Results 31 to 40 of about 66,778 (245)
A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition
Cell Reports, 2016 To achieve chromosome segregation during mitosis, sister chromatids must undergo a dramatic change in their behavior to switch from balanced oscillations at the metaphase plate to directed poleward motion during anaphase.
Kuan-Chung Su +5 more
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Cell Reports, 2015 Condensin is a conserved chromosomal complex necessary to promote mitotic chromosome condensation and sister chromatid resolution during anaphase. Here, we report that yeast condensin binds to replicated centromere regions.
Joanne Leonard +6 more
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Bub1-mediated adaptation of the spindle checkpoint. [PDF]
PLoS Genetics, 2011 During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules.
Greicy H Goto +4 more
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Cell, 2000 Although all the pieces of the puzzle may seem to be in place, there are still several key processes that have been widely posited but remain experimentally unverified. What attracts Mad2 to the kinetochore and what causes its release? Is it Mad1, as has been hypothesized from its apparent loss (along with Mad2) from the kinetochore after microtubule ...
Don W. Cleveland, Jagesh V. Shah
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Early onset of APC/C activity renders SAC inefficient in mouse embryos
Frontiers in Cell and Developmental BiologyControl mechanisms of spindle assembly and chromosome segregation are vital for preventing aneuploidy during cell division. The mammalian germ cells and embryos are prone to chromosome segregation errors, and the resulting aneuploidy is a major cause of ...
Adela Horakova +9 more
doaj +1 more source
PLoS ONE, 2012 Centromeres are specialized chromosome domains that control chromosome segregation during mitosis, but little is known about the mechanisms underlying the maintenance of their integrity.
Sébastien Rouzeau +8 more
doaj +1 more source
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I
Nature Communications, 2022 Spindle assembly checkpoint controls anaphase onset and guarantees appropriate chromosome segregation. Here, the authors report that dynamin-related protein 1 is recruited to kinetochores by CENP-F to regulate metaphase-to-anaphase transition by ...
Cheng-Jie Zhou +8 more
doaj +1 more source
Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast. [PDF]
PLoS Genetics, 2015 Substrate dephosphorylation by the cyclin-dependent kinase (Cdk)-opposing phosphatase, Cdc14, is vital for many events during budding yeast mitotic exit.
Molly Godfrey +2 more
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A Wee1 checkpoint inhibits anaphase onset [PDF]
Journal of Cell Biology, 2013 Cdk1 drives both mitotic entry and the metaphase-to-anaphase transition. Past work has shown that Wee1 inhibition of Cdk1 blocks mitotic entry. Here we show that the budding yeast Wee1 kinase, Swe1, also restrains the metaphase-to-anaphase transition by preventing Cdk1 phosphorylation and activation of the mitotic form of the anaphase-promoting complex/
Elizabeth C. Williams +7 more
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Spatial control of the anaphase-telophase transition [PDF]
Cell Cycle, 2014 The ultimate goal of mitosis is to physically separate the entire set of duplicated chromosomes in order to propagate the genetic information during cell division. The perpetuation of a faithful maintenance of the genome integrity can only be guaranteed by the existence of multiple cell cycle checkpoints.1 In particular, mitosis is a highly regulated ...
Olga Afonso, Irina Matos, Helder Maiato
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