Results 51 to 60 of about 449,058 (420)
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]
, 2019 © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta +9 more
core +3 more sources
Deficits in pain medication in older adults with chronic pain receiving home care: A cross-sectional study in Germany [PDF]
, 2020 OBJECTIVE: To analyze the pattern and appropriateness of pain medications in older adults receiving home care. METHODS: We performed a prospective cross-sectional study in patients ≥65 years old having chronic pain and receiving home care in Berlin ...
Algharably, Engi +5 more
core +1 more source
Joint Distribution and Transitions of Pain and Activity in Critically Ill Patients [PDF]
, 2020 Pain and physical function are both essential indices of recovery in critically ill patients in the Intensive Care Units (ICU). Simultaneous monitoring of pain intensity and patient activity can be important for determining which analgesic interventions can optimize mobility and function, while minimizing opioid harm. Nonetheless, so far, our knowledge
arxiv +1 more source
Perspectives in Clinical Research, 2021 Background and Aims: Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.
Shirish Joshi +6 more
doaj +1 more source
Old Drugs for JAK-STAT Pathway Inhibition in COVID-19 [PDF]
, 2020 The pandemic threat of COVID-19 with more than 37 million cases in which about 5 percent entering critical stage characterized by cytokine storm and hyperinflammatory condition, the state more often leads to admission to intensive care unit with rapid mortality.
arxiv +1 more source
Short-term prospective memory deficits in chronic back pain patients [PDF]
, 2007 Objective: Chronic pain, particularly low back pain, is widespread. Although a great deal is known about the impact that this has on quality of life and physical activity, relatively little has been established regarding the more cognitive effects of ...
+38 more
core +1 more source
Can a microscopic stochastic model explain the emergence of pain cycles in patients? [PDF]
, 2008 A stochastic model is here introduced to investigate the molecular mechanisms which trigger the perception of pain. The action of analgesic drug compounds is discussed in a dynamical context, where the competition with inactive species is explicitly accounted for.
arxiv +1 more source
Psychotropics, Antidepressants, and Visceral Analgesics in Functional Gastrointestinal Disorders
Current Gastroenterology Reports, 2018 Purpose of ReviewThe functional gastrointestinal disorders, or disorders of gut-brain interaction as defined by the Rome IV criteria, are the most common diagnostic entities in gastroenterology.
H. Törnblom, D. Drossman
semanticscholar +1 more source
Binding Pathway of Opiates to $μ$ Opioid Receptors Revealed by Unsupervised Machine Learning [PDF]
, 2018 Many important analgesics relieve pain by binding to the $\mu$-Opioid Receptor ($\mu$OR), which makes the $\mu$OR among the most clinically relevant proteins of the G Protein Coupled Receptor (GPCR) family. Despite previous studies on the activation pathways of the GPCRs, the mechanism of opiate binding and the selectivity of $\mu$OR are largely ...
arxiv +1 more source
Brazilian Journal of Anesthesiology, 2012 Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use.
Flores, Murilo Pereira +2 more
openaire +2 more sources