Results 221 to 230 of about 31,279 (264)

Enzymes for anandamide biosynthesis and metabolism

Journal of Lipid Mediators and Cell Signalling, 1996
Anandamide is an endogenous ligand for cannabinoid receptors. We tried to isolate and purify "anandamide amidohydrolase' which hydrolyzes anandamide to arachidonic acid and ethanolamine. The enzyme activity was found in the microsomal fraction of porcine brain homogenate.
N, Ueda, Y, Kurahashi, K, Yamamoto, S, Yamamoto, T, Tokunaga   +4 more
openaire   +2 more sources

Anandamide uptake explained?

Trends in Pharmacological Sciences, 2012
The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from the extracellular space by a process of cellular uptake followed by metabolism. Although the enzymes responsible for endocannabinoid metabolism have been well characterised, the processes involved in uptake have been the subject of much controversy.
openaire   +2 more sources

The rise and fall of anandamide: processes that control synthesis, degradation, and storage

Molecular and Cellular Biochemistry, 2021
R. Biringer
semanticscholar   +1 more source

Anandamide amidohydrolase (fatty acid amide hydrolase)

Prostaglandins & Other Lipid Mediators, 2000
Anandamide (N-arachidonoylethanolamine) loses its cannabimimetic activity when it is hydrolyzed to arachidonic acid and ethanolamine by the catalysis of an enzyme referred to as anandamide amidohydrolase or fatty acid amide hydrolase. Cravatt's group and our group cloned cDNA of the enzyme from rat, human, mouse and pig, and the primary structures ...
N, Ueda, S, Yamamoto
openaire   +2 more sources

Anandamide inhibits breast tumor-induced angiogenesis

Translational medicine @ UniSa, 2014
Breast cancer is one of the most frequently diagnosed malignancies and a leading cause of cancer death in women. Great advances in the treatment of primary tumors have led to a significant increment in the overall survival rates, however recurrence and ...
Paola Picardi, E. Ciaglia, M. Proto, S. Pisanti   +3 more
semanticscholar   +1 more source

Anandamide-loaded nanoparticles: Preparation and characterization

Journal of Microencapsulation, 2011
Preparation and characterization of anandamide (N-arachidonoyl-ethanolamine, AEA) loaded polycaprolactone nanoparticles (PCL NP) as a research tool to clarify the presence of an AEA transporter in cell membranes and to avoid AEA plastic adsorption and instability.High performance liquid chromatography and light scattering were used to determine ...
M R, Aberturas, D, Hernán Pérez de la Ossa, M E, Gil, A, Ligresti, L, Ligresti, L, De Petrocellis, A I, Torres, V, Di Marzo, J, Molpeceres   +8 more
openaire   +5 more sources

Solid-Phase Synthesis of Anandamide Analogues

Organic Letters, 2004
The endocannabinoids are amides and esters of arachidonic acid that can mimic the pharmacological properties of Delta(9)-tetrahydrocannabinol (Delta(9)-THC). Anandamide, the most prominent of the endocannabinoids, has been implicated in both metabolic/physiological roles of the central nervous system, making it an attractive medicinal target.
Longwu, Qi, Michael M, Meijler, Sang-Hyeup, Lee, Chengzao, Sun, Kim D, Janda   +4 more
openaire   +2 more sources

Toxicological assessment of anandamide

Archives of Clinical Toxicology
Anandamide (AEA), an endogenous cannabinoid, has been widely studied for its physiological roles and potential therapeutic applications. However, concerns remain regarding its safety profile, particularly at higher doses. Therefore, this study aimed to investigate the acute, subchronic and genetic toxicological effects of AEA.
Gloria Yi, George Gao, Wayne Yi, Long Jiang   +3 more
openaire   +1 more source

Anandamide receptor signal transduction.

Vitamins and hormones, 2009
In the 15 years since its discovery anandamide has been implicated in many physiological processes. The signaling pathways mediating many of these processes are now coming to light, particularly in the CNS. The complexity of the cannabinoid system and the identification of many potential other receptors for anandamide have made conclusive evidence of ...
Catherine E, Goodfellow, Michelle, Glass
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Enzymatic formation of anandamide.

Vitamins and hormones, 2009
In animal tissues anandamide and other bioactive N-acylethanolamines are principally produced from glycerophospholipids through the transacylation-phosphodiesterase pathway consisting of two enzymatic reactions. The first reaction is the generation of N-acylphosphatidylethanolamine (NAPE) by transferring an acyl group esterified at sn-1 position of ...
Yasuo, Okamoto, Kazuhito, Tsuboi, Natsuo, Ueda   +2 more
openaire   +1 more source