Results 21 to 30 of about 64,230 (279)
Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]
, 2014 Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Amalie E. Dick +36 more
core +1 more source
Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk
eLife, 2019 According to the prevailing ‘clock’ model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the metaphase-anaphase transition, controlled by the spindle assembly checkpoint. However,
Olga Afonso +9 more
doaj +1 more source
Polo-like kinase controls vertebrate spindle elongation and cytokinesis. [PDF]
PLoS ONE, 2007 During cell division, chromosome segregation must be coordinated with cell cleavage so that cytokinesis occurs after chromosomes have been safely distributed to each spindle pole.
Ian M Brennan +3 more
doaj +1 more source
A novel chromosome segregation mechanism during female meiosis. [PDF]
, 2016 In a wide range of eukaryotes, chromosome segregation occurs through anaphase A, in which chromosomes move toward stationary spindle poles, anaphase B, in which chromosomes move at the same velocity as outwardly moving spindle poles, or both. In contrast,
Cortes, Daniel B +4 more
core +1 more source
Anaphase B Precedes Anaphase A in the Mouse Egg [PDF]
Current Biology, 2012 Segregation of chromosomes at the time of cell division is achieved by the microtubules and associated molecules of the spindle. Chromosomes attach to kinetochore microtubules (kMTs), which extend from the spindle pole region to kinetochores assembled upon centromeric DNA.
openaire +4 more sources
Cystathionine β‐synthase is required for oocyte quality by ensuring proper meiotic spindle assembly
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 CBS is required for oocyte quality by ensuring proper spindle assembly. During oocyte meiotic maturation, CBS ensures spindle assembly by participating in the acetylation of α‐tubulin to stabilize microtubules. Kinetochores remain attached by spindle microtubules. SAC is removed from the kinetochores and then the chromosomes can be separated correctly.
Yan Cao +9 more
wiley +1 more source
The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos. [PDF]
, 2015 Chromosome segregation during anaphase depends on chromosome-to-pole motility and pole-to-pole separation. We propose that in Drosophila embryos, the latter process (anaphase B) depends on a persistent kinesin-5-generated interpolar (ip) microtubule (MT)
Brust-Mascher, Ingrid +2 more
core +1 more source
SETDB1 regulates microtubule dynamics
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 SETDB1 association with microtubules inhibits microtubule polymerization and enhances their instability. SETDB1 may affect the microtubules by interacting with HDAC6 to enhance HDAC6 tubulin deacetylation activity. Abstract Objectives SETDB1 is a methyltransferase responsible for the methylation of histone H3‐lysine‐9, which is mainly related to ...
Rosari Hernandez‐Vicens +4 more
wiley +1 more source
Testing of mitosis and meiosis in female and male gametes
Андрология и генитальная хирургия, 2017 Method of quantitative evaluation of the immature germ cells, their pathology in mitosis and meiosis (in semen, embryo and fetal ovaries, of gonad biopsies or fragments of sectioned material) is informative method and should be introduced into the ...
L. F. Kurilo, S. Sh. Khayat
doaj +1 more source
Keeping Order in Anaphase [PDF]
Developmental Cell, 2015 The critical components of chromosome segregation machinery are well established, but how they orchestrate the relative order of events during mitosis remains unclear. Kamenz et al. (2015) now report in Molecular Cell quantitative data suggesting competing networks and adaptive thresholds in the control of mitotic exit by the anaphase-promoting complex.
openaire +4 more sources