Results 191 to 200 of about 583,318 (388)
Animal Models and Experimental Medicine, EarlyView.A novel, simple coccygeal intervertebral disc degeneration model, using a suturing method for tail‐looping, without the need for external fixation and complex surgery. The model has high reproducibility and stability and overcomes the disadvantages of the existing animal models of disc degeneration.
Wei Xie +11 more
wiley +1 more source
From acute to chronic pain: tapentadol in the progressive stages of this disease entity [PDF]
, 2017 OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity.
Coluzzi, Flaminia +3 more
core
Animal models of cisplatin‐induced neuropathic pain
Animal Models and Experimental Medicine, EarlyView.This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li +9 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin +9 more
wiley +1 more source
Nitrogen‐Centered Organic Persistent Radicals Catalyze Redox‐Neutral C─C Bond Forming Reactions
Angewandte Chemie, EarlyView.Kuhn verdazyls, discovered over 60 years ago, are shown as effective catalysts for the first time. Their tunable redox properties enable organocatalytic redox‐neutral C─H arylation and C─H trifluoromethylation reactions without light activation.
Shrouq Mujahed +4 more
wiley +2 more sources
Breaking barriers to novel analgesic drug development
Nature reviews. Drug discovery, 2017 Ajay S. Yekkirala +3 more
semanticscholar +1 more source
A mouse model of lung ischemia–reperfusion injury with reversible left hilar entrapment
Animal Models and Experimental Medicine, EarlyView.A Novel Reversible Left Hilar Entrapment Model for Mouse Lung Ischemia‐Reperfusion Injury with Visual Tracheal Intubation and Live Knot Technique. Abstract Lung ischemia–reperfusion injury (LIRI), an acute lung injury syndrome triggered by lung transplantation or distal organ ischemia, has long been a difficult and hot issue in clinical research.
GuangDong Weng +4 more
wiley +1 more source
Platinum‐Catalysed Hydrofluorination of Alkynes at Room Temperature Promoted by a Fluoride Shuttle
Angewandte Chemie, EarlyView.This work presents an air and moisture tolerant platinum‐catalysed hydrofluorination system that gives selectively (Z)‐fluoroalkenes. Experimental and computational investigation on the mechanism allowed for the identification of catalytic species. The hydrofluorination is mediated by complexes between the fluorinated anion and HF, resulting into BF3 ...
Ouchan He +5 more
wiley +2 more sources