing homes from multiple studies strongly suggest an inverse relationship between cancer and AD.
Adel Nefzi +7 more
core +1 more source
Shedding of APP limits its synaptogenic activity and cell adhesion properties
Frontiers in Cellular Neuroscience, 2014 The Amyloid precursor protein (APP) plays a central role in Alzheimer’s disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its ...
Ronny eStahl +9 more
doaj +1 more source
iScience, 2021 Summary: Despite intuitive insights into differential proteolysis of amyloid precursor protein (APP), the stochasticity behind local product formation through amyloidogenic pathway at individual synapses remain unclear.
Shekhar Kedia +10 more
doaj +1 more source
Mutations Alter Conformations and Dynamics of APP‐TMDs: An RDC Analysis
ChemistryEurope, Volume 4, Issue 2, February 2026.How γ‐secretase selects its substrates has been an enigma because of the lack of a consensus sequence. Using residual dipolar couplings, we analyzed the conformations of one substrate and two mutants. Using snapshots of a molecular dynamics trajectory, we analyzed how well structures matched the measured RDC values.
Franziska Krause +7 more
wiley +1 more source
Endosomal Sorting of Amyloid Precursor Protein‐P‐Selectin Chimeras Influences Secretase Processing [PDF]
Traffic, 2001 Amyloid β protein, the major component of the senile plaques in Alzheimer's disease, is generated by secretory and endocytic processing of amyloid precursor protein. Internalized amyloid precursor protein either recycles to the plasma membrane, where α‐secretase resides, or moves to acidic compartment(s) for β‐secretase exposure.
B L, Daugherty, S A, Green
openaire +2 more sources
SUMOylation: novel neuroprotective approach for Alzheimer's disease? [PDF]
, 2015 Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized in the brain by the formation of amyloid-beta (Aβ)-containing plaques and neurofibrillary tangles containing the microtubule-associated protein tau.
Cimarosti, Helena +2 more
core +1 more source
Frontiers in Psychiatry, 2019 The most replicated neuroanatomical finding in autism is the tendency toward brain overgrowth, especially in younger children. Research shows that both gray and white matter are enlarged.
Deborah K. Sokol +4 more
doaj +1 more source