Results 151 to 160 of about 125,062 (284)

Free‐Breathing, 3D Cardiac Magnetic Resonance Elastography for Myocardial Stiffness Mapping

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 2356-2369, April 2026.
ABSTRACT Purpose Magnetic resonance elastography (MRE) of the heart has predominantly utilized breath‐held acquisitions with limited anatomic coverage. This work investigates the feasibility of 3D, free‐breathing cardiac MRE. Methods A 3D hybrid radial and EPI acquisition is utilized and combined with retrospective binning of k‐space via physiologic ...
Nolan K. Meyer, Yi Sui, Jessica Magnuson, Phillip J. Rossman, Kevin J. Glaser, Matthew C. Murphy, Armando Manduca, Ian C. Chang, Kiaran P. McGee, Kejal Kantarci, Ekta Kapoor, Philip A. Araoz, Richard L. Ehman, Joshua D. Trzasko, Arvin Arani   +14 more
wiley   +1 more source

Multimodal MRI Reveals Cerebral and Vascular Amyloid‐Driven Myeloarchitectural Disorganization in a Mouse Model of Alzheimer's Disease

NMR in Biomedicine, Volume 39, Issue 4, April 2026.
This study investigates the effect of cerebral and vascular (beta‐amyloid) Aβ on regional myeloarchitecture and lipid composition in a murine model of Alzheimer's disease (AD). The study highlights the feasibility of quantitative MRI and chemical exchange saturation transfer (CEST) imaging to identify multiple biophysical mechanisms involved in ...
Syed Salman Shahid, Xuan Li, Mario Dzemidzic, Erin E. Jarvis, Yomna Takieldeen, Aibo Wang, Donna Wilcock, Yu‐Chien Wu   +7 more
wiley   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Validity of Amyloidosis in the Danish National Patient Registry. [PDF]

Clin Epidemiol
Skov JK, Sikandar U, Bonnesen K, Poulsen SH, Schmidt M.   +4 more
europepmc   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Nodular Pulmonary Amyloidosis Associated With Sjögren's Syndrome. [PDF]

Cureus
Borrego R, Soveral A, André S.
europepmc   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

A retrospective real-world study assessing diagnostic pattern of light-chain amyloidosis in Japan based on data from the medical data vision claims database. [PDF]

Ther Adv Hematol
Yogo M, Kasahara-Kiritani M, Oshima K, Ishida T.   +3 more
europepmc   +1 more source

Lichen amyloidosis [PDF]

Canadian Medical Association Journal, 2013
Barry, Ladizinski, Kachiu Cecilia, Lee
openaire   +2 more sources

Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases

Aggregate, Volume 7, Issue 3, March 2026.
Amyloid‐ID, a ThT‐like photocatalytic probe, enables proteotyping of amyloid deposits by ROS‐mediated protein labeling. Applied to patient biopsies, amyloid‐ID identifies potential fibrinogen‐derived amyloid in laryngeal amyloidosis, revealing a mechanically sensitive fibrillation mechanism linked to vocal cord friction.
Huan Feng, Fangliang Guo, Yan Wang, Meng You, Qiuxuan Xia, Wang Wan, Di Shen, Kaini Shen, Xin Zhang, Wei Li, Yu Liu   +10 more
wiley   +1 more source