Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases [PDF]
Cell & Bioscience, 2021 Background In the urgent campaign to develop therapeutics against SARS-CoV-2, natural products have been an important source of new lead compounds. Results We herein identified two natural products, ginkgolic acid and anacardic acid, as inhibitors using ...
Zinuo Chen +9 more
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Anacardic Acid Constituents from Cashew Nut Shell Liquid: NMR Characterization and the Effect of Unsaturation on Its Biological Activities [PDF]
Pharmaceuticals, 2017 Anacardic acids are the main constituents of natural cashew nut shell liquid (CNSL), obtained via the extraction of cashew shells with hexane at room temperature.
Selene M. Morais +6 more
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The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding [PDF]
Frontiers in Microbiology, 2019 The ubiquitous and highly abundant glycolytic enzyme D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pivotal for the energy and carbon metabolism of most organisms, including human pathogenic bacteria.
Sara Gómez +11 more
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Transcriptomic response of breast cancer cells to anacardic acid. [PDF]
Sci Rep, 2018 AbstractAnacardic acid (AnAc), a potential dietary agent for preventing and treating breast cancer, inhibited the proliferation of estrogen receptor α (ERα) positive MCF-7 and MDA-MB-231 triple negative breast cancer cells. To characterize potential regulators of AnAc action, MCF-7 and MDA-MB-231 cells were treated for 6 h with purified AnAc 24:1n5 ...
Schultz DJ +6 more
europepmc +4 more sources
Genome-wide miRNA response to anacardic acid in breast cancer cells. [PDF]
PLoS ONE, 2017 MicroRNAs are biomarkers and potential therapeutic targets for breast cancer. Anacardic acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) positive and MDA-MB-231 triple negative breast cancer (TNBC) cell ...
David J Schultz +6 more
doaj +2 more sources
Anacardic Acid Reduces Acetylation Of H4K12 In Mouse Oocytes During Vitrification [PDF]
Cell Journal, 2018 Objective Over the last years, vitrification has been widely used for oocyte cryopreservation, in animals and humans; however, it frequently causes minor and major epigenetic modifications.
Alaleh Ghazifard +8 more
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Anacardic acid enhances the proliferation of human ovarian cancer cells. [PDF]
PLoS ONE, 2014 BACKGROUND: Anacardic acid (AA) is a mixture of 2-hydroxy-6-alkylbenzoic acid homologs. Certain antitumor activities of AA have been reported in a variety of cancers. However, the function of AA in ovarian cancer, to date, has remained unknown.
Yin-Ling Xiu +5 more
doaj +2 more sources
Anacardic acid derivatives from brazilian propolis and their antibacterial activity
Eclética Química, 2018 Propolis is a sticky, gummy, resinous substance collected by honeybees (Apis mellifera L.) from various plant sources, which has excellent medicinal properties.
M. S. S. Silva +6 more
doaj +4 more sources
Synthesis of Isochromans From Anacardic Acids Obtained From Cashew Nutshell Liquid (CNSL) and Their Antimicrobial Activity. [PDF]
Chem BiodiversUtilizing anacardic acid derived from cashew nut shell liquid, the synthesis of isochromans was accomplished. Two key steps were exploited. Firstly, a benzylic bromination in the green solvent tert‐butyl acetate is disclosed. Secondly, as an example, the exposure of the secondary alcohol 1‐(2‐methoxy‐6‐(pentadec‐1‐en‐1‐yl)phenyl)ethanol to potassium t ...
Davids BL +5 more
europepmc +2 more sources