Results 191 to 200 of about 625,843 (401)

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

Advanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang, Di Mu, Su Liu, Peng‐Bo Jing, Bin Wu, Xiao‐Mei Yang, Jia‐Yi Ge, Qing‐Yi Li, Hao‐Hao Chen, Feng‐Ming Zhang, Bing Wang, Ying‐Ying Zhang, Linnan Qian, Zi‐Yi Zhu, Yu‐Sen Ou, Shi‐Yu Sun, Lin Luo, Yu Feng, Changyu Jiang, Zhuo Sun, Yong Chen, Hai‐Li Pan, Bin Wang, Fen‐Fei Gao, Jie Wu, Zhigang Lu, Tong Liu, Yan‐Gang Sun, Xing‐Jun Liu   +28 more
wiley   +1 more source

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

Advanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao, Kaixi Shi, Wen Li, Jialin Liu, Pengfei Xie, Zijun Hu, Yu Dai, Haiyan Weng, Qiuju Yuan, Wutian Wu, Limin Rong, Liumin He   +11 more
wiley   +1 more source

Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010.

JAMA Internal Medicine, 2014
M. Bachhuber, B. Saloner, C. Cunningham, Colleen L. Barry   +3 more
semanticscholar   +1 more source

Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A selenomethionine‐derived carbon dot (Se‐Met‐CD) serves as a potent nano‐antioxidant, efficiently scavenging reactive oxygen species, protecting nucleus pulposus cells from oxidative damage, restoring extracellular matrix homeostasis, and significantly mitigating intervertebral disc degeneration in vivo, which demonstrates great promise as a nanozyme ...
Qingzheng Zhang, Zongtai Liu, Yirong Sun, Changfeng Fu, Jianxun Ding   +4 more
wiley   +1 more source

STUDIES ON SITES OF ACTION OF ANALGESICS

, 1954
S. FUJITA, Motohiro Yasuhara, Shigeru Yamamoto, Kikuo Ogiu   +3 more
openalex   +1 more source

High‐Density Flexible Neural Implants with Submicron Feedline Resolution

Advanced Electronic Materials, EarlyView.
Optimization of microfabrication methods using optical contact lithography (OCL) and electron beam lithography (EBL) enables the fabrication of 64‐channel, high‐density, parylene‐C‐based intracortical implants with submicron feedlines as narrow as 400 and 50 nm, respectively.
Lina Koschinski, Thomas Grap, Erkan Yilmaz, Marius Kleutgens, Simon Decke, Martin Kasavetov, Marie Jung, Alejandro Carnicer‐Lombarte, George Malliaras, Andreas Offenhäusser, Viviana Rincón Montes   +10 more
wiley   +1 more source

A Significant Decline in the Number of Newly Dispensed Analgesics During the First COVID-19 Lockdown in The Netherlands. [PDF]

Eur J Pain
Zijlstra MN, Kiani P, Hendriksen PA, Dijkgraaf DM, Garssen J, Verster JC.   +5 more
europepmc   +1 more source

Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future

Advanced Intelligent Systems, EarlyView.
Many discussions of artificial intelligence fail to address deeper questions being raised by advances in developmental biology, neuroscience, bioengineering, and philosophy of mind. Novel beings, including technologically and biologically augmented humans, engineered life forms, hybrots, and others, require tools of the emerging field of diverse ...
Michael Levin
wiley   +1 more source

The effectiveness of a multisite, multidisciplinary analgesic stewardship program: a 12-month retrospective cohort study. [PDF]

Pain Rep
Szmerling J, Maleki S, Mar G, Gu G, Schembri E, Buntine P, Goulopoulos A, Owen PJ.   +7 more
europepmc   +1 more source

Highly Efficient Classification of Time‐Series Based on Resistive Switching Cluster‐Assembled Materials

Advanced Intelligent Systems, EarlyView.
Cluster‐assembled nanocomposite devices are employed for the classification of neuronal traces, without any preprocessing of the input time‐series or prior training of the nonlinear devices. The classification method relies on the statistical analysis of the device's output time‐series, achieving higher classification accuracy compared to more energy ...
Filippo Profumo, Francesca Borghi, Tommaso Angì, Marta Maschietto, Stefano Vassanelli, Paolo Milani   +5 more
wiley   +1 more source