Fifty-five healthy conscious dogs were included in a prospective randomised double-blinded clinical study. The dogs allocated to one of four groups received intravenous bolus followed by infusion of fentanyl (FEN-group), or ketamine (KET-group), or ...
P Rauser+4 more
doaj +1 more source
Discontinuation of Long-term Opioid Analgesics was responsible for developing the HHS Guide for Clinicians on the Appropriate Dosage Reduction or Discontinuation of Long-Term Opioid Analgesics. Deborah (US Centers for and Christopher PharmD, DrPH and MPE
D. Dowell, W. Compton, B. Giroir
semanticscholar +1 more source
Analgesic prescribing trends in a national sample of older veterans with osteoarthritis: 2012-2017 [PDF]
Few investigations examine patterns of opioid and nonopioid analgesic prescribing and concurrent pain intensity ratings before and after institution of safer prescribing programs such as the October 2013 Veterans Health Administration system-wide Opioid ...
Bair, Matthew J.+7 more
core +1 more source
Preclinical and Clinical Pharmacology of Hydrocodone for Chronic Pain: A Mini Review
Hydrocodone is one of the most prescribed oral analgesic drugs and it is one of the most abused drugs in general population. It is a mu-opioid agonist predominantly metabolized to the O-demethylated product hydromorphone and to the N-demethylated product
Luigi Cardia+7 more
doaj +1 more source
Comparative Evaluation of Different Parenteral Agents as Postoperative Analgesics among Patients of Lichtenstein Repair: A Prospective Observational Study [PDF]
Introduction: Hernia surgery is one of the most frequently done surgeries worldwide. It is of special concern since, the postoperative pain can be because of injury to the nerves apart from the skin incision.
Rohit Srivastava+5 more
doaj +1 more source
Addressing the Global Tragedy of Needless Pain: Rethinking the United Nations Single Convention on Narcotic Drugs [PDF]
The lack of medical availability of effective pain medication is an enduring and expanding global health calamity. Despite important medical advances, pain remains severely under-treated worldwide, particularly in developing countries.
Allyn L. Taylor+11 more
core +2 more sources
It is the responsibility of the professional care team to develop an effective person-centred Pain Management strategy which appropriately assesses patients, analyses the results of the assessment and devises a person centred plan to manage pain while ...
M. Botea
semanticscholar +1 more source
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]
© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta+9 more
core +2 more sources
An interpretable boosting model to predict side effects of analgesics for osteoarthritis
BackgroundOsteoarthritis (OA) is the most common disease of arthritis. Analgesics are widely used in the treat of arthritis, which may increase the risk of cardiovascular diseases by 20% to 50% overall.There are few studies on the side effects of OA ...
Liangliang Liu+7 more
semanticscholar +1 more source
Harms and benefits associated with psychoactive drugs: findings of an international survey of active drug users. [PDF]
There have been several recent efforts in the UK and the Netherlands to describe the harms of psychoactive substances based on ratings of either experts or drug users.
Morgan, CJ+4 more
core +2 more sources