Results 141 to 150 of about 625,843 (401)

Gabapentin for pain management after osmotic dilator insertion and prior to dilation and evacuation: A randomized controlled trial. [PDF]

open access: yes, 2020
ObjectiveTo evaluate if gabapentin 600 mg reduces pain after osmotic dilator placement the day before a dilation and evacuation (D&E) procedure.Study designWe conducted a double-blind, placebo-controlled, randomized (stratified by vaginal parity ...
Chen, Melissa J   +5 more
core   +3 more sources

Light Mediated Sulfonylation/C–H Activation/Annulation of Benzimidazoles Derivatives Catalyzed by Diarylmethylium Tetrafluoroborate Salts: An Experimental and Computational Study

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Through the exploiting of visible‐light, a key photoactive complex, and an acid‐catalyzed proton‐coupled electron transfer, polycyclic sulfonylated benzimidazoles are obtained through a domino process including sulfonylation, C–H activation, and annulation. Diarylmethylium tetrafluoroborates are employed as inexpensive organocatalyst capable of forming
Polyssena Renzi   +4 more
wiley   +1 more source

Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models

open access: yesFrontiers in Pharmacology
IntroductionPain is a complex phenomenon involving physiological and psychological responses to noxious stimuli. Long-term opioid or NSAID use leads to reduced efficacy and tolerance. Initially a thermosensitive receptor, TRPV1 is increasingly recognized
Hanbin Chen   +18 more
doaj   +1 more source

"Pharmacology of salicin derivatives in sheep" : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 2016
Content removed from thesis due to copyright reasons: Figure 1.20(e). S. viminalis. Retrieved from Valerie J.:http://gardeners-word.blogspot.co.uk/Sheep suffer from pain during various husbandry practices as well as during injury or diseases such as ...
Mathurkar, Shashwati Chandrakant
core  

Photoredox‐Catalyzed Synthesis of a Novel Class of Fluoroalkyl Pyrazolones

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
A photoredox strategy enables regioselective synthesis of fluoroalkyl 2‐pyrazolin‐5‐ones via radical addition and cyclization. This mild, metal‐free method shows a broad substrate scope, operates in batch and flow systems, and offers a sustainable approach to fluorinated heterocycles with potential applications in medicinal chemistry.
Emanuele F. Pissinati   +3 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

open access: yesAdvanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma   +10 more
wiley   +1 more source

From acute to chronic pain: tapentadol in the progressive stages of this disease entity [PDF]

open access: yes, 2017
OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity.
Coluzzi, Flaminia   +3 more
core  

ANALGESIC ACTION OF PETHIDINE DERIVATIVES AND RELATED COMPOUNDS [PDF]

open access: bronze, 1946
Alex MacDonald   +4 more
openalex   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

open access: yesAdvanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi   +15 more
wiley   +1 more source

INFLUENCE OF ANALGESICS ON PAIN INTENSITY DURING LABOR [PDF]

open access: bronze, 1951
Carl T. Javert, James D. Hardy
openalex   +1 more source

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