Results 211 to 220 of about 31,279 (264)
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Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
Anandamide (N -arachidonoyl-ethanolamine, AEA) was the first endogenous ligand of cannabinoid receptors to be discovered. Yet, since early studies, AEA appeared to exhibit also some effects that were not mediated by cannabinoid CB(1) or CB(2) receptors.
Di Marzo V +4 more
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Anandamide (N -arachidonoyl-ethanolamine, AEA) was the first endogenous ligand of cannabinoid receptors to be discovered. Yet, since early studies, AEA appeared to exhibit also some effects that were not mediated by cannabinoid CB(1) or CB(2) receptors.
Di Marzo V +4 more
openaire +6 more sources
Pharmacology & Therapeutics, 2004
N-Arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid CB1 and CB2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-THC), the active component of marijuana. As with any neurotransmitter, there must be tight control of anandamide receptor-mediated signaling
Matthew J, McFarland, Eric L, Barker
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N-Arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid CB1 and CB2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-THC), the active component of marijuana. As with any neurotransmitter, there must be tight control of anandamide receptor-mediated signaling
Matthew J, McFarland, Eric L, Barker
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Fundamental & Clinical Pharmacology, 2006
AbstractEndocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2‐arachidonoylglycerol.
K, Smita +2 more
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AbstractEndocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2‐arachidonoylglycerol.
K, Smita +2 more
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Cardiovascular pharmacology of anandamide
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002The fatty acid amide anandamide produces hypotension and a decrease in systemic vascular resistance in vivo. A drop in blood pressure is also seen with synthetic cannabinoid (CB) receptor agonists. The hypotensive responses to anandamide and synthetic cannabinoids are absent in CB1 receptor gene knockout mice. In isolated arteries and perfused vascular
Edward D, Högestätt, P M, Zygmunt
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Oxidative metabolism of anandamide
Prostaglandins & Other Lipid Mediators, 2000In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES.
S H, Burstein +3 more
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Biphasic Effects of Anandamide
Pharmacology Biochemistry and Behavior, 1998Effects of the endogenous cannabimimetic anandamide were assessed over a wide dose range in a series of physiological and behavioral assays. These included the tetrad of tests in mice commonly used to assess cannabinoid-induced effects (motor activity, ring catalepsy, hypothermia, and analgesia tests), as well as a model for agonistic behavior on ...
E, Sulcova, R, Mechoulam, E, Fride
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Trends in Pharmacological Sciences, 2001
Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial.
Di Marzo V, Bisogno T, De Petrocellis L
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Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial.
Di Marzo V, Bisogno T, De Petrocellis L
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Anandamide transport: A critical review
Life Sciences, 2005Anandamide (AEA) uptake has been described over the last decade to occur by facilitated diffusion, but a protein has yet to be isolated. In some cell types, it has recently been suggested that AEA, an uncharged hydrophobic molecule, passively diffuses through the plasma membrane in a process that is not protein-mediated.
Sherrye T, Glaser +2 more
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Anandamide vehicles: a comparative study
European Journal of Pharmacology, 2004Among the studies that investigate the vasorelaxation induced by anandamide, one of the most frequent differences is the use of distinct solvents that could modify vascular function and explain the controversial results described. The aims of this study were: to evaluate the influence of different cannabinoid vehicles in vascular function of rat aorta,
Visitación, López-Miranda +4 more
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Brain Research, 1998
Anandamide, an endogenous cannabinoid signaling molecule, in a concentration dependent manner, initiates the release of nitric oxide (NO) from leech and mussel ganglia. SR 141716A, a cannabinoid antagonist, blocks the anandamide stimulated release of NO from these tissues.
G B, Stefano +3 more
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Anandamide, an endogenous cannabinoid signaling molecule, in a concentration dependent manner, initiates the release of nitric oxide (NO) from leech and mussel ganglia. SR 141716A, a cannabinoid antagonist, blocks the anandamide stimulated release of NO from these tissues.
G B, Stefano +3 more
openaire +2 more sources