Results 121 to 130 of about 27,543 (304)

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Targeted Regeneration of Bone in the Osteoporotic Human Femur

, 2011
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system.
Gerard R. Ridgway, Poole, KES, Kenneth E. S. Poole, Borggrefe, J, Paul M Mayhew, Treece, GM, Ridgway, GR, Paul M. Mayhew, Andrew H. Gee, Graham M Treece, Mayhew, PM, Gee, AH, Graham M. Treece, Andrew H Gee, Gerard R Ridgway, Jan Borggrefe, Kenneth E S Poole   +16 more
core   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Neuromuscular Electrical Stimulation to Combat Muscle Atrophy During Spaceflight: A Narrative Review of Mechanisms and Potential Applications

Life
As humanity continues to strive for extraplanetary exploration, which is quickly gaining marked governmental and industrial support and recognition, there are still substantial detriments to astronaut health during long-duration spaceflight (i.e., muscle
Broderick L. Dickerson, Ryan J. Sowinski, Drew E. Gonzalez   +2 more
doaj   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Increased microbial anabolism contributes to soil carbon sequestration by mineral fertilization in temperate grasslands

, 2019
Ecosystem responses to nitrogen (N) additions are manifold and complex, and also affect the carbon (C) cycle. It has been suggested that increased microbial carbon use efficiency (CUE), i.e.
Helfrich, Mirjam, Don, Axel, Korevaar, Hein, Tebbe, Christoph, Zopf, Dorit, Poeplau, Christopher, Tebbe, Christoph C., Greiner, Bärbel, Dechow, Rene, Szoboszlay, Márton, Thumm, Ulrich, Geerts, Rob   +11 more
core   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training

, 2008
Purpose of Review: Sarcopenia (skeletal muscle wasting with aging) is thought to underlie a number of serious age-related health issues. While it may be seen as inevitable, decreasing this gradual loss of muscle is vital for healthy aging.
Hayes, Alan, Cribb, Paul J
core  

A leucine supplementation after an immobilization-induced atrophy in old rats enhanced protein anabolism but failed in muscle mass recovery

, 2013
By contrast to adult, we have shown (Magne et al. 2011) that immobilization during ageing generated muscle atrophy which is not recovered. This is not due to a sustained muscle proteolysis since it was rapidly normalized.
Magne, Hugues, Combaret, Lydie, Dardevet, Dominique, Savary-Auzeloux, Isabelle, Sornet, Claire, Migne, Carole   +5 more
core   +1 more source