Results 121 to 130 of about 70,398 (322)

Vitexin Attenuates the Growth and Glycolysis of Acute Myeloid Leukemia Cells by Suppressing the HIF‐1α‐Modulated YAP Pathway Under Hypoxic Conditions

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vitexin, an apigenin flavone glycoside, exhibits antitumor activity against various cancers including leukemia. Hypoxia enhances glycolysis, thereby promoting tumor growth. In this study, we aimed to explore the effects of vitexin on hypoxia‐induced growth and glycolysis in acute myeloid leukemia (AML) cells and determine the underlying ...
Ping Wang, Jia‐Jia Zhang, Fang Zhang, Xiao‐Jie Qu, Hui Zhang   +4 more
wiley   +1 more source

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ferroptosis inhibitor), lactate (LA), sh‐β‐catenin (shRNA of β‐catenin), or SKL2001 (an agonist ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
wiley   +1 more source

Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy. [PDF]

, 2019
Characterization of single cell metabolism is imperative for understanding subcellular functional and biochemical changes associated with healthy tissue development and the progression of numerous diseases.
Aghaamoo, Mohammad, Digman, Michelle A, Kamalakshakurup, Gopakumar, Lee, Abraham P, Ma, Ning   +4 more
core   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

The Role of Tissue Oxygen Tension in Dengue Virus Replication

Cells, 2018
Low oxygen tension exerts a profound effect on the replication of several DNA and RNA viruses. In vitro propagation of Dengue virus (DENV) has been conventionally studied under atmospheric oxygen levels despite that in vivo, the tissue microenvironment ...
Efseveia Frakolaki, Panagiota Kaimou, Maria Moraiti, Katerina I. Kalliampakou, Kalliopi Karampetsou, Eleni Dotsika, Panagiotis Liakos, Dido Vassilacopoulou, Penelope Mavromara, Ralf Bartenschlager, Niki Vassilaki   +10 more
doaj   +1 more source

METABOLISM OF THE DEVELOPING RETINA: I. AEROBIC AND ANAEROBIC GLYCOLYSIS IN THE DEVELOPING RAT RETINA [PDF]

, 1959
Clive N. Graymore
openalex   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Emerging Biomedical Engineering Therapies for Infected Diabetic Foot Ulcers: Toward Antibacterial Functionalization and Pathology‐Responsive Regulation

Small Science, EarlyView.
Infected diabetic foot ulcer endangers patients with high amputation, disability, mortality risks, and heavy medical burdens. This review analyzes its pathogenic factors, the limitations of current treatments, the breakthroughs of responsive antimicrobial biomaterials, and the challenge of multifunctional biomaterial innovations for further developing ...
Yaqi Yao, Mengyi Huang, Yuetong Li, Yiqi Lin, Junjie Dong, Jianhang Du, Aixia Zhai, Changlong Bi, Luoyuan Li   +8 more
wiley   +1 more source

SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal adenocarcinoma. [PDF]

J Exp Clin Cancer Res, 2023
Lin J, Liu Y, Liu P, Qi W, Liu J, He X, Liu Q, Liu Z, Yin J, Lin J, Bao H, Lin J.   +11 more
europepmc   +1 more source

The Power of Yeast

Yeast, EarlyView.
ABSTRACT Yeasts have been intimately connected with human civilization for millennia, originally used for fermentation in food and beverage production. This article explores the multifaceted roles of yeasts—particularly Saccharomyces cerevisiae—as both a model organism and a cell factory.
Jens Nielsen
wiley   +1 more source