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Opioid analgesics: Managing the predictable. [PDF]
Clin Med (Lond)Barnes A +2 more
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Implementation of a Statewide Fentanyl Possession Law and Opioid-Related Overdose Deaths.
JAMA Health ForumJurecka C +8 more
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Semi-synthesis in the exploration of opioid-targeting natural products.
Nat Prod RepRiley AP.
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Opioid and non-opioid analgesics
Best Practice & Research Clinical Anaesthesiology, 2003Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Gail Gillespie +2 more
openaire +3 more sources
Veterinary Clinics of North America: Small Animal Practice, 2000
Opioids are useful and potent drugs for the management of pain in small animal patients. They have a wide therapeutic index and can be given by a number of different routes. Some of these techniques (e.g., epidural and intraarticular) allow for the production of profound analgesia in a localized area of the body while limiting the dose and the side ...
openaire +2 more sources
Opioids are useful and potent drugs for the management of pain in small animal patients. They have a wide therapeutic index and can be given by a number of different routes. Some of these techniques (e.g., epidural and intraarticular) allow for the production of profound analgesia in a localized area of the body while limiting the dose and the side ...
openaire +2 more sources
Anaesthesia & Intensive Care Medicine, 2011
Abstract When it was first discovered in the 1500s, opium was heralded as the most potent analgesic. The Latin name for morphine tincture, laudanum (to praise), illustrates the high regard in which it was held. The many adverse effects associated with its use (now attributed to non-specific opioid receptor cross-activation between subtypes ...
David G. Lambert +3 more
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Abstract When it was first discovered in the 1500s, opium was heralded as the most potent analgesic. The Latin name for morphine tincture, laudanum (to praise), illustrates the high regard in which it was held. The many adverse effects associated with its use (now attributed to non-specific opioid receptor cross-activation between subtypes ...
David G. Lambert +3 more
openaire +2 more sources
On subclasses of opioid analgesics
Current Medical Research and Opinion, 2014The history of discovery of analgesic drugs has followed a trajectory from original serendipitous discovery of plant-derived substances to laboratory creation of customized molecules that are intentionally designed to interact with specific receptors of neurotransmitters involved in either the transmission of the pain signal or the attenuation of such ...
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The American Journal of Medicine, 1984
The clinical pharmacology of the narcotic-type analgesics is discussed in depth. Relative analgesic potency, peak and duration of analgesia, oral potency, and adverse effects are reviewed, With an emphasis on the clinical application of this knowledge.
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The clinical pharmacology of the narcotic-type analgesics is discussed in depth. Relative analgesic potency, peak and duration of analgesia, oral potency, and adverse effects are reviewed, With an emphasis on the clinical application of this knowledge.
openaire +3 more sources