Results 31 to 40 of about 52,438 (267)
APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the main cause of dementia in the elderly. The disease has a high impact on individuals and their families and represents a growing public health and socio-economic burden ...
Rebeca Lapresa +7 more
doaj +1 more source
Cell Reports, 2017 The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC).
John C. Meadows +7 more
doaj +1 more source
Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset. [PDF]
PLoS Genetics, 2018 Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically links sister chromatids ...
Noel Lianga +8 more
doaj +1 more source
Journal of Cell Biology, 2003 The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase inhibitor.
Claire Ditchfield +8 more
semanticscholar +1 more source
Anaphase Promoting Complex or Cyclosome? [PDF]
Cell Cycle, 2005 The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C.
Duncan J. Clarke +2 more
openaire +3 more sources
Male meiotic spindle features that efficiently segregate paired and lagging chromosomes
eLife, 2020 Chromosome segregation during male meiosis is tailored to rapidly generate multitudes of sperm. Little is known about mechanisms that efficiently partition chromosomes to produce sperm.
Gunar Fabig +9 more
doaj +1 more source
Cohesin is dispensable for centromere cohesion in human cells. [PDF]
PLoS ONE, 2007 Proper regulation of the cohesion at the centromeres of human chromosomes is essential for accurate genome transmission. Exactly how cohesion is maintained and is then dissolved in anaphase is not understood.We have investigated the role of the cohesin ...
Laura A Díaz-Martínez +2 more
doaj +1 more source
Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation
eLife, 2022 The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the ...
Alex F Thompson +7 more
doaj +1 more source
SUMO targets the APC/C to regulate transition from metaphase to anaphase
Nature Communications, 2018 Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects
K. Eifler +7 more
semanticscholar +1 more source
Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p [PDF]
Proceedings of the National Academy of Sciences, 2001 Kip1p of Saccharomyces cerevisiae is a bipolar kinesin in the conserved bimC kinesin subfamily that mediates mitotic spindle–pole separation. Here, we show that Kip1p is regulated immediately after anaphase initiation by its rapid degradation.
Donna M. Gordon, David M. Roof
openaire +2 more sources