Polo-like kinase controls vertebrate spindle elongation and cytokinesis. [PDF]
PLoS ONE, 2007 During cell division, chromosome segregation must be coordinated with cell cleavage so that cytokinesis occurs after chromosomes have been safely distributed to each spindle pole.
Ian M Brennan +3 more
doaj +1 more source
How to halve ploidy : lessons from budding yeast meiosis [PDF]
, 2012 Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash +2 more
core +1 more source
Cell Reports, 2017 The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC).
John C. Meadows +7 more
doaj +1 more source
Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]
, 2014 The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core +2 more sources
Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
Open Biology, 2017 The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators.
C. Alfieri, Suyang Zhang, D. Barford
semanticscholar +1 more source
APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa +7 more
doaj +1 more source
Immunocytochemical localization of chromatin regions UV-microirradiated in S phase or anaphase : Evidence for a territorial organization of chromosomes during cell cycle of cultured Chinese hamster cells [PDF]
, 1983 Chinese hamster cells (M3-1 line) in S phase were laser-UV-microirradiated (λ, 257 nm) at a small site of the nucleus. Cells were fixed either immediately thereafter or in subsequent stages of the cell cycle, including prophase and metaphase.
Avivi +33 more
core +1 more source
Force-generating mechanisms of anaphase in human cells
Journal of Cell Science, 2019 What forces drive chromosome segregation remains one of the most challenging questions in cell division. Even though the duration of anaphase is short, it is of utmost importance for genome fidelity that no mistakes are made.
Kruno Vukušić, Renata Buđa, I. Tolic
semanticscholar +1 more source
Proceedings of the National Academy of Sciences, 1996 Despite their varied appearances, all mitotic spindles have a similar architecture: they are organized as two half spindles, and the microtubules in each half spindle are of the same polarity, with many of the plus ends of the microtubules that grow out from the poles interacting with chromosomes or the microtubules of the other half spindle.
W Z, Cande, H J, Wein
openaire +2 more sources
Cohesin is dispensable for centromere cohesion in human cells. [PDF]
PLoS ONE, 2007 Proper regulation of the cohesion at the centromeres of human chromosomes is essential for accurate genome transmission. Exactly how cohesion is maintained and is then dissolved in anaphase is not understood.We have investigated the role of the cohesin ...
Laura A Díaz-Martínez +2 more
doaj +1 more source