Results 41 to 50 of about 52,438 (267)
Detection of Ultrafine Anaphase Bridges [PDF]
, 2017 Ultrafine anaphase bridges (UFBs) are thin DNA threads linking the separating sister chromatids in the anaphase of mitosis. UFBs are thought to form when topological DNA entanglements between two chromatids are not resolved prior to anaphase onset.
Bizard, Anna H +2 more
openaire +4 more sources
Anaphase specific auto‐cleavage of separase [PDF]
FEBS Letters, 2002 Sister‐chromatid separation is triggered by a specific proteolytic cleavage of chromosomal cohesins catalyzed by the endopeptidase separase. Prior to anaphase, separase is inhibited independently by affinity binding to securin and by specific inhibitory phosphorylation.
Zou, H. +4 more
openaire +4 more sources
Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
doaj +1 more source
A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition
Cell Reports, 2016 To achieve chromosome segregation during mitosis, sister chromatids must undergo a dramatic change in their behavior to switch from balanced oscillations at the metaphase plate to directed poleward motion during anaphase.
Kuan-Chung Su +5 more
doaj +1 more source
Cell Reports, 2015 Condensin is a conserved chromosomal complex necessary to promote mitotic chromosome condensation and sister chromatid resolution during anaphase. Here, we report that yeast condensin binds to replicated centromere regions.
Joanne Leonard +6 more
doaj +1 more source
Cell, 2000 Although all the pieces of the puzzle may seem to be in place, there are still several key processes that have been widely posited but remain experimentally unverified. What attracts Mad2 to the kinetochore and what causes its release? Is it Mad1, as has been hypothesized from its apparent loss (along with Mad2) from the kinetochore after microtubule ...
Don W. Cleveland, Jagesh V. Shah
openaire +3 more sources
PLoS ONE, 2012 Centromeres are specialized chromosome domains that control chromosome segregation during mitosis, but little is known about the mechanisms underlying the maintenance of their integrity.
Sébastien Rouzeau +8 more
doaj +1 more source
Bub1-mediated adaptation of the spindle checkpoint. [PDF]
PLoS Genetics, 2011 During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules.
Greicy H Goto +4 more
doaj +1 more source
Early onset of APC/C activity renders SAC inefficient in mouse embryos
Frontiers in Cell and Developmental BiologyControl mechanisms of spindle assembly and chromosome segregation are vital for preventing aneuploidy during cell division. The mammalian germ cells and embryos are prone to chromosome segregation errors, and the resulting aneuploidy is a major cause of ...
Adela Horakova +9 more
doaj +1 more source
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I
Nature Communications, 2022 Spindle assembly checkpoint controls anaphase onset and guarantees appropriate chromosome segregation. Here, the authors report that dynamin-related protein 1 is recruited to kinetochores by CENP-F to regulate metaphase-to-anaphase transition by ...
Cheng-Jie Zhou +8 more
doaj +1 more source