Results 21 to 30 of about 52,438 (267)
eLife, 2022 Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role determining the ...
Jonay Garcia-Luis +4 more
doaj +1 more source
Rif1 Regulates the Fate of DNA Entanglements during Mitosis
Cell Reports, 2016 Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromosomes to segregate with high fidelity. Loss of Taz1 (fission yeast ortholog of human TRF1/TRF2) leads to stalled telomeric replication forks that trigger ...
Sophie Zaaijer +3 more
doaj +1 more source
Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2021 The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault +8 more
doaj +1 more source
Polo-like kinase controls vertebrate spindle elongation and cytokinesis. [PDF]
PLoS ONE, 2007 During cell division, chromosome segregation must be coordinated with cell cleavage so that cytokinesis occurs after chromosomes have been safely distributed to each spindle pole.
Ian M Brennan +3 more
doaj +1 more source
Journal of Cell Biology, 2019 Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood.
Cindy L Fonseca +10 more
semanticscholar +1 more source
Anaphase B Precedes Anaphase A in the Mouse Egg [PDF]
Current Biology, 2012 Segregation of chromosomes at the time of cell division is achieved by the microtubules and associated molecules of the spindle. Chromosomes attach to kinetochore microtubules (kMTs), which extend from the spindle pole region to kinetochores assembled upon centromeric DNA.
openaire +4 more sources
Force-generating mechanisms of anaphase in human cells
Journal of Cell Science, 2019 What forces drive chromosome segregation remains one of the most challenging questions in cell division. Even though the duration of anaphase is short, it is of utmost importance for genome fidelity that no mistakes are made.
Kruno Vukušić, Renata Buđa, I. Tolic
semanticscholar +1 more source
Testing of mitosis and meiosis in female and male gametes
Андрология и генитальная хирургия, 2017 Method of quantitative evaluation of the immature germ cells, their pathology in mitosis and meiosis (in semen, embryo and fetal ovaries, of gonad biopsies or fragments of sectioned material) is informative method and should be introduced into the ...
L. F. Kurilo, S. Sh. Khayat
doaj +1 more source
Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
Open Biology, 2017 The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators.
C. Alfieri, Suyang Zhang, D. Barford
semanticscholar +1 more source
Keeping Order in Anaphase [PDF]
Developmental Cell, 2015 The critical components of chromosome segregation machinery are well established, but how they orchestrate the relative order of events during mitosis remains unclear. Kamenz et al. (2015) now report in Molecular Cell quantitative data suggesting competing networks and adaptive thresholds in the control of mitotic exit by the anaphase-promoting complex.
openaire +4 more sources