Low‐intervention clinical trials in Spain: Do they progress?
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza +4 more
wiley +1 more source
Effect of the rs7858836 Single-Nucleotide Polymorphisms of the ASTN2 Gene on Pain-Related Phenotypes in Japanese Women Who Underwent Laparoscopic Gynecologic Surgery. [PDF]
Inoue R +9 more
europepmc +1 more source
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko +9 more
wiley +1 more source
Effectiveness of Non-Pharmacological Interventions for Pain Management After Laparoscopic Cholecystectomy: A Systematic Review and Network Meta-Analysis. [PDF]
Lei T, Peng Y, Liu Y, Xie Y, Wang J.
europepmc +1 more source
Good Practice in Postoperative and Procedural Pain Management 2nd Edition [PDF]
CARTER, BERNIE +10 more
core
Abstract This article examines how UK and US universities manage racial equality regimes through governance structures that prioritise institutional reputation over substantive racial justice reform. Drawing on Bourdieu's field, habitus and capital theory, the study demonstrates how universities neutralise racial justice efforts through bureaucratic ...
David Roberts
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Postoperative opioid-free analgesia with acetaminophen and its impact on pain and postoperative nausea and vomiting following arthroscopic rotator cuff repair: a single-center retrospective study. [PDF]
Okizuka M +6 more
europepmc +1 more source
Matching actual treatment with patient administration-route-preference improves analgesic response among acute-low-back-pain patients [PDF]
Adi Shani +4 more
openalex +1 more source
Dynamic Immune Cell Composition, Phenotypes, and Signaling in an Engineered Metastatic Niche
ABSTRACT In breast cancer patients, metastasis is the stage of disease where prognosis significantly worsens. However, the timing at which metastasis initiates and the location of metastatic lesions in an organ are stochastic, limiting the timely identification of disease and the administration of treatments.
Rebecca S. Pereles +6 more
wiley +1 more source

