Results 11 to 20 of about 167,277 (315)
Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk
eLife, 2019 According to the prevailing ‘clock’ model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However,
Olga Afonso +9 more
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Molecular Biology of the Cell, 2019 Spindle microtubules, whose dynamics vary over time and at different locations, cooperatively drive chromosome segregation. Measurements of microtubule dynamics and spindle ultrastructure can provide insight into the behaviors of microtubules, helping ...
Che-Hang Yu +8 more
semanticscholar +4 more sources
The anaphase-promoting complex: proteolysis in mitosis and beyond. [PDF]
Molecular Cell, 2002 Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and ...
J. Peters
semanticscholar +4 more sources
Anaphase A: Disassembling Microtubules Move Chromosomes toward Spindle Poles
Biology, 2017 The separation of sister chromatids during anaphase is the culmination of mitosis and one of the most strikingly beautiful examples of cellular movement.
Charles L. Asbury
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A Wee1 checkpoint inhibits anaphase onset [PDF]
Journal of Cell Biology, 2013 The budding yeast Wee1 kinase Swe1 restrains the metaphase-to-anaphase transition by preventing the Cdk1-dependent phosphorylation and activation of APCCdc20.
Noel Lianga +7 more
semanticscholar +4 more sources
Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase. [PDF]
PLoS ONE, 2016 Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer.
Judit Pampalona +6 more
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Nature Communications, 2018 Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase.
Zhe Wei +3 more
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Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. [PDF]
Genes & Development, 1996 Anaphase initiation has been postulated to be controlled through the ubiquitin-dependent proteolysis of an unknown inhibitor. This process involves the anaphase promoting complex (APC), a specific ubiquitin ligase that has been shown to be involved in ...
O. Cohen-Fix +3 more
semanticscholar +4 more sources
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast [PDF]
Cell, 2000 Frank Uhlmann +4 more
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Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase. [PDF]
The Journal of cell biology, 1994 A novel anaphase block phenotype was found in fission yeast temperature-sensitive cut9 mutants. Cells enter mitosis with chromosome condensation and short spindle formation, then block anaphase, but continue to progress into postanaphase events such as degradation of the spindle, reformation of the postanaphase cytoplasmic microtubule arrays, septation,
Itaru Samejima, Mitsuhiro Yanagida
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