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Fundamental & Clinical Pharmacology, 2006
AbstractEndocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2‐arachidonoylglycerol.
K, Smita +2 more
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AbstractEndocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2‐arachidonoylglycerol.
K, Smita +2 more
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Potentiation of anandamide hypotension by the transport inhibitor, AM404 [PDF]
European Journal of Pharmacology, 1997 The putative endogenous cannabinoid, anandamide (0.2-2 mg/kg i.v.), decreased systemic blood pressure dose-dependently in anesthesized guinea pigs. These effects were prevented by the CB1 cannabinoid receptor antagonist SR141716A [N-(piperidin-1-yl)-5-(4-
Antonio Calignano +2 more
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Oxidative metabolism of anandamide
Prostaglandins & Other Lipid Mediators, 2000In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES.
S H, Burstein +3 more
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Biphasic Effects of Anandamide
Pharmacology Biochemistry and Behavior, 1998Effects of the endogenous cannabimimetic anandamide were assessed over a wide dose range in a series of physiological and behavioral assays. These included the tetrad of tests in mice commonly used to assess cannabinoid-induced effects (motor activity, ring catalepsy, hypothermia, and analgesia tests), as well as a model for agonistic behavior on ...
E, Sulcova, R, Mechoulam, E, Fride
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Enzymes for anandamide biosynthesis and metabolism
Journal of Lipid Mediators and Cell Signalling, 1996Anandamide is an endogenous ligand for cannabinoid receptors. We tried to isolate and purify "anandamide amidohydrolase' which hydrolyzes anandamide to arachidonic acid and ethanolamine. The enzyme activity was found in the microsomal fraction of porcine brain homogenate.
N, Ueda +4 more
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Anandamide vehicles: a comparative study
European Journal of Pharmacology, 2004Among the studies that investigate the vasorelaxation induced by anandamide, one of the most frequent differences is the use of distinct solvents that could modify vascular function and explain the controversial results described. The aims of this study were: to evaluate the influence of different cannabinoid vehicles in vascular function of rat aorta,
Visitación, López-Miranda +4 more
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Anandamide transport: A critical review
Life Sciences, 2005Anandamide (AEA) uptake has been described over the last decade to occur by facilitated diffusion, but a protein has yet to be isolated. In some cell types, it has recently been suggested that AEA, an uncharged hydrophobic molecule, passively diffuses through the plasma membrane in a process that is not protein-mediated.
Sherrye T, Glaser +2 more
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The Biodisposition and Metabolism of Anandamide in Mice
The Journal of Pharmacology and Experimental Therapeutics, 1997The endogenous cannabinoid anandamide (AN) has been reported to produce pharmacological effects similar to those of delta9-tetrahydrocannabinol but with a shorter duration of action. Also, AN is known to be metabolized to arachidonic acid. The purpose of this study was to examine the time course of distribution and metabolism of AN. Male mice were each
K A, Willoughby +3 more
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Biosynthetic Pathways of the Endocannabinoid Anandamide
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Yasuo, Okamoto +3 more
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Is GPR55 an anandamide receptor?
Vitamins and hormones, 2009Anandamide activates CB(1) cannabinoid receptors but also has effects, particularly in the vasculature, that cannot be explained by actions at either this or the other cloned cannabinoid receptor, the CB(2) receptor. These effects are probably mediated by a novel G protein-coupled receptor, but genome searching has not revealed a strong candidate ...
Andrew J, Brown, C, Robin Hiley
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