Results 11 to 20 of about 170,053 (305)

Anaphase A: Disassembling Microtubules Move Chromosomes toward Spindle Poles

Biology, 2017
The separation of sister chromatids during anaphase is the culmination of mitosis and one of the most strikingly beautiful examples of cellular movement.
Charles L. Asbury
doaj   +2 more sources

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase. [PDF]

PLoS ONE, 2016
Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer.
Judit Pampalona, Emanuele Roscioli, William T Silkworth, Brent Bowden, Anna Genescà, Laura Tusell, Daniela Cimini   +6 more
doaj   +2 more sources

Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes

Nature Communications, 2018
Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase.
Zhe Wei, Jessica Greaney, Chenxi Zhou, Hayden A. Homer   +3 more
doaj   +2 more sources

The anaphase-promoting complex: proteolysis in mitosis and beyond. [PDF]

Molecular Cell, 2002
J. Peters
semanticscholar   +2 more sources

PP1 promotes cyclin B destruction and the metaphase–anaphase transition by dephosphorylating CDC20

bioRxiv, 2020
Ubiquitin-dependent proteolysis of cyclin B and securin initiates sister chromatid segregation and anaphase. The anaphase promoting complex/cyclosome (APC/C) and its co-activator CDC20 form the main ubiquitin E3 ligase for these proteins.
James M. Bancroft, James Holder, Zoë Geraghty, Tatiana Alfonso-Pérez, Daniel J. Murphy, F. Barr, U. Gruneberg   +6 more
semanticscholar   +1 more source

Structural plasticity of the living kinetochore [PDF]

, 2017
The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of ...
Akiyoshi, Al-Bassam, Aravamudhan, Aravamudhan, Asbury, Biggins, Biggins, Boris Rubinstein, Brian D. Slaughter, Chan, Cheeseman, Culotti, Daniel, De Wulf, Desai, Duffy, Field, Foley, Gandhi, Gao, Gardner, Gestaut, Grishchuk, Guimaraes, Hartwell, He, Hedges, Hill, Hornung, Hornung, Jaspersen, Jay R. Unruh, Jeffrey J. Lange, Jennifer L. Gerton, Jin, Jin, Joglekar, Joglekar, Joglekar, Joglekar, Karthik Dhatchinamoorthy, Kim, Kosco, Lampert, Liu, Longtine, Mallavarapu, Malvezzi, Manjunatha Shivaraju, Mayer, McAinsh, McIntosh, McKinney, Meng, Mieck, Miller, Miranda, Ng, Obuse, Pavelka, Pearson, Pfau, Podolski, Powers, Ramey, Sarangapani, Schleiffer, Schmidt, Severin, Shivaraju, Smith, Stephens, Su, Suzuki, Tanaka, Tien, Tytell, Umbreit, Usui, van Breugel, van Hooff, Visintin, Walczak, Wang, Welburn, Westermann, Westermann, Winey, Wisniewski, Wolyniak, Yuen   +90 more
core   +1 more source

Rif1 Regulates the Fate of DNA Entanglements during Mitosis

Cell Reports, 2016
Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromosomes to segregate with high fidelity. Loss of Taz1 (fission yeast ortholog of human TRF1/TRF2) leads to stalled telomeric replication forks that trigger ...
Sophie Zaaijer, Nadeem Shaikh, Rishi Kumar Nageshan, Julia Promisel Cooper   +3 more
doaj   +1 more source

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]

, 2014
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen, Makrantoni, Vasso, Morrice, Nicholas A., Rachidi, Najma, Robinson, David A., Stark, Michael J. R.   +5 more
core   +4 more sources

Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase

Journal of Cell Biology, 2019
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood.
Cindy L. Fonseca, Heidi L. H. Malaby, Leslie A. Sepaniac, Whitney Martin, Candice Byers, A. Czechanski, Dana Messinger, Mary E Tang, R. Ohi, L. Reinholdt, Jason K. Stumpff   +10 more
semanticscholar   +1 more source

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Journal of Cell Biology, 2003
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase inhibitor.
Claire Ditchfield, V. L. Johnson, Anthony Tighe, Rebecca Ellston, Carolyn Haworth, Trevor Johnson, A. Mortlock, N. Keen, Stephen S. Taylor   +8 more
semanticscholar   +1 more source